Nature Communications
Articles in this Issue
Developing serum proteomics based prediction models of disease progression in ADPKD
Abstract Autosomal Dominant Polycystic Kidney Disease is the most common genetic cause of kidney failure. Outcome prediction is essential to guide therapeutic decisions. However, cur...
Nanoscale 3D DNA tracing in non-denatured cells resolves the Cohesin-dependent loop architecture of the genome in situ
Abstract The spatial organization of the genome is essential for its functions, including gene expression and chromosome segregation. Phase separation and loop extrusion have been proposed t...
Natural variation of an E3 ubiquitin ligase encoding gene Chalk9 regulates grain chalkiness in rice
A universal approach for thin high-entropy oxides regulated by Ga2O3 layers for oxygen evolution reaction
Plasma proteomics for biomarker discovery in childhood tuberculosis
Abstract Failure to rapidly diagnose tuberculosis disease (TB) and initiate treatment is a driving factor of TB as a leading cause of death in children. Current TB diagnostic assays have poo...
Precise control of selective nitrogen atom insertion into five-membered cyclic β-ketoesters
Single cell and spatial alternative splicing analysis with Nanopore long read sequencing
A data-to-forecast machine learning system for global weather
A solid-solution approach for controllable photomechanical crystalline materials
A universal and versatile terahertz field manipulation mechanism by manipulating near-infrared phases with a dislocation scheme
Nanomechanical binding mechanism of ligands drives agonistic activity
Abstract Monoclonal antibodies and ligands targeting CD40 exhibit a wide range of agonistic activities and antitumor responses. Studies have shown that the flexibility and affinity of antibo...
Calcium transients regulate the apical emergence of basally located progenitors during Xenopus skin development
Abstract The integration of basally located progenitors into an existing epithelium, termed apical emergence, is crucial for the morphogenesis and homeostasis of epithelial tissues and organ...
Sub-nanosecond all-optically reconfigurable photonics in optical fibres
Abstract Reconfigurable photonic systems provide a versatile platform for dynamic, on-demand control and switching. Here we introduce an all-optical platform in multimode and multico...
Cardiomyocyte OTUD1 drives diabetic cardiomyopathy via directly deubiquitinating AMPKα2 and inducing mitochondrial dysfunction
Characterisation of between-cluster heterogeneity in malaria cluster randomised trials to inform future sample size calculations
Abstract Cluster randomised trials (CRTs) are important tools for evaluating the community-wide effect of malaria interventions. During the design stage, CRT sample sizes need to be...
Scalable synthesis of phosphorescent SiO2 nanospheres and their use for angle-dependent and thermoresponsive photonic gels with multimode luminescence
Abstract Developing room-temperature phosphorescent (RTP) materials with microscale periodic structures presents a promising prospect for future optical applicat...
Cobalt catalyst with exclusive metal-centered chirality for asymmetric photocatalysis
Abstract For decades, progress in chiral transition metal catalysis has been closely linked to the design of tailor-made chiral ligands. Recently, an alternative to this conventional paradig...
Targeting CD37 promotes macrophage-dependent phagocytosis of multiple cancer cell types and facilitates tumor clearance in mice
Silicon nanocolumn-based disposable and flexible ultrasound patches
ATG8ylation-mediated tonoplast invagination mitigates vacuole damage
Defect-tolerant electron and defect-sensitive phonon transport in quasi-2D conjugated coordination polymers
Abstract Thermoelectric materials, enabling direct waste-heat to electricity conversion, need to be highly electrically conducting while simultaneously thermally insulating. This is fundamen...
The potassium channel K2P2.1 shapes the morphology and function of brain endothelial cells via actin network remodeling
Abstract K2P2.1 (gene: Kcnk2), a two-pore-domain potassium channel, regulates leukocyte transmigration across the blood-brain barrier by a yet unknown mechanism. We demonstrate that Kcnk2...
Multi-component reactions via copper(I) difluorocarbene as carbonyl source for constructing α—aminoamide derivatives
Abstract Difluorocarbene, an important reactive intermediate in organic synthesis, exhibits intriguing properties and synthetic versatility. However, great challenges in modulating reaction...
Ultra-sensitive metaproteomics redefines the dark metaproteome, uncovering host-microbiome interactions and drug targets in intestinal diseases
Abstract The functional characterization of host-gut microbiome interactions remains limited by the sensitivity of current metaproteomic approaches. Here, we present uMetaP, an ultra-sensiti...