Journal of Clinical Oncology
Articles in this Issue
Language matters: Impact of medical interpretation on lung cancer screening adherence.
e13752 Background: Landmark trials like NLST, NELSON, DLCST, DANTE, PLCO, and LUSI have shown benefits of lung cancer screening (LCS) in early detection a...
Efficacy and safety of nivolumab and ipilimumab in treating metastatic colorectal cancer (mCRC): A systematic review and meta-analysis.
e15560 Background: Colorectal cancer is among the top three cancers in the world with approximately a million new cases each year globally. Immunotherapie...
Prognosis and survival evaluation in treating high-risk BRAF V600 mutation stage III or IV melanoma with dabrafenib plus trametinib therapy: A meta-analysis of 2,660 patients.
e21501 Background: Stage III and IV melanoma is a challenging entity due to its high mortality rate, rapid progression, and therapy resistance. For patien...
Ensartinib as postoperative adjuvant therapy in patients with ALK-positive non-small cell lung cancer (NSCLC): A registered, retrospective, real-world study.
8024 Background: Ensartinib has been approved as ALK-positive locally advanced/metastatic NSCLC, but its role in adjuvant therapy remains unknown. This re...
Evaluating the feasibility of a peer-support group for patients with cancer (presently).
12101 Background: Many patients with cancer experience significant mental health challenges (commonly depression, anxiety, and adjustment disorders) which...
Cervical cancer treatment trajectories in a sample of cervical cancer patients in the Democratic Republic of the Congo: A retrospective descriptive study.
e17519 Background: With limited curative-intent treatment options in the country, cervical cancer is the leading cancer in terms of mortality in the Democ...
Diagnosis, treatment, and outcomes of multiple myeloma in Armenia: A real-world experience from a developing country.
e19513 Background: In Armenia, multiple myeloma (MM) is one of the most frequent hematologic malignancies. The aim of this study is to evaluate diagnostic...
Comparative diagnostic accuracy of deep learning and hand-crafted radiomics models for detecting lymph node metastases in head and neck cancers: A meta-analysis.
e18023 Background: Accurate detection of lymph node metastases (LNM) is crucial in the management of head and neck cancers. Artificial intelligence (AI) t...
Immunoembolization for patients with uveal melanoma hepatic metastasis: A single-institution real-world data analysis.
9586 Background: Metastatic disease occurs in up to 50% of patients with uveal melanoma (UM) despite successful treatment of the primary eye tumor. The li...
Receiving a cancer diagnosis during hospitalization and associations with care outcomes.
11046 Background: Patients often receive their cancer diagnoses during a hospitalization, but little is known about patients who are diagnosed inpatient v...
Fixed duration subcutaneous (SC) mosunetuzumab (Mosun) in patients with previously untreated high-tumor burden follicular lymphoma (FL): Interim results from the phase II MorningSun study.
7014 Background: Mosun is a CD20xCD3 bispecific antibody that can be administered in the outpatient setting for a fixed duration. Intravenous Mosun is app...
Trajectories of clinical encounters among long-term lung cancer survivors: A SEER-Medicare cluster analysis.
e13633 Background: With improved lung cancer survival, there is a knowledge gap in the variations in clinical needs and healthcare utilization among long-...
Medical students’ interest and exposure to oncology in Nigeria: Implications for workforce development.
e21036 Background: Oncology workforce shortages pose a significant challenge to cancer care in low- and middle-income countries (LMICs). In Nigeria, a cou...
Differences in patient (pt) characteristics and therapy choice across treatment (tx) groups in locally advanced or metastatic urothelial cancer (la/mUC) in the US: A survey on unmet patient needs.
e16561 Background: Although the tx landscape for la/mUC has evolved with the emergence of novel therapies, a gap remains in understanding physician perspe...
Hyperthermic intraperitoneal chemotherapy (HIPEC) for primary advanced-stage or recurrent ovarian cancer: A systematic review and meta-analysis of randomized controlled trials.
5583 Background: Ovarian cancer is the gynecologic malignancy with the highest mortality rate. Despite cytoreductive surgery (CRS) and adjuvant or neoadju...
Immunoprofiling: A prospective multi-cohort study to characterize circulating immune response in advanced prostate cancer.
e17055 Background: The tumor immune microenvironment (TIME) is a critical determinant of therapeutic response and resistance mechanisms in prostate cancer...
Impact of clinical and socioeconomic factors on survival outcomes in non-small cell lung cancer: A retrospective analysis.
e13548 Background: Lung cancer is the most common cause of cancer-related mortality in the United States. Research suggests that not only clinical factors...
Differential genomic landscape of estrogen receptor (ER)-low versus ER-positive (ER+) and ER-negative (ER-) metastatic breast cancer (MBC).
1071 Background: Guidelines define ER+ breast cancer (BC) as ≥1% tumor nuclei staining positive by IHC. Data on managing ER-low tumors (1–10% ER staining)...
Temporal trends and disparities in pancreatic cancer mortality: A nationwide analysis from 1968-2020.
e16428 Background: Pancreatic cancer is among the most aggressive malignancies, with poor survival rates and a rising incidence globally. Understanding lo...
Induction chemotherapy for locally advanced sinonasal carcinoma: A systematic review and meta-analysis.
e18160 Background: Induction chemotherapy (IC) has emerged as a promising approach in the management of locally advanced sinonasal carcinoma. Recent studi...
Novel liquid biopsy method for detecting androgen receptor splice variant 7 in circulating tumor cells of mCRPC.
e14542 Background: Androgen receptor splice variant 7 (AR-V7) is constitutively activated isoform of AR and has been associated with the resistance toward...
Combining abemaciclib, temozolomide, and radiation in DIPG PDOX models: Insights from single-cell RNA-seq on cellular subtypes and genes critical for responsiveness and resistance.
2073 Background: Diffuse intrinsic pontine glioma (DIPG) is a highly aggressive pediatric brain tumor, with two-year survival less than 10%. Radiation the...
Tumor flare reactions secondary to T-cell engaging immunotherapies: A study from the French REISAMIC registry.
2645 Background: Tumour flare reactions (TFR) were recently reported in patients receiving T-cell engagers (TCE) and require further investigations. This...
Neurocognitive outcomes following 30.6-Gy whole-ventricular radiotherapy with 54-Gy total dose focal tumor bed boost for CNS non-germinomatous germ cell tumors: A Children’s Oncology Group study (ACNS1123).
10036 Background: COG ACNS1123 stratum 1 was a prospective, phase II trial treating children with localized non-germinomatous germ cell tumors of the brai...
Enhancing radiotherapy planning skills through structured deliberate practice and artificial intelligence integration: A pilot study.
9019 Background: In many cancer treatment protocols, radiotherapy plays a pivotal role in achieving disease control. A key component of radiotherapy plann...