Journal of Clinical Oncology
Articles in this Issue
Real-world comparative safety and survival of alpelisib-fulvestrant versus capivasertib-fulvestrant in HR+/HER2− metastatic breast cancer: A propensity score–matched analysis.
46 Background: Alpelisib (PI3Kα inhibitor) and capivasertib (AKT inhibitor), each combined with fulvestrant, are approved...
Clinical features and long-term outcome in children and adolescents with non-Hodgkin lymphoma: A report of the Taiwan Pediatric Oncology Group study TPOG-NHL-2010.
258 Background: Children and adolescents with non-Hodgkin lymphoma (NHL) have different distributions of histologic subtyp...
Stereotactic body radiotherapy combined with chemotherapy and PD-1 inhibitor in oligometastatic nasopharyngeal carcinoma (STOMP): A prospective phase II clinical trial.
232 Background: To evaluate the efficacy and safety of stereotactic body radiation therapy (SBRT) combined with gemcitibin...
TP53–EGFR co-mutation landscape in Indian NSCLC: Decoding the genomic blueprint for targeted therapeutic decisions.
267 Background: Lung cancer, especially non-small cell lung cancer (NSCLC), exhibits significant molecular heterogeneity t...
Molecular residual disease detection for ovarian cancer using a WGS-based ctDNA assay: Initial findings from the MONSTAR-SCREEN-3.
202 Background: Ovarian cancer, including fallopian tube and primary peritoneal carcinoma, is often diagnosed at advanced...
Effects of a self-determination theory-based smoking cessation intervention plus instant messaging via instant messaging for smokers with cancer: A randomized controlled trial.
314 Background: Continued smoking after a cancer diagnosis is associated with increased all-cause mortality and reduced tr...
Efficacy of dance-based interventions on psychosocial outcomes and fatigue in breast cancer survivors: A systematic review and meta-analysis.
52 Background: Breast cancer survivors endure treatment side effects including cancer-related fatigue (CRF), sleep disturb...
Real-world insights of patterns of palliative and end-of-life care in patients with advanced cancer: LMIC single-center wake-up call.
336 Background: Early integration of palliative care (PC) is recommended in advanced cancer to improve quality of life and...
Causal machine learning–guided personalized immunochemotherapy strategies in intrahepatic cholangiocarcinoma (CMICC).
1 Background: Immunochemotherapy (IO-chemo) has become the first-line standard care for patients with advanced int...
Beating the clock: Immunotherapy timing, early immune modulation, and clinical outcomes in hepatocellular carcinoma.
322 Background: Circadian regulation of immune function is closely linked to hepatic physiology and may influence response...
Diagnostic performance of the IOTA SR xCA-125 model in predicting ovarian malignancy in women undergoing surgery for adnexal masses.
205 Background: The preoperative differentiation of adnexal masses is crucial for appropriate patient management. While ul...
Real-world comparison of cabozantinib versus regorafenib as second-line therapy for advanced hepatocellular carcinoma after first-line immune checkpoint inhibitors: A propensity score–matched analysis.
132 Background: Immune checkpoint inhibitor (ICI)–based regimens are the standard first-line therapy for advanced hepatoce...
Association of oncology education through virtual engagement with gender and geographic disparities: A global longitudinal analysis (2022–2025).
325 Background: Persistent gender disparities in academic visibility and leadership continue to limit equity in global onc...
Upfront 69-gene next-generation sequencing versus reflex PCR in BCR::ABL1-negative myeloproliferative neoplasms: Diagnostic yield, prognostic impact, and cost analysis in an Indian cohort.
163 Background: Sequential PCR testing for JAK2, CALR, and MPL mutations remains standard in MPN evaluation but misses non...
Divergence between expected and observed national cancer mortality after the COVID-19 pandemic: A population-based analysis.
303 Background: The COVID-19 pandemic disrupted cancer screening, diagnosis, and treatment, yet its long-term impact on ca...
Association of higher thermal dose with improved 5-year recurrence-free survival after locoregional hyperthermia combined with intravesical chemotherapy for non-muscle-invasive bladder cancer.
190 Background: To investigate the continuous thermal dose (TD)-effect relationship for estimating the probability of 5-ye...
SGLT-2 inhibitors and heart failure outcomes in cancer patients and survivors: An updated systematic review and meta-analysis.
311 Background: Sodium–glucose cotransporter-2 inhibitors (SGLT-2i) reduce heart failure risk in the general population, b...
Axillary lymph node metastasis status and associated factors in patients with breast cancer undergoing radical surgery.
63 Background: Breast cancer remains one of the most frequently diagnosed malignancies and a leading cause of cancer-relat...
Bayesian multimodal modeling with explainable artificial intelligence to predict response to GBE1-targeted metabolic therapy in colorectal cancer.
9 Background: Colorectal cancer (CRC) remains a leading cause of cancer-related mortality worldwide, with therapeutic resi...
B7H3/IL13Rα2 bispecific armored CAR-T for recurrent/refractory glioblastoma: Safety, efficacy, and immune dynamics.
69 Background: Recurrent/refractory glioblastoma (GBM) has an extremely poor prognosis with limited therapies. CAR...
Biomarker-independent real-world effectiveness and safety of toripalimab in advanced esophageal squamous cell carcinoma: A multicentre Indian experience.
131 Background: Toripalimab has demonstrated survival benefit in advanced esophageal squamous cell carcinoma (ESCC) in ran...
Real-world treatment patterns and survival outcomes in acinic cell carcinoma of the breast: A National Cancer Database study.
41 Background: Acinic cell carcinoma (ACC) of the breast is a rare subtype characterized by serous acinar differentiation...
Addressing radiologist inter-reader variability in gastric cancer T staging: A prospective study using the dual-module AI model, TRACE.
102 Background: Gastric cancer, a leading global malignancy with high incidence and mortality, poses a significant public...
Targeting human neuropeptide Y1 receptor (NPY1R) using a monoclonal antibody that targets an extracellular epitope.
65 Background: Neuropeptide Y1 Receptor (NPY1R), a G protein-coupled receptor, is essential for regulating appetite, energ...
Molecular classification of biliary tract cancer by RNA clustering analysis and its clinicopathological characteristics.
143 Background: Biliary tract cancer (BTC) is a rare malignancy but occurs more frequently in Asian populations, where the...