Journal of Clinical Oncology
Articles in this Issue
Serum MUC5AC as a dynamic biomarker for tumor response, prognosis, and risk stratification in resected pancreatic ductal adenocarcinoma.
e16364 Background: There is an unmet need for novel biomarkers to guide and personalize treatment strategies for early-stage pancreatic ductal adenocarcin...
Real-world evidence of toxicity profile with cellular immunotherapy from India: Cellular insights study.
e14533 Background: Real-world data on adverse events (AEs) following adoptive cellular immunotherapy in India is scarce. This study evaluates the toxicity...
Neoadjuvant cadonilimab (anti-PD-1/CTLA-4 bispecific antibody) plus chemotherapy in early or locally advanced triple-negative breast cancer: A single-arm phase II trial (CABIN study).
599 Background: Neoadjuvant chemotherapy for triple-negative breast cancer (TNBC) can improve surgical outcomes; however, many patients fail to achieve pa...
The impact of burnout on oncologists and hematologists: <i>Nunc agendum est</i> (now is the time to act).
9014 Background: Burnout among oncologists is a pressing global issue, with prevalence rates ranging from 25% to 70%. South Asia, in particular, has repor...
Patient-reported experience with an immunotherapy telehealth platform.
1654 Background: The Making Teleheath Delivery of Cancer Care at Home Effective and Safe for Immunotherapy (MATCHES-IO) intervention seeks to improve the...
Survival outcomes in radioactive iodine-refractory (RAIR) differentiated thyroid cancer (DTC) with BRAF mutation: A real-world study from the Spanish Taskforce for Neuroendocrine and Endocrine Tumors (GETNE) Thyroid Cancer registry.
e18159 Background: For BRAF V600E RAIR-DTC, the role of BRAF with or without MEK inhibitors (BRAFi; MEKi) has been studied, given the success of these the...
Safety and efficacy of venetoclax and ibrutinib in relapsed/refractory chronic lymphocytic leukemia: A systematic review and meta-analysis.
e19035 Background: Chronic lymphocytic leukemia (CLL) is considered to be the most common leukemia in adults and remains incurable but newer oral targeted...
Impact of liquid biopsy on health-related quality of life in cancer treatment: A systematic review.
e14538 Background: Liquid biopsy has emerged as a promising tool in cancer management, offering non-invasive methods for monitoring disease progression an...
Baseline hematological parameters and outcomes in patients with prostate cancer treated with Lu-177 PSMA radioligand therapy (RLT): A multicenter real-world analysis.
e17047 Background: Patients (Pts) with Prostate Cancer (PC) receiving RLT are at risk of developing cytopenias that can cause dose holds or early treatmen...
Efficacy and safety of dordaviprone (ONC201) in prospective clinical trials of adult and pediatric recurrent H3 K27M-mutant diffuse glioma patients.
10017 Background: Dordaviprone (ONC201), a first in class imipridone, has demonstrated safety and efficacy in an integrated analysis of patients with recu...
Integrative oncology interest in persons with a cancer diagnosis.
11100 Background: Integrative oncology (IO) is an evidence-informed field of cancer care that utilizes mind-body practices, natural products, and lifestyl...
Association between the presence of malignant ascites and survival outcomes of gastric cancer patients treated with nivolumab plus chemotherapy.
e16057 Background: Malignant ascites is associated with poor outcomes in advanced gastric cancer, but its prognostic value has not been confirmed in the c...
Women’s breast cancer mortality trends: The impact of lifestyle factors from the 2021 Global Burden of Disease (GBD) study.
10602 Background: Breast cancer (BC) remains a leading cause of death among women globally. Understanding the role of modifiable risk factors is critical...
Preoperative PD-1 inhibitor (tislelizumab) plus SOX for locally advanced gastric or gastro-oesophageal junction cancer: Results from a single-arm, phase II trial.
e16140 Background: Although perioperative chemotherapy is the standard treatment regimen for locally advanced gastric cancer, the pathological complete re...
Use of STAMP-seq to enable spatial transcriptomics through single-nucleus in situ tagging and exploration of relationship of dynamic plasma cell modules and immunotherapy response in non-small cell lung cancer.
e20040 Background: Immunotherapy has revolutionized cancer treatment, particularly in non-small cell lung cancer (NSCLC), yet a large fraction of patients...
Preoperative axillary US and MRI in early-stage breast cancer: Potential to prevent unnecessary axillary surgery.
577 Background: Recent studies, including the INSEMA and SOUND trials, have demonstrated that omitting sentinel lymph node (SLN) biopsy does not adversely...
Sacituzumab tirumotecan (sac-TMT) in combination with tagitanlimab (anti-PD-L1) in first-line (1L) advanced non-small-cell lung cancer (NSCLC): Non-squamous cohort from the phase II OptiTROP-Lung01 study.
8529 Background: Sac-TMT (MK-2870/SKB264) is a TROP2 ADC developed with a novel linker to conjugate a belotecan-derivative...
Outcomes of follicular lymphoma patients hospitalized with viral respiratory illnesses: A national population-based study.
e19066 Background: Follicular lymphoma (FL) is an indolent B cell disorder with improving OS with the evolution of new drug agents. Prior studies have sho...
Accrual of historically underrepresented patients with multiple myeloma using centralized screening in a multicenter study.
e13709 Background: Patient (pt) identification, which is resource-intensive and time-consuming, can impede accrual to oncology trials, particularly in com...
Evaluating multiplex immunofluorescence analysis of the tumor microenvironment for predicting immunotherapy efficacy in NSCLC compared to traditional biomarkers.
e20600 Background: Only a subset of patients (pts) with advanced non-small cell lung cancer (aNSCLC) benefits from treatment with immune checkpoint inhibi...
Combined preoperative segmental hepatic arteries embolization with hepatic artery resection in radical pancreatic resections for locally advanced pancreatic cancer.
e16386 Background: Locally advanced pancreatic ductal adenocarcinoma (LA-PDAC) combined with hepatic arteries invasion is usually considered unresectable....
A randomized phase III trial investigating platinum and taxane chemotherapy in metastatic castration resistant prostate cancer (mCRPC) patients with alterations in DNA damage response (DDR) genes (OPTION-DDR) CCTG-PR-25 NCT06439225.
TPS5122 Background: For patients (pts) with mCRPC there are numerous treatment options including single agent docetaxel after treatment with androgen rece...
Personalized targeted glioblastoma therapies by <i>ex vivo</i> drug screening: Advanced brain tumor therapy clinical trial (ATTRACT).
TPS2097 Background: Targeted therapies used in a personalized treatment concept have revolutionized the management of several solid cancers. So far, vario...
Enhancing variant interpretation in hereditary cancer testing with RNA analysis from residual blood samples.
e22595 Background: Functional RNA studies can enable definitive classification for DNA variants of uncertain significance (VUS) identified via hereditary...
Modified four-quadrant enhanced coloanal anastomosis (fqeCAA) for patients receiving intersphincteric resection.
e15620 Background: Intersphincteric resection (ISR) is a sphincter-preserving surgery for ultra-low rectal cancer (uLRC). The anastomosis techniques for I...