Journal of Clinical Oncology
Articles in this Issue
A phase 2/3 study of bicycle toxin conjugate zelenectide pevedotin (BT8009) targeting nectin-4 in patients with locally advanced or metastatic urothelial cancer (la/mUC; Duravelo-2).
TPS4619 Background: Zelenectide pevedotin (zele; BT8009) is a Bicycle Toxin Conjugate (BTC), comprising a highly selective bicyclic peptide targeting Nect...
Long-term survival and treatment efficacy in dMMR/MSI-H rectal cancer: A real-world cohort from seven large medical college–affiliated hospitals.
3601 Background: Neoadjuvant immunotherapy provides considerable advantages for patients with dMMR/MSI-H rectal cancer. However, treatment strategies in r...
Dissecting two decades of thyroid carcinoma survival: Impact of gender, ethnicity, and income disparities.
e18162 Background: Thyroid carcinoma is the most common endocrine malignancy, originating from follicular or parafollicular cells of the thyroid gland. It...
Molecular and clonal evolution of primary lesions vs brain metastasis of EGFR-mutated NSCLC: A retrospective cohort study.
e20552 Background: Clonality is an intrinsic phenomenon of disease evolution, with specific clones conferring increased aggressiveness and apparent tropis...
Atezolizumab and stereotactic body radiation in metastatic, recurrent, or persistent cervical cancer: Results from a phase II multi-institutional study.
5536 Background: Pembrolizumab is approved for PD-L1+ but not PD-L1 negative metastatic, recurrent, or persistent cervical cancer. Response rates to singl...
A phase II study of encorafenib and cetuximab (EC) beyond progression in combination with FOLFIRI in <i>BRAF</i> V600E-mutated metastatic colorectal cancer (mCRC).
TPS3642 Background: BRAF V600E mutation occurs in approximately 10% of metastatic colorectal cancers (...
Rationale and study design of the KOV-HIPEC-02R (RECOVER): A randomized, multicenter, open-label phase III trial of cytoreductive surgery and hyperthermic intraperitoneal chemotherapy in platinum-resistant recurrent ovarian cancer.
TPS5628 Background: Hyperthermic intraperitoneal chemotherapy (HIPEC) administered during interval cytoreductive surgery following neoadjuvant chemotherap...
DREAMseq: A phase III trial of treatment sequences in BRAFV600-mutant (m) metastatic melanoma (MM)—Final clinical results.
9506 Background: The DREAMseq trial compared efficacy and toxicity of the sequence of nivolumab/ipilimumab (N/I) followed by dabrafenib/trametinib (D/T) t...
Molecular and prognostic convergence of HR+/HER2– metastatic breast cancer (MBC) to a TNBC-like profile: Insights from circulating tumor DNA (ctDNA)-based genomic analysis across treatment lines.
1072 Background: While the transition to a triple negative (TNBC)-like profile represents a recognized mechanism of treatment resistance for hormone recep...
CD5-deleted chimeric antigen receptor cells (Senza5 CART5) to enhance immunotherapy against T-cell non-Hodgkin lymphoma: A first-in-human phase I clinical trial (NCT06420089).
TPS7087 Background: Autologous CART options for patients with relapsed or refractory (R/R) T-cell lymphomas (TCL) have faced challenges such as T-cell fra...
Phase 1a dose-escalation study of RS-0139: A novel tumor-targeted nanomedicine for advanced solid tumors.
e15006 Background: RS-0139 is a tumor-targeted prodrug designed to enhance the therapeutic index of docetaxel (DTX) by selectively delivering the active a...
Efficacy and safety of larotrectinib in patients with TRK fusion thyroid carcinoma: An updated analysis.
6094 Background: NTRK gene fusions are oncogenic drivers in various tumor types, including thyroid carcinoma (TC). Larotrectinib (laro) is the...
Implementation of a fellow-led tumor board to enhance learning and support in fellow continuity clinic.
9000 Background: Hematology/oncology fellows in our program manage diverse and complex cases in continuity clinic (CC), including uncommon malignancies an...
The STAMPEDE2 trial: A site survey of current patterns of care, access to imaging, and treatment of metastatic prostrate cancer in Nigeria.
e23059 Background: The STAMPEDE2 trial builds on the foundational STAMPEDE trial, which introduced innovative multi-arm treatment protocols for metastatic...
Concordance between a multidisciplinary tumor board and ChatGPT 4.0 in the management of genitourinary tumors: A real-world analysis.
e23256 Background: Artificial intelligence (AI) is emerging as a valuable tool to support clinical decisions in oncology. Nevertheless, its practical impl...
Histologic comparison of the area of tumor bed after vacuum-assisted biopsy (VAB) or standard breast surgery in patients with early breast cancer after neoadjuvant systemic therapy (NST).
e12573 Background: The main goal of surgical intervention after achieving complete clinical response is to confirm it pathmorphologically. VAB of the tumo...
Comprehensive genomic profiling of Black and non-Hispanic White (NHW) men with prostate cancer (PCa).
5022 Background: Racial disparities are evident in PCa, with Black men experiencing a higher incidence and worse survival compared to NHW patients (pts)....
A randomized, phase 2/3 clinical trial investigating RP2 plus nivolumab vs ipilimumab plus nivolumab in immune checkpoint inhibitor-naïve patients with metastatic uveal melanoma.
TPS9597 Background: Uveal melanoma (UM) is the most common primary intraocular malignancy, accounting for nearly 90% of ocular melanomas and up to 5% of m...
Demographic and regional trends and disparities in leukemia mortality in the United States (1999–2022): A comparative analysis of underlying and contributing cause models of death.
e18517 Background: Leukemia, a hematological malignancy, ranks as the sixth leading cause of cancer-related deaths in males and seventh in females in the...
Practical geriatric assessment (PGA) implementation strategies and correlative evaluations (PACE-70): A hybrid implementation-effectiveness study in 3 community practices.
TPS1661 Background: The use of a geriatric assessment to inform oncologic care for older persons with cancer is an evidence-based practice that improves p...
The prognostic and predictive value of the immunological gene signatures interferon gamma and TIDE for patients with liver metastases from uveal melanoma treated with isolated hepatic perfusion.
e21596 Background: Uveal melanoma (UM) is a rare cancer that often metastasizes to the liver. The SCANDIUM trial investigated the efficacy of isolated hep...
Clinicopathological features and prognostic implications of HER2-low in early-stage male breast cancer: A retrospective analysis.
e12518 Background: The clinicopathological and prognostic features of HER2-low female breast cancer (BC) have been widely studied. Current knowledge sugge...
Distribution of non-metastatic and metastatic disease in incidentally detected and screening-detected lung cancers.
e20088 Background: Early detection of lung cancer is known to enhance outcomes by enabling treatment at earlier stages. This study explores whether the st...
Interim open-label phase 1 results of misetionamide (GP-2250): A small molecule antineoplastic targeting three major transcription factors.
4177 Background: GP-2250 is a novel antineoplastic agent demonstrating effective activity on preclinical pancreatic cancer models alone or in combination...
Antibody drug conjugates treatment response score (ADC TRS) for sequencing trastuzuamb deruxtecan (T-DXd) and sacituzumab govitecan (SG) in advanced breast cancer (aBC).
1053 Background: T-DXd, targeting HER2, is approved in hormone receptor positive or negative (HR+/-) HER2-low (1-2+ by immunohistochemistry [IHC]) and HR+...