Journal of Clinical Oncology
Articles in this Issue
Analysis and management experience summary of immune-related adverse events in 136 gynecologic malignancies patients.
e17500 Background: The use of ICIs can lead to the occurrence of immune-related adverse events (irAEs), which result from non-specific reactions generated...
Oral fixed-dose cyclophosphamide and capecitabine combination: A novel therapeutic approach in advanced head and neck cancer.
e18013 Background: The treatment landscape for HNSCC is fraught with challenges stemming from late diagnoses, limited treatment access, and reduced tolera...
Safety and efficacy of the anti-TROP2 antibody-drug conjugate (ADC) IBI130 in patients (pts) with advanced triple-negative breast cancer (TNBC) and other solid tumors: Results from the phase 1 study.
1102 Background: TROP2 is a promising therapeutic target in various solid tumors. IBI130 is composed of an anti-TROP2 antibody conjugated to the camptothe...
Overuse of diagnostic, therapeutic, and consultative services among hospitalized patients approaching the end of life.
e23093 Background: Patients with cancer approaching the end of life (EOL) often undergo multiple diagnostic and therapeutic interventions, many of which d...
Ten-year patterns of women participating in treatment clinical trials for cancer.
e13754 Background: Ensuring adequate participation of women in cancer research is a national priority. Sex contributes to differences in cancer risk, trea...
Development and validation of a webcam-based tool to assess tongue motility and its correlation with speech intelligibility and swallowing following tongue cancer surgery.
e18088 Background: Tongue carcinoma ranks among the most prevalent malignancies in the Nepalese population. The tumour and its treatment adversely affect...
ImmunoDriver-1: Driver alterations (dAlts) and their immunological implications in early and metastatic non-small cell lung cancer (NSCLC).
8060 Background: NSCLC treatments and clinical trials include targeted agents and immunotherapy (IO) across stages, yet dAlts and how they relate to the t...
Biomarker testing and patient demographic disparities among breast cancer patients across treatment settings.
e13123 Background: Biomarker testing is crucial for personalizing breast cancer (BC) treatment. However, equitable access to biomarker testing and its imp...
Elucidating contributions to burden of disease in CNS progression for EGFR+ NSCLC.
e20692 Background: Central nervous system (CNS) metastases occur in 25-30% of patients with epidermal growth factor receptor (EGFR)+ non-small cell lung c...
Clinical investigators’ (CIs) practice patterns for patients with hormone receptor-positive metastatic breast cancer (HR+ mBC) harboring PI3K/AKT/PTEN pathway abnormalities (PAPm).
e13091 Background: Therapeutic targeting of PIK3CA mutations in patients with HR+ mBC has been a clinical reality since the 2019 FDA approval of alpelisib...
Understanding place-based inequities in lung cancer care: Trends in geographic hotspots of late-stage diagnoses and rates of cancer-directed surgery after Medicaid expansion in Indiana.
e23050 Background: While Medicaid expansion has been associated with improved cancer outcomes, current research often relies on aspatial methods and singl...
Randomized trial of a supportive oncology care at home intervention for patients with cancer receiving curative treatment.
11003 Background: Patients with cancer receiving curative treatment often endure substantial symptoms and utilize significant healthcare resources. Sympto...
The application of a novel split-type robotic system, Carina Platform, for esophageal surgery.
e16145 Background: Robotic esophageal surgery is becoming increasing popular. Most of recent publications on esophageal surgery used the da Vinci system....
Hypersensitivity reactions to platinums: Systematic review of efficacy and safety of desensitization.
e23326 Background: Platinum compounds carry a significant risk of hypersensitivity reactions (HSR), and repeated exposures can lead to IgE-mediated sensit...
Adverse events of interest (AEIs) with zanubrutinib vs fixed-duration combination of venetoclax + obinutuzumab in treatment-naive (TN) chronic lymphocytic leukemia (CLL).
e19028 Background: The efficacy and safety of BTKi zanubrutinib (zanu) monotherapy has been evaluated in TN CLL/SLL in SEQUOIA (NCT03336333), while the co...
Next-generation sequencing complemented with mini patient-derived xenografts to guide individualized treatment for patients with aggressive-variant prostate cancer.
e17050 Background: In this prospective, open, single-center interventional study (ClinicalTrials.gov Identifier: NCT03786848), we aimed to measure the cli...
Frontline treatment strategies in peripheral T-cell lymphoma: A network meta-analysis of efficacy outcomes.
e19065 Background: Peripheral T-cell Lymphomas (PTCLs) are rare, aggressive lymphoid malignancies with poor outcomes. Comparative data on frontline regime...
Communication skills training (CST) in hematology/oncology fellowships: Results from a multi-institutional needs assessment survey.
e21032 Background: Effective communication is critical in hematology/oncology (HO) practice, yet formal training in is variable across fellowship programs...
Performance evaluation of an AI-powered system for clinical trial eligibility using mCODE data standards.
e13621 Background: Automated data capture in oncology can expedite clinical trial enrollment by relieving the burdens of manual chart abstraction and ensu...
Use and benefit of adjuvant chemotherapy in early- vs average-onset colorectal cancer.
3615 Background: Despite improved mortality rates in colorectal cancer (CRC), the incidence of early onset-colorectal cancer (EO-CRC) has been rising in t...
Next-generation sequencing in patients with liposarcoma and rhabdomyosarcoma.
e23527 Background: Identifying targetable oncogenic drivers and resistance mechanisms by Next-generation sequencing (NGS) is critical in most cancers, inc...
Evaluation of the safety and efficacy of sintilimab combined with chemotherapy as neoadjuvant therapy for locally advanced gastric/gastroesophageal junction adenocarcinoma: Short-term results of a multicenter phase II study.
e16117 Background: Perioperative chemotherapy combined with gastrectomy and lymphadenectomy is the standard treatment for resectable locally advanced gast...
Epidermal growth factor receptor (EGFR) inhibitor-induced dermal toxicity treated with topical application of a novel Staphylococcus epidermidis compound.
TPS12149 Background: Agents targeting the EGFR-mediated signaling pathway are used for the treatment of advanced lung, pancreatic, colorectal, and head an...
Real-world efficacy and safety of durvalumab combined with various chemotherapy regimens in advanced biliary tract cancer: Insights from a large single-center study.
e16221 Background: The TOPAZ-1 study established durvalumab plus chemotherapy as a new standard of care for advanced biliary tract cancer (BTC). We presen...
Predictive value of PIK3CA mutations for response to CDK4/6 inhibitors in hormone receptor-positive, HER2-negative metastatic breast cancer: A systematic review and meta-analysis.
e13025 Background: Hormone receptor-positive, human epidermal growth factor receptor 2-negative (HR+/HER2-) breast cancer is the most common subtype of br...