Nature Communications
Articles in this Issue
Cation-self-shielding strategy promises high-voltage all-Prussian-blue-based aqueous K-ion batteries
Dermatologist-like explainable AI enhances melanoma diagnosis accuracy: eye-tracking study
Abstract Artificial intelligence (AI) systems substantially improve dermatologists’ diagnostic accuracy for melanoma, with explainable AI (XAI) systems further enhancing their confidence and...
Author Correction: Huntington’s disease cellular phenotypes are rescued non-cell autonomously by healthy cells in mosaic telencephalic organoids
Wnt signalosome assembly is governed by conformational flexibility of Axin and by the AP2 clathrin adaptor
Abstract Wnt signal transduction relies on the direct inhibition of GSK3 by phosphorylated PPPSPxS motifs within the cytoplasmic tail of the LRP6 co-receptor. How GSK3 is recruited to LRP6 r...
The latent cis-regulatory potential of mobile DNA in Escherichia coli
Reconfigurable terahertz optoelectronic logic through charge-density-wave phase engineering
Multi-omics analysis of SFTS virus infection in Rhipicephalus microplus cells reveals antiviral tick factors
Abstract The increasing prevalence of tick-borne arboviral infections worldwide necessitates advanced control strategies, particularly those targeting vectors, t...
Switchable narrow nonlocal conducting polymer plasmonics
Abstract Dynamically switchable surface plasmons in conducting polymers constitute an emerging route towards intelligent metasurfaces, but polymer plasmons have...
Redox-active electrolyte-based printed ionologic devices
Abstract Ionic devices, such as electrochemical capacitor diodes (CAPodes) and gate-controlled CAPodes with transistor-like gating characteristics (G-CAPodes), offer a novel approach to ener...
H/ACA snR30 snoRNP guides independent 18S rRNA subdomain formation
Abstract Ribosome biogenesis follows a cascade of pre-rRNA folding and processing steps, coordinated with ribosomal protein incorporation. Nucleolar 90S pre-ribosomes are well-described stab...
Cyclic peptide structure prediction and design using AlphaFold2
Deciphering signaling mechanisms and developmental dynamics in extraembryonic mesoderm specification from hESCs
Abstract Extraembryonic mesoderm (ExM) is crucial for human development, yet its specification is poorly understood. Human embryonic stem cell (hESC)-based models, including embryoids and di...
No compromise in efficiency from the co-application of a marine and a terrestrial CDR method
Abstract Modelled pathways consistent with the Paris Agreement goals to mitigate warming typically include the large-scale application of Carbon Dioxide Removal (CDR), which can include both...
Reveal genomic insights into cotton domestication and improvement using gene level functional haplotype-based GWAS
Mpox multiprotein virus-like nanoparticle vaccine induces neutralizing and protective antibodies in mice and non-human primates
Abstract The upsurge of mpox in Africa and the recent global outbreak have stimulated the development of new vaccines and therapeutics. We describe the construction of virus-like particle (V...
APOBEC affects tumor evolution and age at onset of lung cancer in smokers
Abstract Most solid tumors harbor somatic mutations attributed to off-target activities of APOBEC3A (A3A) and/or APOBEC3B (A3B). However, how APOBEC3A/B enzymes affect tumor evolution in the...
Nickel-embedded three-in-one pyridyl-quinoline-linked covalent organic framework photocatalysts for universal C(sp2) cross-coupling reactions
A searchable atlas of pathogen-sensitive lncRNA networks in human macrophages
Abstract Long noncoding RNAs (lncRNA) are crucial yet underexplored regulators of human immunity. Here we develop GRADR, a method integrating gradient profiling with RNA-binding proteome ana...
Global DNA methylation differences involving germline structural variation impact gene expression in pediatric brain tumors
Corticothalamic neurons in motor cortex have a permissive role in motor execution
Abstract The primary motor cortex (M1) is a central hub for motor learning and execution. M1 is composed of heterogeneous cell types with varying relationships t...
Deciphering the history of ERK activity from fixed-cell immunofluorescence measurements
Abstract The RAS/ERK pathway plays a central role in diagnosis and therapy for many cancers. ERK activity is highly dynamic within individual cells and drives cell proliferation, met...
Parallelizing analog in-sensor visual processing with arrays of gate-tunable silicon photodetectors
Abstract In-sensor processing of dynamic and static information of visual objects avoids exchanging redundant data between physically separated sensing and computing units, holding promise f...
Gonadotrophs have a dual origin, with most derived from early postnatal pituitary stem cells
Abstract Gonadotrophs are the essential pituitary endocrine cells for reproduction. They produce both luteinizing (LH) and follicle-stimulating (FSH) hormones that act on the gonads to promo...
Robust prediction of synthetic gRNA activity and cryptic DNA repair by disentangling cellular CRISPR cleavage outcomes
Abstract The ability to robustly predict guide RNA (gRNA) activity is a long-standing goal for CRISPR applications, as it would reduce the need to pre-screen gRNAs. Quantification of formati...