Journal of Clinical Oncology
Articles in this Issue
In vivo CAR T-cell engineering in B-cell malignancies: A systematic review of emerging clinical and translational evidence.
e14512 Background: Autologous ex vivo CAR T-cell therapies have transformed outcomes in relapsed/refractory (R/R) B-cell m...
NALIRIFOX in combination with adebrelimab for advanced biliary tract cancer: A phase 2 NIOFA-01 clinical trial.
4120 Background: The NIOFA-01 trial was designed to evaluate the efficacy and safety of liposomal irinotecan combined with...
Balancing effectiveness and toxicity: Cabozantinib versus belzutifan after ICI/VEGF therapy in older adults with renal cell carcinoma.
e16533 Background: First line therapy for favorable and intermediate/poor risk mRCC is Pembrolizumab and Axitinib. Multipl...
Benefit of adjuvant therapy in high-risk GIST: A large-scale real-world analysis of 2,166 patients (DEEPSARC study).
11533 Background: Real-life data on the impact of adjuvant treatment in GIST pts are limited. Methods:...
Impact of artificial intelligence assistance on combined PD-L1 scoring on whole immunohistochemical slide image of tumors.
e16006 Background: Immune checkpoint blockade targeting PD-L1 has transformed cancer treatment, making accurate evaluation...
Using process mapping to improve clinical care for patients receiving cancer treatment in resource-limited settings.
e23249 Background: Process mapping is a low-cost, low-technology approach that can be used to understand and improve clini...
Cancer-associated bradyarrhythmias and inpatient deterioration in U.S. hospitalizations.
e23107 Background: Cardiac rhythm disturbances in oncology are most often studied in atrial fibrillation and tachyarrhythm...
Functional assessment of polymerase proofreading variants to define sensitivity to immune checkpoint blockade (ICB) pan-cancer.
2645 Background: Cancers with inactivating alterations in DNA proofreading polymerases POLE and POLD1 (POLd) are ultra-hyp...
Real-world nutritional outcomes assessed by subjective global assessment in community oncology practice in western India.
e13576 Background: Cancer-related malnutrition affects treatment tolerance & survival, yet real-world data from Wester...
Regulatory role of IRF2 in proliferation and invasion of nasopharyngeal carcinoma: Investigation into underlying mechanism.
e18052 Background: The recurrence and progression of nasopharyngeal carcinoma (NPC) are major factors contributing to unsa...
New paradigms of cancer and new language: A qualitative study exploring language around goals of cancer surgery.
12099 Background: Cancer interventions are often discussed amongst providers and presented to patients within the dichotom...
Incidence and disability burden of pancreatic cancer in the United States compared with high socio-demographic index countries: A global analysis, 1990–2023.
e16390 Background: Pancreatic cancer remains one of the most lethal malignancies worldwide, with limited improvements in l...
Post-operative neurologic outcomes in children with WNT-medulloblastoma.
e22005 Background: WNT-activated medulloblastoma (WNT-MB), the least common molecular subtype of medulloblastoma with a pu...
Discrimination and medical trust among breast cancer outpatients in an urban safety net setting.
e13726 Background: Discrimination in health care is prevalent and linked to poorer patient-reported experiences, including...
CD40 agonist mitazalimab + mFOLFIRINOX (mFFX) in patients with metastatic pancreatic ductal adenocarcinoma (mPDAC): Final efficacy analysis of the OPTIMIZE-1 study.
e16380 Background: With a 5-year overall survival (OS) rate <5%, PDAC is a major cause of cancer-related mortality. OPT...
Burden of pancreatic cancer in the Asia–Pacific region: Incidence, mortality, and modifiable risk attribution across Southeast Asia, East Asia, and Oceania (2000–2023).
e16362 Background: Pancreatic cancer has the highest mortality-to-incidence ratio among gastrointestinal malignancies, wit...
Trends and disparities in stroke mortality among gastric cancer patients in the United States, 1999–2023.
e16023 Background: Stroke is an underrecognized cause of death among patients with gastric cancer. While overall cancer mo...
Contrast-free virtual enhancement: Multi-modal deep learning synthesis of CECT from pCT and MRI.
e17533 Background: Contrast-enhanced CT (CECT) is routinely used in radiotherapy planning to improve visualization of tumo...
The SPIN Score, a simple clinical score to predict pain response following celiac plexus radiosurgery for retroperitoneal cancer pain.
4211 Background: Celiac plexus radiosurgery is a novel non-invasive palliative treatment for pancreatic cancer pain that w...
Distinct biological and immune microenvironment features of MSI-H BRAF <sup>V600E</sup> colorectal cancer: Potential for combined PD-1, BRAF, and EGFR inhibition.
e14598 Background: Immune checkpoint inhibitors (ICIs) have shown remarkable efficacy in microsatellite instability-high (...
Phase I study of BL-M14D1, a novel DLL3-directed antibody-drug conjugate (ADC), in patients with locally advanced or metastatic small-cell lung cancer (SCLC), neuroendocrine carcinoma (NEC), and other solid tumors.
3001 Background: BL-M14D1 is a novel DLL3-directed ADC with a potent topoisomerase I inhibitor Ed-04. Results for safety a...
Study on the mechanisms of alpha-linolenic acid in influencing the efficacy of immunotherapy for lung squamous cell carcinoma.
e20639 Background: Alpha Linolenic acid (ALA) has been shown to correlate with gut microbiota and plays a significant role...
A phase 2 study to assess the safety and efficacy of bomedemstat (IMG-7289) in combination with momelotinib in patients with myelofibrosis.
TPS6605 Background: Myelofibrosis (MF) is a chronic myeloproliferative neoplasm characterized by splenomegaly, cytopenias,...
The impact of different formulations and dosing intervals of goserelin on testosterone suppression in patients with prostate cancer: A real-world observational study.
e17093 Background: The purpose of androgen deprivation therapy (ADT) is to reduce and stabilise serum testosterone. Howeve...
AI-derived CD8⁺ cytotoxic T-cell immune signatures from baseline H&E images to predict immunotherapy benefit over chemotherapy in non–small cell lung cancer: Blinded validation in CheckMate-227 (CM227).
8534 Background: Immunotherapy (IO) has transformed treatment for non–small cell lung cancer (NSCLC), but not all patients...