Nature Communications
Articles in this Issue
A deep learning ECG model for identification and localization of occlusion myocardial infarction
Abstract Rapid identification and localization of an acute coronary occlusion are vital to prevent myocardial damage, yet reliance on ST-segment ECG criteria misses many acute occlus...
Chromatin rewiring of β-globin and MYC enhancers by TGF-β1 drives defective erythropoiesis
Multi-phase hybrid metabolomics framework identifies clinically applicable plasma signatures for early detection of gastric cancer
Abstract Plasma metabolomics offers significant potential for non-invasive biomarker discovery in gastric cancer (GC), yet conventional analytical workflows face challenges in absolu...
Intrinsically stretchable large-area pixelated electrochromic displays via direct photopatterning
Wnt-dependent ontogeny of acellular cementum-forming cementoblasts on the tooth root surface
Abstract Cementum is a specialized mineralized tissue that covers the tooth root surface and anchors the tooth to the surrounding periodontal ligament. The cervi...
Hierarchical small molecule inhibition of MYST acetyltransferases
Abstract MYST lysine acetyltransferases (KATs) are a class of epigenetic enzymes critical for cellular function that constitute an emerging therapeutic target in cancer. Recently, se...
Variant U1 snRNAs contribute to cell cycle and differentiation control of human iPS cells
Abstract The maintenance of stem cell identity, as well as the differentiation of stem cells into any lineage, requires precise regulation of gene expression. Despite intensive resea...
Soluble bacterial lipopeptides suppress gasdermin D-associated IL-33 release in keratinocytes and atopic dermatitis in mice
Abstract The rising prevalence of allergic diseases over the last century has been linked to smaller families and the shift of populations from countryside to ci...
Structural basis of Ku-mediated activation of WRN exonuclease activity
Abstract Werner (WRN) is the only human RecQ helicase family member with DNA exonuclease activity. WRN promotes genome stability through its functions in DNA replication, repair and...
Structural basis for prohibitin-mediated regulation of mitochondrial m-AAA protease
A metasurface-enabled green-smart window for intelligent wireless communications with high visible transparency and low infrared emissivity
Abstract New-generation windows require advanced multi-physics modulation capability to accommodate diverse functions, including optical transparency, thermal insulation, and wireles...
Chemically coupled dual-interface self-regulation for perovskite solar cells
Manganese (Hydr)oxides record the dynamic evolution of a million-year Hesperian Ocean in Utopia Planitia, Mars
Personalized machine learning-guided radiation dose escalation in newly diagnosed glioblastoma: prospective pilot study
Real-space imaging and control of topological spin textures in a van der Waals antiferromagnet
Mechano-metabolic feedback connects tissue fluidity to mitochondrial DNA–dependent immunity in breast cancer
Cerebellar growth is associated with domain-specific cerebral maturation and socio-linguistic behavior
Abstract The cerebellum’s involvement in cognitive functions is increasingly recognized, yet its developmental contribution to cognition remains poorly understoo...
Targeted degradation of USP7 in solid cancer cells reveals distinct effects of deubiquitinase degraders and inhibitors
Abstract Proteolysis-targeting chimeras (PROTACs) co-op the ubiquitin system for targeted protein degradation, creating opportunities to interrogate cellular functions of proteins th...
Bending-fatigue-resistant hierarchical NiTi shape memory alloy
Integrated catalyst–transport nickel-iron porous electrode for anion exchange membrane water electrolysis
Selective and differential roles of PVHCRH neurotransmitters in diet-induced obesity in mice
Reprogramming gut microenvironment for the treatment of acute severe ulcerative colitis via a synergistic therapy of necroptosis blockade and organoid transplantation
Base modifications shift tertiary structure and activity in synthetic RNA origami and a natural ribozyme
A metal-DNA biohybrid as enantioselective artificial photoDNAzyme
Abstract Visible light photocatalysis, which exploits the reactivity of molecules at their excited state, has triggered a paradigm shift in organic synthesis by enabling some very un...