Journal of Clinical Oncology
Articles in this Issue
Questioning the benefit of adjuvant chemotherapy in premenopausal HR+/HER2– early breast cancer: Real-world evidence from an Asian cohort.
39 Background: The benefit of adjuvant chemotherapy in premenopausal women with hormone receptor (HR)–positive, HER2-negat...
EBV DNA dynamics guide post-local-therapy ICI consolidation in stage II-III pulmonary lymphoepithelioma-like carcinoma.
274 Background: Immune checkpoint inhibitors (ICIs) improve outcomes in pulmonary lymphoepithelioma-like carcinoma (PLELC)...
Machine learning prediction of clinical tumor lysis syndrome in critically ill patients with hematologic malignancies using laboratory trajectory features: A MIMIC-IV retrospective cohort study.
263 Background: Tumor lysis syndrome (TLS) remains a life-threatening oncologic emergency in patients with hematologic mal...
An integrative multi-omics machine learning framework for precision metastasis prediction and clinical staging in non-small cell lung cancer.
11 Background: Traditional TNM staging inadequately captures the biological aggressiveness of NSCLC. While cell cycle dysr...
Circulating tumor suppressor microRNAs as minimally invasive biomarkers for early detection of colorectal cancer.
103 Background: Early diagnosis of colorectal cancer (CRC) remains a major clinical challenge contributing significantly t...
Association of a high-speed, knowledge-based AI tool at the primary care level with zero-miss triage and detection of incidental pulmonary nodules.
270 Background: In mainland China, the high accessibility and remarkably low out-of-pocket cost of chest computed tomograp...
Kaposi's Sarcoma in patients exposed to calcineurin inhibitors or systemic corticosteroids: A two-decade real-world safety assessment.
356 Background: Kaposi’s Sarcoma (KS) is a rare angioprolefrative tumor, occurring in approximately 2 per 1 millio...
A single-cell multi-omic atlas of extrahepatic cholangiocarcinoma progression with ST6GAL1-enriched preinvasive states.
176 Background: Extrahepatic cholangiocarcinoma (eCCA) is frequently diagnosed at advanced stages, limiting opportunities...
Phase 1 dose escalation of ACM-CpG, a polymersome-delivered TLR9 agonist for advanced solid tumors after prior treatment with checkpoint inhibitor.
TPS91 Background: ACM-CpG is a novel innate immune activator comprising of TLR9 agonist CpG7909 encapsulated within polyme...
Expectations and unmet needs of cancer patients seeking Ayurved Rasayana therapy: A cross-sectional study from India.
346 Background: The objective of this study was to assess the expectations and objectives of cancer patients opting for In...
Real-world efficacy and safety of first-line durvalumab combined with platinum–etoposide in extensive-stage small cell lung cancer: A single-center experience in Vietnam.
281 Background: Durvalumab combined with platinum–etoposide is the standard first-line treatment for extensive-stage small...
Genomic profiling of adolescent and young adult cancers in Asia: A scoping review.
166 Background: Adolescents and young adults (AYAs, aged 15–39 years) represent a distinct yet under-recognised cancer pop...
AI-assisted colonoscopy and detection/miss of adenomas and sessile serrated lesions: An updated systematic review and meta-analysis.
4 Background: AI-assisted colonoscopy may improve real-time lesion recognition across multiple quality indicators, includi...
Clinical characteristics and mutation status of KRAS, NRAS, and BRAF genes in stage IV colorectal cancer patients at Hanoi Medical University Hospital.
149 Background: RAS and BRAF mutations play an important role in treatment selection and prognosis in metastatic colorecta...
The impact of end-of-consolidation measurable residual disease in the era of novel pediatric leukemia therapy.
259 Background: The introduction of blinatumomab (BLINA) has improved event-free survival (EFS) and overall survival (OS)...
Tofacitinib for immune-related adverse events ≥ grade 3 induced by immune checkpoint inhibitors: A single-arm, open-label, two-stage study.
81 Background: This study evaluates the efficacy and safety of tofacitinib, a JAK inhibitor, in treating irAEs and explore...
Prediction model for recurrence and metastasis of cervical cancer after surgery using machine learning.
207 Background: To analyze the relationship between the results of routine blood tests and blood biochemistry in cervical...
A non-invasive lncRNA biomarker model for detection and metastatic risk prediction in prostate cancer.
180 Background: Early detection and precise metastatic risk stratification in prostate cancer (PCa) remain major challenge...
Effects of sodium–glucose cotransporter 2 inhibitors on mortality and heart failure hospitalization in patients with cancer and diabetes mellitus: An updated systematic review and meta-analysis.
312 Background: Cardiovascular disease and cancer frequently coexist, and anticancer therapies can worsen cardiometabolic...
Effect of sex-related non-immune cell crosstalk in the tumor microenvironment on skeletal muscle loss in colorectal cancer.
152 Background: Colorectal cancer (CRC) progression is influenced by multiple risk factors, including sex-based difference...
Early toxicity–driven dose modification and efficacy of adjuvant abemaciclib in high-risk HR+/HER2− early breast cancer: A real-world study in Chinese patients.
38 Background: Adjuvant abemaciclib plus endocrine therapy (ET) improves invasive disease-free survival (iDFS) in patients...
Structural modelling of germline FOXA1 variants identified in Asian participants with incident gastrointestinal cancers from the UK Biobank.
165 Background: Interpretation of rare germline missense variants identified through population-scale exome sequencing rem...
Effect of cancer-neurons on cytotoxic NK cell exhaustion and immunotherapy resistance in gastric cancer via spatial ECM trapping and neuropeptide signaling.
147 Background: Immunotherapy resistance remains a critical clinical challenge in gastric cancer (GC). While tumor-associa...
Efficacy and safety of first-line modified docetaxel, cisplatin, and fluorouracil (mDCF) in advanced esophageal cancer: A retrospective study from Viet Nam.
97 Background: In Viet Nam, most advanced esophageal cancer patients cannot access combined immunotherapy due to high cost...
The ELIMINATE trial: A phase II/III randomized trial evaluating omission of radiotherapy to regional lymphatics in pN0/N1 neck for oral cavity carcinomas.
TPS243 Background: Postoperative radiotherapy (PORT) improves locoregional control in oral cavity squamous cell carcinoma...