Journal of Clinical Oncology
Articles in this Issue
Long-term oncological implications of hormone-replacement therapy in women with Kallmann syndrome: A propensity-matched study from the Global Federated Health Research Network.
e22525 Background: Kallmann syndrome is a rare genetic condition known for its characteristic hypogonadotropic hypogonadism and anosmia. Kallmann syndrome...
Analysis of a large language model-based system versus manual review in clinical data abstraction and deduction from real-world medical records of patients with melanoma for clinical trial eligibility assessment.
1571 Background: Manual chart review (MCR) is the gold standard for assessment of information from electronic medical reco...
Barriers and facilitators to seeking care for the initial diagnosis of melanoma in an urban safety-net hospital.
e23123 Background: Unlike locally advanced melanoma, early-stage melanoma is highly curable. Yet, despite increased efforts that promote recognition of ea...
Safety and efficacy of a small-molecule c-Myc degrader WBC100 in solid tumors: A first-in-human, phase I trial.
3120 Background: c-Myc amplification or overexpression is involved in the development and progression of many human cancers, and is often asso...
A quality initiative focused on biomarker testing in stage IB-IIIA resected and stage IV non-small cell lung cancer patients.
e13563 Background: The NCCN guidelines recommend non-small cell lung cancer (NSCLC) patients (pts) who are stage IB-IIIA (E-Stg) who have been resected to...
Concordance of parent-of-origin predictions for hereditary cancer variants using proband-only analysis.
10595 Background: Determining the parental origin of germline variants is a critical gap in clinical genetics, essential for risk management, variant clas...
Evaluating generative AI models for development of patient education quizzes on hormone-related symptoms of cancer therapy.
e13880 Background: To assess whether generative AI models can effectively design patient-appropriate educational quizzes on hormone-related symptoms of ca...
Prognostic significance of preoperational circulating tumor DNA detection in early-stage NSCLC using a tissue-free blood test.
3045 Background: There is a growing need for risk evaluation and treatment monitoring in cancer care. However, current methods, mainly imaging, can be bur...
Phase 2 dose expansion study of DSP107, a first-in-class bi-specific 4-1BB T-cell engager, with and without atezolizumab in metastatic MSS colorectal cancer patients.
3517 Background: DSP107 is a bi-specific fusion protein composed of sequences from the extracellular domain of SIRPα and 4-1BBL. The SIRPα arm selectively...
Health-related quality of life in metastatic hormone sensitive prostate cancer (mHSPC): Insights from a network meta-analysis of treatment options.
e17092 Background: Health-related quality of life (HRQoL) directly impacts both disease control outcomes and the patient experience playing a significant...
MRD negativity after end of induction in the phase 3 PhALLCON trial: A post hoc analysis.
6510 Background: The phase 3 PhALLCON trial (NCT03589326) in adults with newly diagnosed Ph+ ALL met its primary endpoint, showing a significantly higher...
Clinical characteristics, molecular landscape and survival outcomes of metastatic pancreatic cancer from western India.
e16401 Background: Pancreatic cancer is an aggressive malignancy often diagnosed at an advanced, metastatic stage, leading to poor prognosis....
Safety and efficacy of sintilimab versus pembrolizumab in the treatment of advanced or recurrent pediatric malignancies: A real-world study in China.
e22010 Background: PD-1 inhibitors have shown durable response and mild adverse events in adult malignancies. Studies of a direct comparison of distinct P...
Trastuzumab deruxtecan (T-DXd) in HER2-positive advanced breast cancer (ABC) with active CNS metastases: Real world data.
e13024 Background: T-DXd is considered one of the promising agents for the treatment of HER2+ ABC including patients (pts) with metastases (mts) to the CN...
Barriers and challenges for precision medicine and evidence-based oncology in genitourinary tumors in Latin America: insights from the LACOG 1024 survey CIELO.
e23041 Background: Precision medicine and evidence-based oncology are cornerstones of modern cancer care, enabling personalized treatment strategies. Howe...
Testosterone replacement therapy for fatigue, sexual dysfunction, and quality of life in older men with cancer (TEMEC).
TPS12138 Background: Fatigue is prevalent in men with cancer, affecting 70-100% of survivors. Fatigue impairs quality of life (QOL), increases caregiver b...
Sintilimab plus bevacizumab, oxaliplatin, and capecitabine as perioperative therapy in microsatellite-stable, resectable colorectal cancer liver metastases: An open-label, single-arm, phase II trial.
3586 Background: Immunotherapy has revolutionized cancer treatment, yet its efficacy in proficient mismatch repair and/or microsatellite stable (pMMR/MSS)...
A network meta-analysis (NMA) of efficacy of zanubrutinib versus fixed-duration acalabrutinib plus venetoclax in treatment-naïve (TN) chronic lymphocytic leukemia (CLL).
e19031 Background: While the efficacy of zanubrutinib (ZANU) has been evaluated in the phase 3 SEQUOIA trial (NCT03336333), and the combination regimen of...
Efficacy and safety of donafenib combined with interventional therapy and with/without immunotherapy in hepatocellular carcinoma: A retrospective study.
e16177 Background: The Phase III clinical trial ZGDH 3 and several real-world studies have demonstrated the potential of Donafenil to improve overall surv...
Physical rehabilitation program for cardiorespiratory health and quality of life among breast cancer survivors: A randomized control trial.
e12500 Background: Breast cancer treatment has improved significantly, contributing to a 5-year relative survival rate of 99% for localized cases. However...
Disparities in time to completion of multi-target stool DNA testing: A retrospective study across a statewide population.
e13762 Background: Colorectal cancer screening using non-invasive methods like the multi-target stool DNA test(Exact Sciences, Madison, WI) is an emerging...
Camrelizumab combined with cetuximab and chemotherapy in recurrent or metastatic head and neck squamous cell carcinoma (R/M HNSCC): 1-year outcomes from the phase II trial.
6030 Background: Pembrolizumab or cetuximab combined with platinum-based-chemo are standard first-line regimen for R/M HNSCC, but the efficacy is far from...
Lighting up PNET: Creating murine models with a novel bioluminescent cell line.
e16352 Background: Pancreatic neuroendocrine tumors (PNETs) are rare malignancies characterized by dysregulation of complex molecular signaling pathways....
Splicing factor 3B subunit 1A (SF3B1) mutations in lymphoid malignancies.
e23315 Background: Advancements in genetic profiling are paving the way to personalized medicine by identification of mutations across all tumor types, he...
Actionable insights: Liquid NGS in community oncology practice.
e15081 Background: Liquid-based next-generation sequencing (NGS) is an integral test alongside tissue biopsy for identifying actionable mutations in vario...