Journal of Clinical Oncology
Articles in this Issue
Promoting sun safety and melanoma prevention in the community through a multi-component community-wide intervention.
e22613 Background: Although among the most preventable cancers, skin cancer is the most common cancer in the United States. The Community Preventive Servi...
Pediatric cancer in the United States: A comparison of three data sources.
e22003 Background: Pediatric cancer is rare, with 16,000 incident cases annually in the US. For every incident case of cancer in pediatrics, there are >...
Prevalence and temporal trends of prostate cancer among patients with acute cardiovascular diseases in the United States: A National Inpatient Sample analysis.
e24014 Background: Prostate cancer potentially shares cardiometabolic risk factors and an elevated risk for cardiovascular disease (CVD). However, the pre...
Combination of bispecific innate cell engager (ICE) AFM24 with atezolizumab in patients with advanced/metastatic non-small cell lung cancer (NSCLC) with <i>EGFR</i> kinase domain mutations ( <i>EGFR</i> mut): Initial results from a phase 2a study.
2610 Background: Immune checkpoint inhibitor (ICI) monotherapy has shown limited activity against advanced EGFR mut NSCLC. However...
Examining the link between p16, an aging biomarker, and a clinically meaningful functional outcome in older adults with early breast cancer.
12122 Background: Chemotherapy is thought to accelerate aging by disrupting fundamental processes of aging such as cellular senescence. Senescence is a st...
Isatuximab, carfilzomib, lenalidomide, and dexamethasone (Isa-KRd) for high-risk (HR) newly diagnosed multiple myeloma (NDMM): First-time report of the full cohort of transplant-eligible (TE) patients in the GMMG-CONCEPT trial.
7509 Background: Patients (pts) with HR NDMM have shown impaired survival outcomes even in the era of modern combination therapies. Establishing Isa-KRd i...
Serum and tumor immune cell distribution as predictor of response to immune checkpoint blockade in solid tumors.
e16029 Background: Immune Checkpoint Blockade (ICB) is established in many solid cancers often lacking robust biomarkers for response stratification. We e...
Tumor targeting chlorin e6 heptamethine cyanine conjugates: Theranostic agent for cancer imaging and photodynamic therapy.
e15132 Background: Certain heptamethine cyanine dye derivatives like MHI-148 (1a) and IR-783 exhibit strong affinity for cancer cells. These dyes selectiv...
Differences in age of diagnosis and survival period for individuals of Asian Indian/Pakistani origin and American Indian/Alaskan natives with multiple myeloma using Surveillance, Epidemiology, and End Results database from National Cancer Institute.
e19551 Background: Multiple Myeloma (MM) is one of the common hematological malignancies affecting the plasma clonal cell proliferation in the elderly pop...
Clinical outcomes and predictors of response to PD-(L)1 blockade in patients with oncogene-driver negative NSCLC who have never smoked.
8563 Background: Non-small cell lung cancer (NSCLC) in patients (pts) who have never smoked is associated with poor response to immune checkpoint inhibito...
A quality improvement initiative to improve fertility counseling and referral procedures for cancer patients at a university cancer center.
e23210 Background: Fertility counseling is crucial in cancer care as treatments can impair fertility, causing emotional distress and reducing quality of l...
Predictive effectiveness of circulating tumor DNA in recurrent early-stage non-small cell lung cancer: An updated meta-analysis.
e15025 Background: Circulating tumor DNA (ctDNA)-based minimal residual disease (MRD) detection has been integrated into the perioperative management of e...
A phase II study of lenvatinib plus everolimus in advanced extra-pancreatic neuroendocrine tumors (epNETs): Updated results and real-world comparison.
4145 Background: Advanced epNETs are rare malignancies with limited treatment options beyond somatostatin analogs, peptide receptor radionuclide therapy,...
Association of gut microbiota with therapy efficacy and prognosis in biliary tract cancer.
4111 Background: Biliary tract cancers (BTC) are rising in incidence and have poor prognosis. Microbial exposure via gut–liver axis may contribute to thei...
Biomarker changes and its prognostic significance after chemotherapy in patients with de novo metastatic breast cancer: A retrospective cohort study.
e13160 Background: It is unclear whether the expression of biomarkers such as estrogen receptor (ER), progesterone receptor (PR), human epidermal growth f...
Genomic landscape and clinical characteristics of patients (pts) with neuroendocrine prostate cancer (NEPC) with or without aggressive variant prostate cancer characterized by molecular signature (AVPC-MS).
5087 Background: NEPC is a rare, aggressive subtype that can arise de novo or after treatment with androgen receptor inhibitors. R...
Temporal and regional mortality trends in patients with hypertension and hepatobiliary cancer in the United States from 1999 to 2020.
e16310 Background: Hepatobiliary cancers (HBC) represent a diverse group of malignancies, contributing to approximately 13% of global cancer-related morta...
Outcomes with KRAS G12C inhibitors in metastatic non-small cell cancer: A systematic review and meta-analysis.
e20647 Background: KRAS G12C inhibitors have been approved for treating metastatic non-small lung cell carcinoma (mNSCLC) in patients who have received at...
Global burden of prostate cancer in 38 OECD countries and its trend from 1990-2021: An Insight from the Global Burden of Disease study 2021.
e17005 Background: Prostate cancer (PC) remains a significant public health challenge across Organization for Economic Cooperation and Development (OECD)...
Standard versus extended pelvic lymphadenectomy in patients with bladder cancer: A systematic review and meta-analysis.
e16609 Background: Pelvic lymph node dissection (PLND) has been a critical component of radical cystectomy in patients with bladder cancer. Radical surger...
Breaking down the 505(b)(2) drug price paradox.
e23168 Background: Expected to bring biosimilar-like savings for small-molecule drugs, 505(b)(2) drugs (drugs with the same active ingredient, but differi...
TROP2 expression in the gastroenteropancreatic neuroendocrine tumors: An analysis of 179 patients.
4148 Background: Trophoblast cell-surface antigen 2 (TROP2) is a transmembrane glycoprotein that exhibits overexpression i...
ELCIN: Elacestrant in women and men with CDK4/6 inhibitor (CDK4/6i)-naïve estrogen receptor-positive (ER+), HER2-negative (HER2-) metastatic breast cancer (mBC)—An open-label multicenter phase 2 study.
TPS1127 Background: Endocrine therapy (ET) plus a CDK4/6i is the mainstay treatment in first-line ER+/HER2- mBC; however, a subset of patients are unable...
Oral microbiome diversity and oral human papillomavirus-associated differences in Black vs. White individuals.
e18065 Background: Recent evidence suggests an association between oral microbiome diversity with oral HPV infection, the precursor of HPV-associated orop...
Sociodemographic disparities in survival outcomes among adolescent and young adult patients with pancreatic cancer: Insights from a SEER database analysis.
e16422 Background: Pancreatic cancer in adolescent and young adult (AYA) patients is rare and understudied. Disparities in survival outcomes based on demo...