Nature Communications
Articles in this Issue
In depth transcriptomic profiling defines a landscape of dysfunctional immune responses in patients with VEXAS syndrome
Abstract VEXAS (Vacuoles, E1 enzyme, X-linked, Autoinflammatory, Somatic) syndrome is caused by inactivating somatic mutations in the UBA1 gene. Here, we characterize the immunological lands...
Suppressing COx in oxidative dehydrogenation of propane with dual-atom catalysts
Cavity quantum electrodynamics with moiré photonic crystal nanocavity
Grain boundary amorphization as a strategy to mitigate lithium dendrite growth in solid-state batteries
A molecularly engineered large-area nanoporous atomically thin graphene membrane for ion separation
Author Correction: A plant Bro1 domain protein BRAF regulates multivesicular body biogenesis and membrane protein homeostasis
Optimized AAV capsids for basal ganglia diseases show robust potency and distribution
Three distinct strategies lead to programmable aliphatic C−H oxidation in bicyclomycin biosynthesis
Abstract The C−H bond functionalization has been widely used in chemical synthesis over the past decade. However, regio- and stereoselectivity still remain a significant challenge, especiall...
Engineering flexible superblack materials
Abstract Flexible superblack materials are crucial for minimizing stray light, complicating object identification, and serving as low reflectance standards. However, the applications of exis...
DNA replication timing reveals genome-wide features of transcription and fragility
Abstract DNA replication in humans requires precise regulation to ensure accurate genome duplication and maintain genome integrity. A key indicator of this regulation is replication...
Excitonic topology and quantum geometry in organic semiconductors
Abstract Excitons drive the optoelectronic properties of organic semiconductors which underpin devices including solar cells and light-emitting diodes. Here we show that excitons can exhibit...
Single-cell RNA-sequencing reveals early mitochondrial dysfunction unique to motor neurons shared across FUS- and TARDBP-ALS
Abstract Mutations in FUS and TARDBP cause amyotrophic lateral sclerosis (ALS), but the precise mechanisms of selective motor neuron degeneration remain unresolved. To address if pat...
Stabilizing brain-computer interfaces through alignment of latent dynamics
Molecular simulations of enzymatic phosphorylation of disordered proteins and their condensates
Abstract Condensation and aggregation of disordered proteins in cellular non-equilibrium environments are shaped decisively by enzymes. Enzymes called kinases ph...
Structural reconfiguration of interacting multi-particle systems through parametric pumping
Dual Ribosome Profiling reveals metabolic limitations of cancer and stromal cells in the tumor microenvironment
Abstract The tumor microenvironment (TME) influences cancer cell metabolism and survival. However, how immune and stromal cells respond to metabolic stress in vivo, and how nutrient...
Copper-catalyzed photoinduced carbonylation of C1-C3 gaseous alkanes
Engineering anti-BCMA CAR T cells for enhancing myeloma killing efficacy via apoptosis regulation
Rotational orientation control of a ground state ortho-H2 dissociation on a metal surface
Abstract When hydrogen molecules collide with a surface, they can either scatter away from the surface or undergo dissociative chemisorption. The relative probabilities of these different ou...
Extending Minds with Generative AI
Efficient coupling of topological photonic crystal waveguides based on transverse spin matching mechanism
Intestinal permeability of N-acetylcysteine is driven by gut microbiota-dependent cysteine palmitoylation
A tungsten polyoxometalate mediated aqueous redox flow battery with high open-circuit voltage up to 2 V
Abstract As a promising stationary energy storage device, aqueous redox flow battery (ARFB) still faces the challenge of low open-circuit voltage, due to the lim...
Transcriptional and epigenetic rewiring by the NUP98::KDM5A fusion oncoprotein directly activates CDK12
Abstract Nucleoporin 98 (NUP98) fusion oncoproteins are strong drivers of pediatric acute myeloid leukemia (AML) with poor prognosis. Here we show that NUP98 fusion-expressing AML harbors an...
Epstein–Barr virus induces aberrant B cell migration and diapedesis via FAK-dependent chemotaxis pathways
Abstract Infection with the Epstein-Barr virus (EBV) is a major risk factor for the development of cancer and autoimmune disorders. The virus enters the body in...