Nature Communications
Articles in this Issue
VEGFR2 is required for VEGF-C–VEGFR3–PI3Kα-mediated sprouting lymphangiogenesis
Abstract Lymphatic vessels are essential for tissue homoeostasis and their growth is regulated by vascular endothelial growth factor C (VEGF-C) signalling through VEGFR3. However, ho...
Genotype epigenome phenotype integration reveals peripheral immune contributions to type I bipolar disorder
Abstract Immune dysfunction has been increasingly implicated in bipolar disorder, but the underlying mechanisms remain unclear. To address this, we profile 833 g...
Towards hepatitis C elimination with integrated risk-based screening and decentralized care in Taiwan
Filamentous morphology of influenza A virus confers enhanced stability in aerosols
Abstract Airborne transmission of influenza A virus (IAV) poses significant challenges to public health. However, the mechanisms governing viral inactivation in aerosols remain poorl...
Identification of a component of the tubulin poly-glutamylase complex required for phosphoinositide homeostasis and cilium assembly and maintenance
Local-high-concentration molecular catalysts enabled by covalent organic frameworks for rechargeable Li | |SOCl2 battery
Bridging sequence-structure motifs and genetic variants for genome-wide dynamic RNA-protein interaction profiling
Fast efficient coding and sensory adaptation in gain-adaptive recurrent networks
Limited meltwater potential in the Asian Water Tower to mitigate downstream urban scarcity
Integrated van der Waals waveguides for all-optical nonlinear photonic circuits
Dissecting epigenetic heterogeneity in single-cell DNA methylomes with a unified framework
Maveropepimut-S, pembrolizumab and low dose cyclophosphamide in metastatic ovarian cancer: phase 1/2 PESCO trial
SIRT6 overexpression counteracts chromatin aging in the male murine liver
α-Halothioamide warheads with enhanced cysteine reactivity and specificity for covalent protein labelling
Abstract Covalent labelling is a promising modality relying on electrophilic warheads that form covalent bonds with their targets. Here we present the oxygen-to-sulfur exchange strat...
Large-scale data-driven pre-trained DNA models enhance performance across diverse genomics tasks
Abstract Sequence-based deep learning has advanced genome interpretation, yet most models remain task-specific and rely on retraining, limiting scalability across biological contexts...
Platinum oxide formation under oxygen evolution reaction conditions
Abstract Electrocatalyst degradation, often caused by oxidative processes, forms a large barrier for the wide-spread application of electrolysers and fuel cells,...
Single-nucleus epigenomic dysregulation unmasks genetic risk-associated neurodegenerative glia states
Abstract The accumulation of abnormal tau protein selectively affects distinct brain regions and specific populations of neurons and glial cells in tau-related dementias, such as Alz...
m6A modification suppresses innate anti-tumour immunity in colorectal cancer by limiting alu-derived dsRNA accumulation
Abstract How cancer cells evade immune detection despite expressing immunostimulatory retroelement (RE) transcripts remains unclear. In cancer, endogenous REs th...
Modular small RNA drives the emergence of virulence traits and environmental trade-offs in Vibrio cholerae
Robust integration of single-cell datasets with imbalanced modality composition
Abstract Single-cell multimodal datasets often exhibit heterogeneous and incomplete modality coverage, posing a challenge for data integration known as mosaic integration. Here, we p...
Sub-diffractional infrared absorption of two-dimensional water
Abstract Several theoretical frameworks predict that water’s vibrational dynamics and dielectric properties undergo dramatic changes when confined to a monolayer. However, experiment...
Multiparameter quantum-enhanced adaptive metrology with squeezed light
Abstract Squeezed light enables quantum-enhanced phase estimation, with crucial applications in both fundamental physics and emerging technologies. To fully expl...