Journal of Clinical Oncology
Articles in this Issue
Survival and predictors of mortality among patients with virus-associated cancers in a high HIV-prevalence region in Kenya: A 10-year retrospective study.
e22529 Background: Virus-associated cancers cause significant mortality in Africa. Understanding risk factors for mortality is crucial for effective preve...
Transcriptome classification of PTEN inactivation to predict survival benefit from docetaxel at start of androgen deprivation therapy (ADT) for metastatic prostate cancer (PC): An ancillary study of the STAMPEDE trials.
5003 Background: Docetaxel (Doce) is effective for metastatic (M1) PC but its effect is varied. Combining Doce and hormone...
Perception of women with breast cancer regarding patient navigation services served at the Western Amazon reference hospital in Brazil.
e23175 Background: Patient navigation service (PNS) represents care focused on breast cancer patients, with the primary aim of guiding these women through...
Long-term clinical outcomes with nivolumab/ipilimumab with or without <i>Clostridium butyricum</i> MIYAIRI588 in metastatic renal cell carcinoma (mRCC): A randomized phase Ib clinical trial.
4550 Background: In two randomized phase I trials, Clostridium butyricum MIYAIRI58...
Real-world use of accelerated approval oncology drugs subsequently withdrawn in the United States.
e13573 Background: In 1992, the FDA launched the accelerated approval (AA) program using surrogate outcomes to expedite access to drugs for patients with...
Malignant neoplasms of central nervous system: Demographic and geographical disparities in the United States from 1999-2022.
e14024 Background: With an average 5-year survival rate of 35.6%, malignant neoplasms of the Central Nervous System (CNS) are considered aggressive tumors...
Long-term continuous temperature monitoring at a community cancer center: Towards a new standard of care in oncology.
e13883 Background: The standard of care for fever detection in oncology relies on oral thermometer measurements, which contributes to delayed detection of...
Real-world patient management practices in responders to venetoclax for newly diagnosed acute myeloid leukemia.
6527 Background: Venetoclax (VEN) is approved for adult patients (pts) with newly diagnosed (ND) acute myeloid leukemia (AML) in combination with hypometh...
Evaluating artificial intelligence's (AI) clinical reasoning with skin cancer multiple-choice questions.
e21598 Background: While large language models (LLMs) like GPT-4 (OpenAI) and Claude Opus (Anthropic) perform well on general medical exams, limited data...
Predictors of locoregional recurrence among patients with breast cancer treated with breast-conserving therapy: New data from a retrospective cohort.
e12583 Background: Breast-conserving surgery (BCS) followed by radiotherapy has become the standard treatment for early-stage breast cancer. The primary c...
Immunotherapy with anti-PD-1 or PD-L1 in advanced ovarian cancer (OC): A meta-analysis of randomized trials.
5570 Background: Immunotherapy (IO) has shown promising results in several solid tumors, including gynaecological malignancies. While PARP inhibitors and...
IMpactMF, randomized, open-label, phase 3 trial of imetelstat (IME) versus best available therapy (BAT) in patients (pts) with intermediate-2 (INT-2) or high-risk (HR) myelofibrosis (MF) relapsed or refractory (R/R) to Janus kinase inhibitors (JAKi).
TPS6588 Background: IME is a first-in-class telomerase inhibitor approved in 2024 for pts with transfusion-dependent lower-risk myelodysplastic syndromes...
Survival outcomes of patients with bladder cancer and lymph node metastases: Analysis based on a large oncology registry.
e16573 Background: Bladder cancer with lymph node metastases (BCLM) is associated with poor overall survival (OS). The management of patients with BCLM is...
Association of 8-gene signature with early recurrence in resected non-small cell lung cancer.
8031 Background: Limited evidence exists defining a genetic signature associated with early-recurrence in patients with non-small cell lung cancers (NSCLC...
Trends in gastrointestinal cancer and metabolic syndrome mortality in the US (1999–2023).
e23054 Background: Gastrointestinal (GIT) cancers and metabolic syndrome contribute significantly to mortality. This study examines trends in mortality fr...
Outcomes in patients with B-cell precursor acute lymphoblastic leukemia receiving inotuzumab ozogamicin stratified by body mass index.
6541 Background: Inotuzumab ozogamicin (InO) is approved for the treatment of adults for relapsed/refractory B-cell precursor acute lymphoblastic leukemia...
Analysis of clinical characteristics and immunotherapy outcomes in Chinese patients with Merkel cell carcinoma.
e21507 Background: Merkel cell carcinoma (MCC) is a rare neuroendocrine tumour of cutaneous origin. Due to its high malignancy and low incidence, few pros...
Predictors and clinical outcomes of CMV reactivation in CAR-T therapy: A systematic review.
2543 Background: Cytomegalovirus (CMV) reactivation is a common complication in immunocompromised patients, particularly those undergoing chimeric antigen...
Unveiling inequities: Racial disparities in MACCE outcomes among esophageal cancer patients.
e16165 Background: Esophageal cancer is a highly lethal malignancy with significant racial and ethnic disparities in clinical outcomes and healthcare util...
Impact of surgical delay beyond 8 weeks on tumor progression and lymph node involvement in early breast cancer: Insights from the KHRONOS Project.
e12552 Background: Recent evidence highlights a potential negative impact of delaying surgery for early breast cancer (BC) beyond 8 weeks; however, the in...
Analysis of racial demographic reporting in clinical studies supporting NCCN Small Cell Lung Cancer guidelines.
e13784 Background: Racial and ethnic disparities in cancer care persist, with Black individuals facing higher lung cancer incidence (15%) and mortality ra...
Treatment patterns and outcomes of head and neck cancer in sub-Saharan Africa: Insights from a multi-institutional cancer dataset.
e18017 Background: Head and neck (H&N) cancers affect the oral cavity, pharynx, larynx, salivary glands, nasal cavity, and sinuses. In Sub-Saharan Afr...
Implementation of clinical trial communication skills training for oncology fellows.
9026 Background: Effective physician-patient communication about cancer clinical trials (CCTs) is critical for improving participation, particularly in un...
Phase II study evaluating olutasidenib and azacitidine in patients with <i>IDH1</i> -mutated higher-risk myelodysplastic syndromes, chronic myelomonocytic leukemia, or advanced myeloproliferative neoplasms.
TPS6586 Background: IDH1 mutations are detected in 3-4% of patients with myelodysplastic syndromes (MDS) or chronic myelomonocytic leukemia (C...
Gender-specific trends in incidence and prevalence of pancreatic cancer: A Global Burden of Disease analysis in adults aged 70 and older (1990–2021).
e16410 Background: Pancreatic cancer (PC), once considered rare, has emerged as a significant contributor to global cancer mortality. This study examines...