Nature Communications
Articles in this Issue
Hydrogen-bonded organic framework@conductive metal-organic framework heterostructures for ampere-level hydrogen peroxide production
Abstract Electrochemical two-electron oxygen reduction reaction (2e – ORR) in neutral environments holds remarkable promi...
Mitochondria-targeted gene delivery using fluorinated lipid nanoparticles to alleviate Leber’s hereditary optic neuropathy
Pericytes orchestrate a tumor-restraining microenvironment in glioblastoma
Abstract Glioblastoma (GBM) is characterized by fast progression, infiltrative growth pattern, and a high relapse rate. A defining feature of GBM is the existenc...
Faecal metabolites as a readout of habitual diet capture dietary interactions with the gut microbiome
Abstract The interplay between diet and gut microbiome composition is complex. Faecal metabolites, the end products of human and microbial metabolism, provide insights into these int...
Bio-inspired cross-modal super-additive plasticity for seamless visual processing-in-sensory and -in-memory
Molecular insights into species-specific ACE2 recognition of coronavirus HKU5
Hydrotrope-enabled high concentration aqueous electrolytes for reversible and sustainable iron metal anodes
The Vap33 signaling axis precisely coordinates the timing of motoneuron dendritogenesis in neural map development
Discovery of an allosteric binding site for anthraquinones at the human P2X4 receptor
Abstract P2X receptors are trimeric ATP-gated ion channels. The P2X4 receptor subtype is a promising drug target for the treatment of inflammatory diseases, neuropathic pain, and can...
Indigenous infants in remote Australia retain an ancestral gut microbiome despite encroaching Westernization
Longitudinal proteomic profiling of cerebrospinal fluid in untreated multiple sclerosis defines evolving disease biology
Abstract Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system, but the molecular mechanisms underlying its course remain incompletely understood. W...
MetaboLM: a metabolomic language model for multi-disease early prediction and risk stratification
On-surface synthesis of tailored organic platforms for single metal atoms
Abstract Recent advances in nanomaterials have pushed the boundaries of nanoscale fabrication to the limit of single atoms, particularly in heterogeneous catalys...
Confirmation-dependent organic phosphor reveals amino acid nanoaggregates in ice with insight for prebiotic chemistry
Dynamic omnivory shapes the functional role of large carnivores under global change
Abstract Omnivory is increasingly recognized as a dynamic stabilizing force under environmental change. Despite its ubiquity across ecosystems, trophic levels and spatiotemporal scal...
Development of a p62 biodegrader for autophagy targeted degradation
Abstract Autophagy-based targeted degradation offers a powerful complement to proteasomal degradation leveraging the capacity and versatility of lysosomes to degrade complex cargo. H...
Demonstration of CMOS-compatible memristor-based electrochemical biosensor transducer with threshold-sensing functionality
Abstract Many electrochemical biosensors operate based on a threshold-sensing (TS) method, which indicates the presence of a disease when the concentration of a...
Lattice-hydrogen cycling mechanism enables pH-universal hydrogen evolution at ampere-level current densities
Abstract Controllable supply of hydrogen intermediate across a wide pH range is crucial for electroreduction reactions, but is hindered by pH-dependent hydrogen...
APIP regulates the priming of canonical NLRP3 and non-canonical Caspase-11/4 inflammasomes by binding to TRAF6
The E2F1-HMGCR axis promotes ferroptosis resistance in immune refractory tumor cells
Abstract During cancer immunoediting, cancer cells deregulate cell death executioner mechanisms to escape immunotherapy-induced antitumor immunity. Ferroptosis, a type of regulated n...
Molecular basis for multidrug efflux by an anaerobic-associated RND transporter
Abstract Bacteria can resist antibiotics and toxic substances within demanding ecological settings, such as low oxygen, extreme acid, and during nutrient starvat...
Mechanically-robust and humidity-tunable self-destructive polymers enabled by hydrogen-bond nanoconfinement
Effect of hydrogen migration on the electronic structure of phenol derivatives observed by single-molecule conductance
Laminar organization of pyramidal neuron cell types defines distinct CA1 hippocampal subregions
Characterization of Anopheles gambiae immune cells through genetic and functional immunophenotyping
Abstract Mosquito immune cells, or hemocytes, are integral components of the innate immune responses that define vector competence. To date, the characterization...