Journal of Clinical Oncology
Articles in this Issue
What is left in pMMR/MSS BRAF V600E metastatic colorectal cancer (mCRC)? Prognostic role of tumor sidedness and molecular co-mutations.
e15608 Background: BRAF V600E-mutated pMMR/MSS mCRC has poor prognosis. However, real-world outcomes are heterogeneous and...
Neoadjuvant dalpiciclib combined with letrozole and dual HER2 blockade in HR+/HER2+ breast cancer: First-stage results of the HELEN HER2 017 trial.
1054 Background: Triple-positive breast cancer (TPBC; HR+/HER2+) represents a distinct subtype with suboptimal responses t...
Relationship between immune-mediated adverse events and clinical outcomes in patients with metastatic melanoma treated with immune checkpoint inhibitors (ICIs): A retrospective real-world analysis.
11144 Background: ICIs targeting programmed cell death protein 1 (PD-1) and cytotoxic T-lymphocyte–associated protein 4 (C...
Perceptions of Medicaid coverage and care experiences among long-term survivors of childhood cancer: Qualitative interviews from the Childhood Cancer Survivor study (CCSS).
10051 Background: Childhood cancer survivors require lifelong, risk-based follow-up care. Survivors insured by Medicaid ma...
Colon cancer sidedness in relation to sepsis risk and clinical predictors: A National Inpatient Sample analysis.
e15700 Background: Colon cancer patients are at increased risk for developing sepsis during hospitalization. It is unclear...
<i>MACROD2</i> and <i>CDKN2A</i> in multiple myeloma: Insights to germline susceptibility and cytogenetic risk from long-read Nanopore sequencing.
e19566 Background: The MACROD2 gene is a chromosomal fragile site that undergoes f...
Relative benefit of perioperative chemotherapy after resection for stage III colon cancer in the 70s age range: SEER 2004–2015.
e13778 Background: The magnitude of survival benefit associated with perioperative chemotherapy after resection for stage...
Real-world patterns and outcomes of cancer-related distress assessed by the NCCN distress thermometer in community oncology practice in western India.
e13578 Background: Cancer-related distress can adversely affect treatment adherence and quality of life, yet real-world ev...
Lipid reprogramming as driver of statin-targetable vulnerability in early-onset prostate cancer.
e17147 Background: Early-onset prostate cancer (EOPC, age ≤55 years) is increasing in incidence and displays distinct clin...
Impact of facility type and surgical management on survival outcomes in colon adenocarcinoma stratified by metastatic burden.
11129 Background: Survival for colon cancer varies by facility type, yet the impact of granular metastatic burden and surg...
c-MET expression by IHC and response to cabozantinib in patients with relapsed, refractory germ-cell tumor: A single-arm phase II trial.
e17015 Background: Cabozantinib, a multi-targeted tyrosine kinase inhibitor targeting c-MET, VEGFR, and AXL, shows clinica...
Phase 1 clinical trial investigating the safety, pharmacokinetics, pharmacodynamics, and antitumor activity of AB821 in adult patients with locally advanced or metastatic melanoma and other solid tumor malignancies (NCT 07027488).
TPS2687 Background: In recent years, T-cell enhancement strategies have achieved notable survival benefits in patients wit...
Gender representation in first and senior authorship of phase III solid-tumor trials presented at the ASCO Annual Meeting, 2015-2025.
9006 Background: Authorship in clinical trials reflects access to research infrastructure, funding, and academic advanceme...
Clinical utility of PET-CT in the management of colorectal liver metastases.
e15547 Background: Patients with colorectal cancer liver metastases (CRCLM) may be considered for potentially curative liv...
Differential risk of interstitial lung disease with DXd-based versus non-DXd TROP2 antibody-drug conjugates: A systematic review and meta-analysis.
e15037 Background: TROP2 directed antibody drug conjugates (ADCs) have demonstrated efficacy across multiple solid tumors....
Non–small cell lung cancer and the obesity paradox: A retrospective cohort study using the TriNetX database.
e20544 Background: Although obesity is traditionally associated with adverse health outcomes, paradoxical survival benefit...
Phase 1 study of induction chemoimmunotherapy (ICI) with cemiplimab in combination with cisplatin and docetaxel (TPI) in locally advanced squaous cell carcinoma of the head and neck (LA SCCHN).
e18085 Background: Despite advances in therapy, overall survival for locally advanced squamous cell carcinoma of the head...
Correlation between real-world progression-free survival and time to next treatment and death in advanced ovarian cancer patients receiving non-platinum therapy in second or later lines.
e17578 Background: Advanced ovarian cancer (aOC) is typically treated with platinum-based first-line therapy, but in secon...
SHR-A1811 plus chemotherapy and BP102 as 1L therapy for HER2-expressing mCRC: Data from a phase Ib/II study.
3569 Background: HER2 expression is associated with poor prognosis in mCRC. SHR-A1811 (trastuzumab-rezetecan) is a HER2-di...
Quantitative CT lung fibrosis and immune checkpoint inhibitor–related pneumonitis in NSCLC.
e20531 Background: Interstitial lung abnormalities (ILAs) are established risk factors for immune checkpoint inhibitor–rel...
Long-term survival results of perioperative chemoimmunotherapy with DCF and avelumab in locally advanced gastro-esophageal adenocarcinoma.
4096 Background: We have shown that avelumab, an anti-PD-L1 antibody, added to perioperative modified DCF chemotherapy (aD...
Hospital designation and survival disparities in young-onset gastrointestinal cancer.
1535 Background: Early-onset gastrointestinal (GI) cancers (<50 years) are increasing in incidence. We examined the imp...
SWIVEL: A randomized phase II trial of switching medications versus guideline-directed interventions for adjuvant aromatase inhibitor side effects in breast cancer patients.
TPS12171 Background: Approximately half of breast cancer patients do not complete the standard 5-year course of adjuvant h...
Clear cell–type squamous cell carcinoma: An NCDB analysis.
e21549 Background: Clear cell–type squamous cell carcinoma (ccSCC) is a rare, aggressive histologic variant of squamous ce...
Patient characteristics and real-world utilization of darolutamide in advanced prostate cancer among a national cohort of veterans.
e23426 Background: Darolutamide (DARO) has demonstrated efficacy and a tolerable safety profile in prostate cancer (PC) cl...