Nature Communications
Articles in this Issue
Specific oncogene activation of the cell of origin in mucosal melanoma
Salmonella Typhi gut invasion drives hypoxic immune subsets associated with disease outcomes
PFKM phosphorylates histone H3 and promotes mitotic progression by sensing the levels of citrate
Machine learning in Alzheimer’s disease genetics
Abstract Traditional statistical approaches have advanced our understanding of the genetics of complex diseases, yet are limited to linear additive models. Here we applied machine learning (...
Protein design of two-component tubular assemblies similar to cytoskeletons
Abstract Recent advances in protein design have ushered in an era of constructing intricate higher-order structures. Nonetheless, orchestrating the assembly of diverse protein units...
Decoupling fast hydrogen oxidation reaction on a tandem electrocatalyst
Transdifferentiation of tongue muscle cells into cancer-associated fibroblasts in response to tongue squamous cell carcinoma
Summer warming in the East Antarctic interior triggered by southern Indian Ocean warming
Theoretical and quantum mechanical deconstruction of vibrational energy transfer pathways modified by collective vibrational strong coupling
Intermolecular Coulombic decay in liquid water competes with proton transfer and non-adiabatic relaxation
Abstract Despite decades of research, our understanding of radiation damage in aqueous systems remains limited. The recent discovery of Intermolecular Coulombic Decay (ICD) following inner-v...
Quantitative evaluation of methods to analyze motion changes in single-particle experiments
Abstract The analysis of live-cell single-molecule imaging experiments can reveal valuable information about the heterogeneity of transport processes and interactions between cell components...
Beyond the samples: Nigerian research staff perspectives on a multicentre neonatal sepsis study’s impact
Sustainable Bi-directional thermoregulation fabric for clothing microclimate
Heteroatom dopants overcome the activity-stability trade-off in RuO2 for acidic oxygen evolution
Mechanism of Rad51 filament formation by Rad52 and Rad55-Rad57 in homologous recombination
Structural host-virus interactome profiling of intact infected cells
Abstract Virus-host protein-protein interactions (PPIs) are fundamental to viral infections, yet high-resolution identification of their structural and molecular determinants within...
The hit-and-run of cell wall synthesis: LpoB transiently binds and activates PBP1b through a conserved allosteric switch
Reconstitution of circadian clock in synthetic cells reveals principles of timekeeping
Abstract The cyanobacterial circadian clock maintains remarkable precision and synchrony, even in cells with femtoliter volumes. Here, we reconstitute the KaiABC post-translational o...
Super-resolution femtosecond electron diffraction reveals electronic and nuclear dynamics at conical intersections
Diversity and transmission and zoonotic potential of microbes in true insectivores
Extraction of valuable metals from acid mine drainage by an electrochemically activated limestone system
Geopolymerization threatens the persistence of organic carbon associated with iron in anoxic environments
Estimation-uncertainty affects decisions with and without learning opportunities
Abstract Motivated behavior during reinforcement learning is determined by outcome expectations and their estimation-uncertainty (how frequently an option has been sampled), with the latter...
Allosteric activation of the SPRTN protease by ubiquitin maintains genome stability
Abstract The DNA-dependent protease SPRTN maintains genome stability by degrading toxic DNA-protein crosslinks (DPCs). To understand how SPRTN’s promiscuous protease activity is conf...