Journal of Clinical Oncology
Articles in this Issue
MC220404 coordinated nivolumab and intraperitoneal IL-2 for gastric cancer with peritoneal metastasis (CONTROL) phase 1b pilot study.
TPS160 Background: Up to 50% of patients with gastric cancer (GC) may develop peritoneal metastasis (PM) that is associate...
AI-driven mortality analysis of three major neoplasms in Mexico.
13 Background: Mexico faces a growing cancer burden with limited comparative mortality data across major cancer types. We...
Development and validation of a prognostic model to independently predict cervical cancer recurrence using the immunophenotyping profiles in peripheral blood.
208 Background: The prognostic value of peripheral blood immunophenotyping for cervical cancer (CC) recurrence remains unc...
Real-world outcomes of first-line palliative treatments in advanced biliary tract cancer: A single-center experience from Thailand.
119 Background: Biliary tract cancer (BTC) represents a significant health issue in Thailand, with many patients presentin...
Development and temporal validation of a machine learning–based cancer-specific early warning score for predicting clinical deterioration in oncology ICU patients.
24 Background: Cancer patients admitted to the intensive care unit (ICU) are at high risk of clinical deterioration, yet c...
Impact of second-opinion pathology review process on diagnostic accuracy in sarcoma: Experience from the NTUH Center of Excellence for Sarcoma.
328 Background: Sarcoma is a rare and heterogeneous group of malignancies requiring accurate histopathological diagnosis t...
VEGF suppression via exon 2 splice-switching Vivo-Morpholino antisense oligo to inhibit tumor growth in a mouse subcutaneous model.
87 Background: VEGF-A is a central driver of tumor angiogenesis and is expressed as multiple pro-angiogenic splice isoform...
Active bone marrow–sparing IMRT guided by SPECT/CT functional imaging to reduce hematologic toxicity in pediatric pelvic/craniospinal irradiation: A randomized controlled trial.
75 Background: Pediatric patients receiving pelvic radiotherapy or craniospinal irradiation (CSI) are at high risk for sev...
Glucagon-like peptide-1 receptor agonists and risk of pancreatic cancer in high-risk individuals: A multicenter real-world analysis.
126 Background: Individuals with benign pancreatic neoplasms, such as intraductal papillary mucinous neoplasms, and those...
A GAN-based multimodal framework for preoperative response prediction in HER2-negative locally advanced gastric cancer treated with neoadjuvant chemoimmunotherapy.
111 Background: Gastric cancer is a leading global cause of cancer-related death, with approximately 77% of patients in Ch...
Autoimmune cytopenias associated with immune checkpoint inhibitors: A disproportionality analysis of FAERS.
83 Background: Immune checkpoint inhibitors (ICIs) enhance antitumor immunity but may disrupt peripheral tolerance, leadin...
Comparative PK/PD and efficacy data of liposomal doxorubicin and EXODS (bio-engineered exosomes loaded with doxorubicin) in metastatic triple-negative breast cancer.
57 Background: Adverse reactions like vomiting, fatigue, oral sores, severe tissue ulceration, and necrosis are common in...
Comparative effectiveness of first-line ribociclib plus aromatase inhibitor versus palbociclib plus aromatase inhibitor in HR+/HER2− metastatic breast cancer: A global real-world evidence study.
45 Background: CDK4/6 inhibitors combined with aromatase inhibitors (AIs) are the standard first-line therapy for HR+/HER2...
The intersection between frailty and unmet health-related social needs: Establishing the complex frailty paradigm.
96 Background: Older adults diagnosed with cancer (OAC) experience unique challenges that are often complicated by frailty...
Automated cancer data extraction using large language models: A scalable workflow for clinical documentation processing.
15 Background: Accurate and timely capture of key diagnosis variables including ICD-10-AM codes, histology, laterality and...
BC008-1A (PD-1/TIGIT bispecific antibody) in recurrent CNS WHO grade 4 glioma: Results from a randomized phase I study.
71 Background: Dual blockade of PD-1 and TIGIT may overcome T-cell exhaustion in glioma. BC008-1A is a humanized PD-1/TIGI...
Ultra-specific high-multiplex PCR liquid biopsy assays to enable high-frequency treatment and disease monitoring in urothelial malignancies.
186 Background: In urothelial cancer, several high-impact decisions are made with limited real-time molecular evidence of...
Long-term survival analysis of TNT: A phase II study of neoadjuvant toripalimab plus nimotuzumab combined with taxol-based chemotherapy in locally advanced penile squamous cell carcinoma.
177 Background: Locally advanced penile squamous cell carcinoma (La-PSCC) is an aggressive malignancy, and the pre...
Diagnostic accuracy of sentinel lymph node biopsy after neoadjuvant chemotherapy in breast cancer patients: A single-institutional experience.
47 Background: Sentinel lymph node biopsy (SLNB) after neoadjuvant chemotherapy (NACT) is a critical tool for axillary sta...
Effectiveness and safety of traditional Chinese medicine external wash combined with local cooling in preventing UTD1-induced peripheral neuropathy in breast cancer patients: A single-arm, phase II preliminary study.
50 Background: Chemotherapy-induced peripheral neuropathy (CIPN) is a prevalent and debilitating toxicity associated with...
Lactate metabolic reprogramming based on LOX/LDHi-Cu NP to enhance copper death in hepatocellular carcinoma cells.
297 Background: Cuproptosis—copper-triggered mitochondrial proteotoxicity—has emerged as a promising anti-HCC modality, ye...
Real-time breath volatile organic compound analysis to detect newly diagnosed lung cancer.
268 Background: Non-small cell lung cancer (NSCLC) is highly lethal as most cases are late stage at diagnosis. Screening e...
Adebrelimab plus TACE and/or HAIC for primary liver cancer: A retrospective study.
296 Background: This retrospective analysis reports on the use of adebrelimab—a novel PD-L1 inhibitor—in combination with...
Performance of the hybrid tumor-informed and tumor-agnostic ctDNA testing to predict breast cancer recurrence and progression: A real-world study in Southeast Asia.
42 Background: ctDNA is a novel biomarker to monitor treatment response and predict cancer recurrence. Tumor-informed ctDN...
Automated tumor content analysis from whole slide images using deep learning models for NGS quality control in precision oncology.
23 Background: Accurate tumor cell abundance (TCA) estimation is critical for ensuring sample adequacy prior to next-gener...