Nature Communications
Articles in this Issue
Healthy vaccinee effect in the evaluation of updated COVID-19 vaccines in elderly populations
Abstract Established determinants of health in the elderly help guide routines for indicated vaccine administration, while unmeasured frailty may limit vaccine a...
Cost competitiveness of alternative heavy-duty truck technologies under real-world utilisation profiles
Abstract Road freight transport is essential to modern economies, yet its decarbonization remains challenging. While previous studies often focused on average-du...
The Plasmodium heme detoxification protein functions in mitochondrial protein synthesis
Abstract Malaria blood-stage parasites digest ~80% of host cell hemoglobin within a degradative vacuole, releasing heme that is detoxified by sequestration into hemozoin crystals. Al...
Heat stress promotes pre-tRNA capping to modulate cap-dependent translation in Saccharomyces cerevisiae
Systematic profiling of growth interactions in human gut microbiome species
Abstract Microbial interactions shape the composition and stability of the human gut microbiome. Yet, few studies have systematically investigated species-specie...
Vitamin B12 alleviates spliceosomopathy via phospholipid remodeling
Abstract mRNA splicing represents a fundamental level of gene regulation that alters proteomic diversity and cellular state. Its dysfunction can profoundly rewir...
All-optical Mie void sensor for complex nanoplastic mixtures
Abstract The fragmentation and direct release of plastic debris have emerged as a pressing ecological concern. Once dispersed, these particles infiltrate food webs, accumulate within...
Melt burst events in a dominantly amagmatic lithosphere at Gakkel Ridge in the Arctic Ocean
Abstract Alternation of magmatic and amagmatic seafloor along the slow and ultraslow spreading ridges is common. Yet, temporal variation is obscured by sediments blanketing oceanic b...
Angstrom-fluidic chemical synapses for accurate cancer diagnosis
Push until it breaks: engineering is stronger when we know its limits
Explainable AI: learning from the learners
Leaf development regulates state transition capacity in trees
Abstract State transitions (ST) balance excitation energy between photosystem I and II. This process has been extensively studied in Arabidop...
Retraction Note: Proteogenomics of diffuse gliomas reveal molecular subtypes associated with specific therapeutic targets and immune-evasion mechanisms
Structure-based scaffold hopping reveals strategies to overcome oncogenic KIT and PDGFRA mutation-driven drug-resistance in GIST
Abstract Gastrointestinal stromal tumors (GIST) are the most common mesenchymal tumors of the gastrointestinal tract. Current tyrosine kinase inhibitors (TKIs) targeting oncogenic KI...
α-Synuclein blocks endoplasmic reticulum co-translational protein translocation early in Parkinson’s disease
Abstract The primary mechanism and subcellular localisation of α-synuclein toxicity in Parkinson’s disease pathogenesis remain unknown. We spatially and temporally resolved proteomic...
Spatially defined Rabi spectroscopy for uninterrupted optical clock interrogation
Abstract Optical lattice clocks achieve fractional frequency uncertainties of 10⁻¹⁸, yet stability is constrained by the dead time between cooling, preparation, interrogation, and de...
Retraction Note: Proteomic characterization identifies clinically relevant subgroups of soft tissue sarcoma
Cell size reduction distinctly scales spindle elongation and chromosome segregation in C. elegans
Abstract How embryos adapt their internal cellular machinery to reductions in cell size during development remains a fundamental question in cell biology. Here,...
Biomechanics-informed inertial tracking achieves the accuracy of marker-based kinematics
Extensive binding of poorly characterized human transcription factors to genomic dark matter
Abstract The functional impact of a large portion of the human genome known as “dark matter DNA”, which is composed mainly of repeat sequences, remains unknown....
Structural basis for the contribution of latent TGFβ binding protein to TGFβ latency and activation
Abstract Transforming growth factor-β (TGFβ) is a potent cytokine that controls all aspects of cellular behavior. TGFβ is secreted in complex with its prodomain and latent TGFβ-bindi...
Genome shuffling enables quantitative trait locus mapping in Bacillus subtilis
Abstract Genetic mapping is a powerful tool for eukaryotic genetics that has only been applied to bacteria in limited circumstances. Quantitative trait locus (QT...
Identification of methylation-sensitive human transcription factors using meSMiLE-seq
Abstract Transcription factors (TFs) are key players in eukaryotic gene regulation, but the DNA binding specificity of many TFs remains unknown. Here, we assay 284 mostly uncharacter...
Farming practices exert selection pressures on the resistome of natural populations of house mice
Abstract The factors maintaining antimicrobial resistance genes (ARGs) in non-domesticated animal microbiomes remain unclear for species inhabiting human-dominat...
Structure of human cytoplasmic Pol II complex explains global transcription repression by GDOWN1
Abstract RNA polymerase II (Pol II) is a 12-subunit enzyme crucial for gene transcription in the nucleus. However, its assembly in the cytoplasm, nuclear import, and nuclear function...