Nature Communications
Articles in this Issue
PITX2 dosage-dependent changes in pacemaker cell state underlie sinus node dysfunction and atrial arrhythmias
Abstract Physiologically relevant increases in transcription factor dosage and their role in development and disease remain largely unexplored. Genomic deletions...
Decline in HIV prevalence among female sex workers in Zimbabwe between 2013 and 2023
Abstract HIV epidemic trends among female sex workers in sub-Saharan Africa are rarely known. We analysed HIV prevalence trends among 10,562 female sex workers aged 18–39 years, recr...
Single cell mapping identifies a distinct platelet-phenotype in psoriatic type III inflammation
Abstract The understanding of platelet biology is expanding beyond their well-established role in thrombosis and hemostasis to encompass their functions in infla...
Sublinear transport in Kagome metals from the interplay of Dirac cones and Van Hove singularities
Abstract Recent experiments have revealed that many kagome metals exhibit sublinear temperature dependence in resistivity up to room temperature. Here, we develop a minimal semiclass...
The Human T-cell Leukemia Virus capsid protein is a potential drug target
Abstract Human T-cell Leukaemia Virus type 1 (HTLV-1) is an untreatable retrovirus that causes lethal malignancies and degenerative inflammatory conditions. Effective treatments have...
Defective vascular smooth muscle cell tafazzin impairs mitochondrial function and promotes atherosclerosis in preclinical models
Abstract Atherosclerotic lesions show significant mitochondrial dysfunction but the underlying mechanisms and consequences remain unknown. Cardiolipin is a phospholipid found exclusi...
Spatial proximity dictates bacterial competition and expansion in microbial communities
A bypass gateway from cholesterol to sex steroid biosynthesis circumnavigates CYP17A1
Hierarchical crack-resistant, tissue-mimetic hydrogels enabled by progressive nanocrystallization of anisotropic polymer networks
Abstract Addressing the persistent challenge of reconciling extreme mechanical robustness with tissue-mimetic functionality in hydrogels, we present a phase-tran...
Design rules for anion-doped catalysts revealed by p-p-s orbital coupling in Li-S chemistry
Considerations and perspectives on phage therapy from the transatlantic taskforce on antimicrobial resistance
Abstract Amid rising antimicrobial resistance and limited antibiotic innovation, bacteriophages are gaining attention as potential therapeutics across human health, animal, and food...
Reversibility, regulation, and the community of development: the legacy of Sir John B. Gurdon
Two Nations, One Front: Indonesia and Papua New Guinea forge a One-Island approach to fight persistent malaria on New Guinea
Health data science revolution in Africa: potential for addressing the myriad health challenges
Autoantibody landscape and functional role of anti-C-C motif chemokine receptor 8 autoantibodies in systemic sclerosis: post-hoc analysis of a B-cell depletion trial
Spatiotemporal profiling of modification-specific proteome secretion uncovers an itaconation-activated tyrosine kinase
Abstract Macrophages secrete diverse signaling proteins critical for intercellular communication and immune responses, processes tightly regulated by post-translational modifications...
Hierarchical self-assembly of simple hard polyhedra into complex mesophases
Abstract Nature offers many intriguing examples of hierarchically self-assembled mesophases, such as lamellar, gyroid, hexagonal, and cholesteric phases. These structures are typical...
Inducible chromosomal rearrangement reveals nonlinear polygenic dosage effects in driving aneuploid yeast traits
Cytochrome c oxidase dependent respiration is essential for T cell activation, proliferation and memory formation
Abstract T cell activation requires extensive metabolic reprogramming, but the specific requirement for mitochondrial respiration (MR) remains unresolved. While most studies have foc...
Spontaneous droplet transport on shape-evolving microfiber rails
Abstract Directional droplet motion on solid surfaces, governed by Gibbs’ theory of minimizing surface free energy, traditionally relies on static surface gradients. However, such ap...