Journal of Clinical Oncology
Articles in this Issue
Distinct immunogenomic features of cancers arising in solid organ transplant recipients.
10587 Background: Solid organ transplantation recipients (SOTRs) are at increased risk of cancer due to long-term immunosu...
Post-transplant outcomes stratified by induction therapy in patients with AML undergoing allogeneic transplantation.
e18572 Background: Allogeneic hematopoietic cell transplantation (allo-HCT) remains the only curative option for patients...
From pathophysiology to prognosis: An oncology curriculum for interdisciplinary palliative care specialists.
9026 Background: Integrating specialty palliative care (SPC) improves outcomes for patients with advanced cancer, yet effe...
CXCR2 expression in lung neuroendocrine neoplasms.
e20143 Background: The incidence of lung neuroendocrine neoplasms (NENs), which account for 1%-3% of all lung malignancies...
Factors associated with treatment response and survival outcomes in plasmablastic lymphoma: A retrospective study in a predominantly Hispanic population.
e19099 Background: Plasmablastic lymphoma (PBL) is a rare, aggressive NHL with historically poor outcomes and a median ove...
Healthcare utilization and end-of-life care in pancreatic cancer: A single-institution cohort study.
e23206 Background: Pancreatic cancer carries high symptom burden and frequent acute care use, yet real-world utilization a...
Clinical outcomes and cumulative cost of preventive surveillance versus treatment in Li–Fraumeni syndrome: Results from the European PREVENTABLE project.
10553 Background: Li-Fraumeni syndrome (LFS), caused by TP53 pathogenic variants,...
A randomized phase II clinical trial of a fasting-mimic diet prior to chemotherapy to evaluate the impact on toxicity and efficacy.
e12522 Background: Fasting may help reduce the toxicity of certain chemotherapy drugs but a low calorie, low protein fasti...
Phase 1A/B study of AB248, a CD8+ selective IL-2 mutein fusion protein, alone or in combination with pembrolizumab, in patients with advanced solid tumor malignancies.
2616 Background: High-dose IL-2 demonstrates modest activity in melanoma and RCC but its use is limited by severe toxicity...
A non-invasive methylation-based NGS assay for sensitive detection of pancreatic cancer.
e16452 Background: Non-invasive tools with high sensitivity to distinguish pancreatic cancer from benign pancreatic lesion...
Phase II study of bevacizumab plus trifluridine/tipiracil and irinotecan as second-line therapy for RAS wild-type metastatic colorectal cancer.
e15578 Background: Patients with RAS wild-type (RASwt) metastatic colorectal cancer (mCRC) progressing on first-line fluor...
Effects of external beam radiation therapy and androgen deprivation therapy on physical activity of men with non-metastatic prostate cancer.
e17028 Background: Physical activity (PA) has been shown to have a profound positive impact on the quality of life of peop...
Efficacy and safety of cetuximab-irinotecan rechallenge versus regorafenib in <i>RAS</i> wild-type metastatic colorectal cancer.
3537 Background: Anti-epidermal growth factor receptor (EGFR) antibodies are widely used in the treatment of RAS wild-type...
A phase 1/2a, multicenter, first-in-human, open-label clinical trial evaluating MDX2004 monotherapy in patients with advanced tumors.
TPS2686 Background: MDX2004 is a trispecific antibody–fusion protein developed as an immunotherapy for advanced cancers. I...
The weight of each node: Modeling and quantifying breast cancer lymphedema risk.
e12750 Background: Lymphedema (LE) is a common morbidity following breast cancer surgery, affecting quality of life. While...
Income inequality and cervical cancer: A comparative analysis of demographics and healthcare burden of women in the lowest and highest income quartiles.
5521 Background: Cervical cancer disproportionately affects women of lower socioeconomic status, yet comprehensive data co...
A phase 2 trial of IO102-IO103 and nivolumab-relatlimab in previously untreated, unresectable melanoma.
9519 Background: IO102-IO103 is an investigational cancer vaccine that targets both tumor and immune-suppressive cells in...
Integrating a small extracellular vesicle protein–based ovarian cancer score with O-RADS Ultrasound to improve preoperative risk stratification of adnexal masses.
5555 Background: Accurate preoperative differentiation of adnexal masses remains a major clinical challenge. Although the...
Neighborhood social vulnerability and clinical trial enrollment in colon cancer: Does age matter?
1533 Background: Colorectal cancer is now the leading cause of cancer-related death in people under 50, and young adults l...
RINGSIDE: A phase 3 randomized, placebo-controlled trial of varegacestat for treatment of progressing desmoid tumors.
11506 Background: Desmoid tumors (DT) are rare, locally aggressive tumors with few effective treatments. Varegacestat (VAR...
Racial and ethnic differences in cardiovascular disease prevention and treatment amongst breast cancer survivors.
e23331 Background: Breast cancer is the second leading cause of cancer death among women in the U.S., and heart disease re...
Endometrial cancer risk management in patients with Lynch syndrome at a tertiary community cancer center.
e22539 Background: Lynch syndrome (LS) is a genetic predisposition associated with germline alterations in the DNA mismatc...
Iparomlimab and tuvonralimab (PD-1/CTLA-4 bifunctional antibody) monotherapy or combination therapy in patients with advanced solid tumors treated.
e23358 Background: Patients with advanced solid tumors that progress after first-line treatment, particularly after PD-(L)...
Geographic clustering of renal cell carcinoma in West Virginia counties with historical perfluorooctanoic acid (PFOA) exposure.
e16525 Background: Perfluorooctanoic acid (PFOA), a persistent per- and polyfluoroalkyl substance (PFAS), has contaminated...
Gene and isoform transcriptomics to uncover distinct immune and signaling programs across sarcoma subtypes.
e23538 Background: Sarcomas are heterogeneous malignancies arising from diverse mesenchymal lineages. While transcriptomic...