Journal of Clinical Oncology
Articles in this Issue
The impact of early versus late palliative care referral (PCR) on healthcare utilization in pancreatic cancer patients: A single-center retrospective study.
12092 Background: Pancreatic cancer is one of the most aggressive malignancies, imposing substantial physical, psychosocial, and financial stress that sig...
Performance of a targeted enzymatic methylation-based early detection test by different colorectal cancer subgroups.
3596 Background: Colorectal cancer (CRC) is the second most frequently diagnosed cancer in China and early detection could prevent over 90% of CRC-related...
Multiomic evaluation of TEV-56278, a PD-1-targeted attenuated IL-2 molecule, in a human ex vivo tumor model and association with immune activation with enhanced effector CD8 T cell selectivity.
e14506 Background: Interleukin-2 (IL-2) is critical for cancer immunity, but its therapeutic use is limited by systemic toxicity and a narrow therapeutic...
Sexual health communication and young-onset cancer (YOC): Healthcare practitioners’ attitudes and practices.
12113 Background: Sexual health-related discussions are often challenging for Healthcare Practitioners (HCPs) and patients, making sexual health communica...
Broadening the gates: Analysis of potentially modifiable screen failures in pancreatic and biliary tract cancer trials.
e23011 Background: Eligibility criteria for clinical trials are crucial for maintaining safety and study integrity. However, they often exclude patients d...
Fc-engineered anti-CD9 antibodies with reducing platelet toxicity and efficacy against acute lymphoblastic leukemia.
e14501 Background: While CD19/CD22-targeted immunotherapies have advanced, treatment outcomes for patients with relapsed or refractory acute lymphoblastic...
In-hospital outcomes of sepsis in patients with diffuse large B-cell lymphoma: Insights from National Inpatient Sample.
e19077 Background: Per the Sepsis-3 guidelines published in 2016, sepsis was defined as a life-threatening organ dysfunction caused by a dysregulated host...
Trend of non-small cell lung cancer in young people.
e20509 Background: Non-small cell lung cancer (NSCLC) in young individuals is a rising concern, challenging the traditional understanding of the disease....
Updated results of the ALTER-E00 study: Efficacy and safety of anlotinib combined with radiotherapy in patients with locally advanced or metastatic esophageal squamous cell carcinoma (ESCC): A multi-center, multi-cohort retrospective exploratory study.
e16110 Background: Therapeutic options for metastatic esophageal squamous cell carcinoma (ESCC) primarily involve immunotherapy combined with chemotherapy...
C3NIRA: Randomized phase II study of carboplatin-cabazitaxel-cetrelimab (anti-PD-1) induction followed by niraparib +/- cetrelimab maintenance in men with aggressive variant prostate cancers (AVPC).
5008 Background: AVPC have limited therapeutic options and a dismal prognosis. Although early data indicate that adding carboplatin (Carb) to cabazitaxel...
Trends in adrenocortical cancer mortality in the US from 1999 to 2020: Regional, demographic and geographic disparities.
e23069 Background: Adrenal masses can be either benign or malignant, with adrenocortical carcinomas, being much less common than adrenal adenomas, having...
The identification of facilitators and barriers in the (pre-)emergency care pathway by patients with cancer and their caregivers.
e23162 Background: Up to 27% of patients with cancer receiving systemic therapy present to the emergency department (ED), often with long-standing disease...
Precision oncology in pediatric brain tumors: Real world experience from a middle income country.
e22015 Background: Despite the improvements in survival, treatment of recurrent/refractory (RR) central nervous system (CNS) tumors is challenging. Biolog...
The impact of a second primary cancer diagnosis on health-related quality of life in African American cancer survivors.
11133 Background: Survival for the most common cancers has improved dramatically over the past several decades due to advances in treatment and screening...
NuGenA (Nurse Led Genetic Counselling and Awareness): A proof-of-concept to implementation of genetic counseling for HBOC in LMICs.
10583 Background: Poor access to genetic testing and counselling represents a major gap in cancer care in resource-restricted-settings. Our pilot work in...
Real-life efficacy and safety data of lorlatinib treatment in ROS-1–positive advanced non-small cell lung cancer: Turkish Oncology Group (TOG) study.
e20659 Background: ROS-1-positive non-small cell lung cancers (NSCLCs) are rare, accounting for approximately 1-2% of all NSCLCs. Lorlatinib is a potent,...
Triplet therapy for FLT3-mutated acute myeloid leukemia in Puerto Rico: A retrospective study.
e18534 Background: Acute myeloid leukemia (AML) is a highly heterogeneous disease frequently driven by mutations in the FMS-like tyrosine kinase 3 (FLT3)...
Efficacy and safety of surufatinib (S) plus KN046 (K) and chemotherapy in first line (1L) advanced pancreatic cancer (PC): A single-arm, phase 1b/2 trial.
4157 Background: Gemcitabine (G) and nab-paclitaxel (nP) are standard 1L regimen for patients (pts) with unresectable PC, yet the efficacy remains unsatis...
Acute circulating tumor DNA dynamics during and after infusional therapy initiation.
1099 Background: For patients with advanced breast cancer, the proportion of tumor-derived DNA in circulation (‘tumor fraction’/TF) has been shown to be p...
Temporal trends of mortality due to laryngeal cancer among older adults in United States: A CDC WONDER analysis on gender, race, and geographical disparities.
e18037 Background: Laryngeal cancer is a significant global health burden arising in supraglottic or glottic regions and accounts for 33% of head and neck...
Use of brain protein I3 (BRI3) to predict disease fate in glioblastoma.
2047 Background: Genome-wide characterization has illuminated the molecular complexity of human gliomas. Genetic alterations help predict the clinical beh...
Effect of a daily scrum at the gastrointestinal oncology ward on length of stay: A tertiary center experience.
e13540 Background: The disease course of oncology patients often results in repeated hospitalization and prolonged length of stay (LOS). Next to disease a...
Deep learning–powered H&E whole-slide image analysis of endothelial cells to characterize tumor vascular environment and correlate treatment outcome to immunotherapy.
2578 Background: Beyond their vascular function, endothelial cells (ECs) regulate tumor growth through recently described angiocrine signaling, influencin...
Relevance and specificity of the French CIAN LUNG cohort for clinical research analyses in lung cancer using real-world data.
e23314 Background: Lung cancer, particularly non-small cell lung cancer (NSCLC), remains a leading cause of cancer-related mortality worldwide. Conducting...
Comparison of cancer study enrollments between urban, rural, frontier and remote participants.
e13749 Background: In the United States (US), less than 5% of patients participate in cancer research studies, with community sites that serve rural parti...