Journal of Clinical Oncology
Articles in this Issue
Blinded <sup>18</sup> FDG PET-CT re-read versus EBUS-TBNA in stage III <sub>A-C</sub> NSCLC: A mediastinal staging concordance study.
280 Background: 18 FDG PET-CT is standard for mediastinal staging of NSCLC, but its specificity is low...
An oral anlotinib-capecitabine regimen plus penpulimab as first-line therapy for recurrent/metastatic nasopharyngeal carcinoma (R/M NPC): A multicenter, single-arm, phase 2 clinical trial.
227 Background: Patients with NPC who progress after radical therapy often have poor prognosis and limited tolerance. Addi...
A study of quality of life and unmet needs in young adult cancer.
320 Background: The global rise in cancer among young adults (AYAs) has shifted the focus of oncology from acute treatment...
Impact of smoking status on the efficacy of first-line immune checkpoint inhibitors in Asian patients with advanced non-small cell lung cancer: A meta-analysis.
273 Background: Smoking is associated with higher tumor mutational burden and improved responsiveness to immune checkpoint...
The impact of vertebral body irradiation techniques on dose distribution to cardiac substructure during craniospinal irradiation for pediatric medulloblastoma: A detailed dosimetric study.
72 Background: With improved long-term survival in pediatric medulloblastoma, radiotherapy-related cardiac toxicity—partic...
Clinically actionable cancer and non-cancer risk genes identified by whole genome sequencing (WGS) in early-onset tumours (EOT).
170 Background: The global incidence of EOT (≤40 years) is increasing, with no clear explanation. The short interval betwe...
Comparative efficacy and safety of sacituzumab govitecan versus chemotherapy in metastatic breast cancer: An updated meta-analysis and systematic review.
30 Background: Sacituzumab Govitecan (SG) is a Trop-2–directed antibody–drug conjugate with demonstrated survival benefit...
Effect of the FGF1-B promoter on spontaneous beta-cell tumorigenesis in F1B-Tag mice: A robust translational model for insulinoma and metabolic crosstalk.
153 Background: Fibroblast growth factor 1 (FGF1) is a key regulator of glucose homeostasis and β-cell physiology. The F1B...
Clinical significance of germline <i>BRCA</i> pathogenic variants undetectable by comprehensive genomic profiling.
161 Background: BRACAnaylsis in Japan is widely used as a companion diagnostic for PARP inhibitors in multiple can...
Impact of SPECT/CT lymphoscintigraphy-based radiotherapy planning for reducing incidental dose to arm draining lymph nodal region vs standard planning on lymphedema incidence in early breast cancer patients post BCS: A double blind randomized controlled trial.
TPS67 Background: Breast cancer-related lymphedema (BCRL) affects approximately 20-25% of patients after breast-conserving...
Inflammatory biomarker-based prognostic model for immunotherapy outcomes in patients with recurrent or metastatic cervical cancer.
210 Background: Conventional predictive biomarkers, including programmed death ligand-1 (PD-L1) expression and tumor mutat...
Synergistic oncogenesis in human cholangiocytes: IDH1 mutation and the biliary microenvironment to drive early transformation and a targetable metabolic dependency in patient-derived organoids.
308 Background: Cholangiocarcinoma (CCA) is a lethal malignancy with limited understanding of its early developmental mech...
Real-world outcomes and prognostic role of neutrophil-to-lymphocyte ratio (NLR) in patients with advanced urothelial carcinoma treated with enfortumab vedotin plus pembrolizumab (EVP).
187 Background: EVP has demonstrated a significant survival benefit in advanced urothelial carcinoma (aUC) in clinical tri...
Automation of OncoKB annotation to enhance efficiency and consistency of molecular tumor board workflows.
26 Background: Molecular Tumor Boards (MTBs) play a critical role in translating next-generation sequencing (NGS) results...
Nodal status–guided postoperative radiotherapy after neoadjuvant chemoimmunotherapy for locally advanced esophageal squamous cell carcinoma: A multicenter cohort study.
112 Background: In locally advanced esophageal squamous cell carcinoma (ESCC) treated with neoadjuvant chemoimmunotherapy...
Potential overtreatment in MRI-defined low-risk locally advanced rectal cancer in the era of neoadjuvant therapy: An international cohort study.
118 Background: Multimodal neoadjuvant therapy, including chemoradiotherapy (CRT) and total neoadjuvant therapy, is the st...
Circadian rhythm of mortality among hospitalized cancer patients: A retrospective study.
340 Background: Circadian rhythms are intrinsic 24-hour biological cycles that regulate numerous physiological processes....
Spatial multi-omics analyses to reveal KRT5 <sup>+</sup> tumor cell orchestration of an immune-excluded microenvironment in thymic carcinoma.
298 Background: Thymic carcinoma is a rare and aggressive malignancy with limited therapeutic strategies and poor clinical...
A comparative analysis of frontier large language model (LLM) performance on standardized knowledge assessments and real world scenarios in genitourinary (GU) malignancies.
21 Background: Large language models (LLMs) are becoming an increasing source of medical information for both patients and...
Endothelial glycocalyx disruption to promote colorectal carcinogenesis and recurrence through formation of TLS-deficient immune microenvironment.
148 Background: The endothelial glycocalyx is a glycan-rich layer covering vascular endothelial cells and plays an essenti...
Comparison of double lung versus single lung ventilation in prone thoracoscopic esophagectomy for esophageal cancer: A multicenter cohort study.
355 Background: Single lung ventilation (SLV) is conventionally used during thoracoscopic esophagectomy for esophageal can...
Functional outcomes and quality of life after partial glossectomy for tongue carcinoma: A prospective observational study.
237 Background: Tongue resection for carcinoma significantly impacts essential functions such as speech, swallowing, and t...
Patient, caregiver and provider perspectives on cancer treatment adherence in Singapore: A qualitative study.
332 Background: Breast and colorectal cancers remain among the most prevalent in Singapore. Adherence to prescribed therap...
Treatment outcomes with first-line EGFR tyrosine kinase inhibitors in Vietnamese metastatic NSCLC patients harboring compound EGFR mutations.
288 Background: Compound EGFR mutations represent a heterogeneous group of genetic alterations with inferior clinical outc...
A ferroptosis-suppressive tumor state to drive chemoradiotherapy resistance and define a therapeutic vulnerability in muscle-invasive bladder cancer.
195 Background: Bladder-preserving chemoradiotherapy (CRT) is a curative alternative to radical cystectomy for muscle-inva...