Identification and characterization of binders to a cryptic and functional pocket in KRAS

Kim S. Beyer; Jessica Klein; Stéphanie Katz; Patrick Welker; Mylene Lanter; Daniel Guthy; Kerstin Pollehn; Aurélie Gluck-Gadé; Melusine Bleu; Jessica Desogus; Marc Hattenberger; Damiano Borrello; Wassim Abdul Rahman; Florence Zink; Nils Ostermann; Wolfgang Jahnke; Christoph E. Dumelin; Lukas Leder; Oliver Esser; Lionel Muller; Andreas Marzinzik; Regis Cébé; Kathrin Müller; Giorgio G. Galli; Luca Tordella; Simona Cotesta; Saskia M. Brachmann; Sauveur-Michel Maira

doi:10.1038/s41467-025-65844-3

Identification and characterization of binders to a cryptic and functional pocket in KRAS

K Kim S. Beyer J Jessica Klein S Stéphanie Katz P Patrick Welker M Mylene Lanter D Daniel Guthy K Kerstin Pollehn A Aurélie Gluck-Gadé M Melusine Bleu J Jessica Desogus M Marc Hattenberger D Damiano Borrello W Wassim Abdul Rahman F Florence Zink N Nils Ostermann (University of Göttingen, Institute of Inorganic Chemistry, Tammannstraße 4, D-37077 Göttingen, Germany) W Wolfgang Jahnke C Christoph E. Dumelin L Lukas Leder O Oliver Esser L Lionel Muller A Andreas Marzinzik R Regis Cébé K Kathrin Müller G Giorgio G. Galli L Luca Tordella S Simona Cotesta S Saskia M. Brachmann S Sauveur-Michel Maira

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published December 02, 2025

DOI 10.1038/s41467-025-65844-3

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (28)

K

Kim S. Beyer

J

Jessica Klein

S

Stéphanie Katz

P

Patrick Welker

M

Mylene Lanter

D

Daniel Guthy

K

Kerstin Pollehn

A

Aurélie Gluck-Gadé

M

Melusine Bleu

J

Jessica Desogus

M

Marc Hattenberger

D

Damiano Borrello

W

Wassim Abdul Rahman

F

Florence Zink

N

Nils Ostermann

University of Göttingen, Institute of Inorganic Chemistry, Tammannstraße 4, D-37077 Göttingen, Germany

W

Wolfgang Jahnke

C

Christoph E. Dumelin

L

Lukas Leder

O

Oliver Esser

L

Lionel Muller

A

Andreas Marzinzik

R

Regis Cébé

K

Kathrin Müller

G

Giorgio G. Galli

L

Luca Tordella

S

Simona Cotesta

S

Saskia M. Brachmann

S

Sauveur-Michel Maira

Identification and characterization of binders to a cryptic and functional pocket in KRAS

Article Details

Journal Info

Authors (28)

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