Journal of Clinical Oncology
Articles in this Issue
Total transvaginal natural orifice endoscopic surgery (v-NOTES) for colon cancer: A prospective cohort pilot study.
e15617 Background: The abdominal incisions after laparoscopic colorectal cancer surgery remain to bother surgeons and patients due to cosmetic concerns, p...
Real-world patterns of Oncotype DX (O-Dx) testing and chemotherapy (CT) use among patients with early-stage, hormone receptor–positive (HR+) breast cancer (BC).
528 Background: O-Dx, a 21-gene assay, has transformed the management of patients with early-stage, HR+, HER2-negative (HER2-) BC by guiding personalized...
Use of Al-based models integrating serum proteomics and clinicopathologic features to predict survival outcomes in NSCLC patients undergoing immunotherapy.
e14577 Background: Responses to immune checkpoint inhibitors in patients with advanced NSCLC present a wide range of outcomes. Integrating serum proteomic...
SMET12 and toripalimab combined chemotherapy in patients with advanced non-small cell lung cancer who are treatment-naive or have developed resistance to standard therapy.
8570 Background: SMET12 is a recombinant anti-EGFR and CD3 bispecific antibody independently developed by Zhejiang Shimai Pharmaceutical. This study aims...
Outcomes and predictors of chronic graft-vs-host-disease in bone marrow transplant recipients.
e18552 Background: Chronic graft-versus-host disease (GVHD) affects approximately 20-40% of transplant recipients. It is a complication mediated by alloge...
Safety and efficacy of subcutaneous versus intravenous administration of PD (L)1 inhibitors in patients with solid tumors: A systematic review and meta-analysis.
e14590 Background: Intravenous (IV) administration of Programmed Cell Death 1/Ligand 1 (PD (L)1) inhibitors is the standard of care for the treatment of v...
Likelihood of unplanned readmission among oncology patients with a completed post-discharge follow-up encounter.
11035 Background: Literature suggests that oncology patients are more likely to be admitted from the emergency department to the hospital than patients wi...
The impact of a pilot oncology summer internship on early medical students' understanding of oncology and social determinants of health: A mixed-methods study.
e21025 Background: As cancer diagnoses rise, there is an increasing need for medical schools to engage students in oncology. Moreover, given the associati...
Using longitudinal spatial-omics to demonstrate in-situ Epstein-Barr virus reduction in responders to immunotherapy treated nasopharyngeal cancer.
6025 Background: Epstein-Barr virus (EBV) related nasopharyngeal cancer (NPC) is endemic in Southern China and Southeast Asia. Limited studies of tumor-im...
Vincristine and topotecan versus carboplatin-, etoposide-, and vincristine-based chemotherapy for ocular salvage in group D and group E intraocular retinoblastoma: A randomized, comparative trial.
10002 Background: India has the highest burden of retinoblastoma worldwide. The access to Intra-arterial chemotherapy is limited and systemic chemotherapy...
Association of inflammation with depression in pancreatic ductal adenocarcinoma.
e24059 Background: Pancreatic ductal adenocarcinoma (PDAC) exhibits the highest rates of depression, cachexia, and inflammation among cancers. Systemic in...
Regional and demographic trends in mortality from breast cancer and respiratory diseases in United States from 1999-2019: A retrospective analysis.
e13779 Background: Breast cancer and respiratory diseases are significant contributors to global morbidity and mortality, particularly in vulnerable popul...
NG11-2 phase-Ib trial to prevent/reduce severe oral mucositis induced by radiotherapy.
12121 Background: Radiation-induced oral mucositis (RIOM) affects up to 80% of people undergoing treatment for head and neck cancer (HNC), reaching nearly...
Correlation of elevated CA19-9 and cancer associated macrophages in blood with outcomes in pancreatic cancer patients over 5 years.
e16464 Background: Pancreatic cancer (PC) is a highly aggressive cancer accounting for ~7% of all cancer related deaths in the United States. In PC, Carbo...
Efficacy and safety of immune checkpoint inhibitors in patients with unresectable metastatic colon cancer with microsatellite instability high or mismatch repair deficiency: A systematic review and meta-analysis.
e15543 Background: Metastatic colon cancer (mCRC) characterized by microsatellite instability-high (MSI-H) or mismatch repair-deficient (dMMR) status in s...
Predicting nodal burden after neoadjuvant chemotherapy (NAC) with circulating tumor (ct)DNA for surgical planning: Results from the I-SPY2 trial.
504 Background: Axillary surgery in breast cancer is used for staging and therapeutic purposes, but axillary lymph node dissection (ALND) confers high ris...
Effect of external beam radiotherapy on hepatic parenchymal resection rate.
e16315 Background: The hepatic parenchymal resection rate (HPRR), defined as the percentage of tumor-bearing liver volume relative to total liver volume,...
A phase I/II study evaluating the safety and efficacy of ivermectin in combination with balstilimab in patients with metastatic triple negative breast cancer.
e13146 Background: Despite recent FDA approval of immune checkpoint inhibitor (ICI) and antibody-drug conjugates (ADCs), therapeutic options for metastati...
Clinical characteristics and acute side effects of salvage radiotherapy in biochemical recurrence of prostate cancer: A retrospective cohort study.
e17004 Background: Biochemical recurrence (BCR) following radical prostatectomy poses a significant challenge in the management of prostate cancer. Salvag...
Prognostic factors in thyroid cancer patients with brain metastases: A systematic review and individual patient data meta-analysis.
e14004 Background: Brain metastases (BM) from thyroid cancer (TC) are rare but signify an advanced stage of the disease with poor survival outcomes. This...
Therapeutic decisions and outcome of patients with stage I testicular germ cell tumor: Single-centre experience.
5029 Background: Testis cancer (TC) is the most common solid neoplasm affecting men aged 15 to 40, with most of diagnosis occurring at stage I. Despite ex...
Unveiling demographic and socioeconomic patterns in hidradenocarcinoma: A retrospective National Cancer Database study.
e21580 Background: Hidradenocarcinoma is a rare and malignant tumor arising from the eccrine or apocrine sweat glands. Hidradenocarcinoma has the potentia...
SEQUOIA 5-year follow-up in arm C: Frontline zanubrutinib monotherapy in patients with del(17p) and treatment-naive chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL).
7011 Background: Zanubrutinib (zanu) is a next-generation Bruton tyrosine kinase inhibitor that is approved for 5 indications, including CLL/SLL. Initial...
Diagnostic and prognostic applications of blood cadherin-17 (CA17) and CA19.9 on pancreatic cancer.
e16459 Background: The asymptomatic nature of pancreatic cancer (PC) poses significant challenges for effective initial evaluation of suspected cases. Con...
Single-institution experience using bevacizumab for <i>IDH1/2</i> -mutant gliomas.
e14031 Background: Bevacizumab (Bev), a monoclonal antibody that inhibits vascular endothelial growth factor, was fully FDA-approved in 2017 for use in re...