Nature Communications
Articles in this Issue
Unveiling the emission mechanism in analog-doped carbazole-based organic afterglow materials
Interplay of oxygen vacancies and lanthanide emitters enables reversible upconversion switching
Protein-based pan-RAS inhibitor induces tumor regression in female mice via IFNγ and CD8+ T cell-dependent tumor necrosis
Abstract Mutations in K/H/N-RAS occur in approximately 30% of human cancers, yet most RAS mutants remain undruggable in clinical settings. Here, we describe a pr...
Deciphering electrochemomechanical interplay in rechargeable aqueous Zn||MnO2 batteries
A phase II peri-operative study of pembrolizumab plus lenvatinib for mucosal melanoma
Abstract Mucosal melanoma is an aggressive malignancy with limited neoadjuvant options. We conducted a single arm, phase II study of neoadjuvant pembrolizumab pl...
EMReady2: improvement of cryo-EM and cryo-ET maps by local quality-aware deep learning with Mamba
The four voltage-sensing domains of T-type calcium channels activate near the resting membrane potential
Abstract Low-voltage-activated (LVA, T-type, or Ca V 3), calcium-selective channels open in response to modest depolariza...
H3K9me3 controls epidermis morphogenesis by regulating RNA Pol II dynamics at developmental promoters and enhancers
Abstract Histone H3K9me3 silences repetitive elements and represses non-lineage genes during early development, but its role in organogenesis is understudied. Here, we show that H3K9...
Self-grown mycelium in confined geometries as nanofluidic devices
Abstract Precise control of ion and molecular transport at the nanoscale underpins next-generation nanofluidic technologies. However, current approaches such as...
α-Synuclein aggregates induce mitochondrial damage and trigger innate immunity to drive neuron–microglia communication
Abstract Tunneling nanotubes (TNTs) enable direct intercellular transfer of macromolecules, organelles, and pathogenic protein aggregates. While...
Jets from a stellar-mass black hole are as relativistic as those from supermassive black holes
Organic-inorganic hybrid scintillating glass for high-energy particle detection
Mapping the spatiotemporal continuum of structural connectivity development across the human connectome in youth
Abstract Childhood and adolescence are marked by protracted developmental remodeling of cortico-cortical structural connectivity. However, the spatiotemporal var...
LTBP4 deficiency inhibits NLRP3 inflammasome activation in cardiomyocytes and attenuates heart failure in male mice
Divergence among species with “good competitor” and “good cultivator” strategies promotes asymmetric facilitation among co-invaders
Machine-learning guided engineering of Mo4+ activated halide near-infrared phosphors for AI-augmented medical imaging
CRISPR-based environmental detection of Burkholderia pseudomallei identifies sanitation gaps and melioidosis risk in northeast Thailand
Abstract Environmental exposure to Burkholderia pseudomallei , the causative agent of melioidosis, remains poorly charact...
Mesoporous peptide frameworks engineered from crystallizable collagen-mimetic peptide amphiphiles
Abstract The rational design of porous frameworks with tunable pore dimensions and chemical functionalities is a critical step toward their implementation in div...
Structural basis for RNA synthesis and inhibition of the orthobunyavirus polymerase
The actual Co(10-12) surface structure and CO activation
Naïve CD4+ T-cells and disease status at CART infusion correlate with clinical outcomes in real-world large B-cell lymphoma patients receiving second-line CAR T therapy
Dynamic variations of metal-O bonding in electro- and thermo-catalytic activation processes
Highly luminescent carbazole-functionalized tris(tribromophenyl)methyl radicals with stable circularly polarized photoluminescence
Abstract Brominated trityl radicals form stable enantiomers and present promising candidates for molecular qubits in spintronic and quantum technologies. However...
Photoinduced correlations in stochastic dynamics of a solid-state ionic conductor
Abstract Photoexcitation by ultrashort laser pulses plays a crucial role in controlling reaction pathways, creating nonequilibrium material properties, and probing complex molecular...
A robust physics-constrained neural operator framework for efficient geothermal resource development
Abstract Efficient evaluation of geothermal systems is critical for reliable and scalable development. However, conventional workflows are often constrained by t...