Journal of Clinical Oncology
Articles in this Issue
Expanding global access to oncology trials: mCODE-aligned AI for inclusive patient matching across literacy and resource settings.
18 Background: Clinical trial enrollment remains a global bottleneck in oncology. Despite therapeutic advances, only a min...
Comparative study of efficacy, toxicity, and tumor regression of nano-docetaxel+platinum+5FU vs +capecitabine in LA-HNSCC.
225 Background: Locally advanced head and neck squamous cell carcinoma (LA-HNSCC) poses challenges due to aggressive disea...
Innate immune cross-talk of glioblastoma pathophysiology: Understanding NLRP3 and NLRP12.
242 Background: Glioblastoma (GBM), a grade IV astrocytoma, is a highly aggressive malignant brain tumor with a median sur...
Barriers and facilitators of shared decision-making for pregnancy after breast cancer: A qualitative study of patients and healthcare professionals.
35 Background: As survival rates for young women with breast cancer (BC) improve, pregnancy after treatment has become an...
Family-based cascade screening in hereditary breast and ovarian cancer: Identification of asymptomatic carriers and a 15-year window for risk reduction.
168 Background: The integration of genetic screening into routine care for breast and ovarian cancers (BC and OC) has tran...
Divergent long-term burden trajectories and mortality drivers of female-specific cancers in the United States.
203 Background: Female-specific cancers contribute substantially to the cancer burden among women in the United States, ye...
Prognostic role of mismatch repair status in stage II colon cancer at Ho Chi Minh City Oncology Hospital.
146 Background: Colon cancer is among the leading causes of cancer incidence and mortality in Vietnam according to GLOBOCA...
Targeted and immunotherapy strategies in biliary tract cancer: A Bayesian network meta-analysis comparing efficacy and safety.
141 Background: Biliary tract cancer is an aggressive malignancy with limited treatment options and poor prognosis. Advanc...
Germline landscape of pancreatic cancer in Singapore and dual architecture of DNA repair and pancreatitis-associated gene variants: Implications for population-tailored testing.
162 Background: Germline pathogenic/likely pathogenic (P/LP) variants occur in up to 10% of pancreatic cancer (PC) patient...
Cancer mortality rates by educational attainment among U.S. adults aged 25–64 years: A population-based analysis (2021–2023).
348 Background: Educational attainment is a key social determinant of health that may influence cancer outcomes through di...
Real-world comparison of carboplatin–pemetrexed–bevacizumab versus chemo-immunotherapy in EGFR-mutated lung cancer.
285 Background: The optimal treatment strategy following resistance to epidermal growth factor receptor–tyrosine kinase in...
Acute skin toxicity comparison of adjuvant two-weekly accelerated hypofractionated versus three-weekly moderately hypofractionated radiotherapy in breast cancer: A phase 2, open label, randomized control trial.
TPS68 Background: Moderately hypo-fractionated radiotherapy (40 Gy/15 fractions/3 weeks) is the established adjuvant stand...
Perioperative factors associated with adverse outcomes in head and neck cancer surgery with free flap reconstruction: A sub-analysis of the HANCOS trial.
235 Background: Head and neck cancer surgeries with free flap reconstruction carry high morbidity, with complication rates...
Inetetamab combined with pyrotinib for neoadjuvant treatment of HER2-positive locally advanced breast cancer (neoPICD): A prospective, multicenter, single-arm phase II trial.
27 Background: Neoadjuvant docetaxel plus carboplatin with trastuzumab and pertuzumab (TCbHP) is the standard regi...
The link between methylation age acceleration and incidence of brain glioblastoma: Two-sample bidirectional and multivariable Mendelian randomization analyses.
173 Background: Glioblastoma is a highly aggressive primary brain tumor strongly associated with increasing chronological...
Investigating the roles of JUP, HMGB1, and FASN knockdown using pro-siRNA mediated regulation on TRAIL and TNF-α induced apoptosis.
84 Background: Evasion of apoptosis is a fundamental hallmark of cancer. Restoring the body’s natural programmed cell deat...
Impact of a structured, nurse-led transitional care model on self-efficacy and unplanned readmissions in patients receiving sequential CAR-T therapy for lymphoma.
251 Background: Sequential CAR-T therapy for relapsed/refractory lymphoma imposes severe physiological and psychological b...
Training tomorrow's oncologists: Impact of the oncology interest group at the Benemérita Universidad Autónoma de Puebla during the 3rd Oncology Congress in Mexico sponsored by ASCO.
341 Background: ASCO fosters oncology training through mentorship programs for students. Oncology Student Interest Group-B...
Heart failure-related mortality in leukemia patients: A 26-year United States surveillance study (1999–2024).
257 Background: Heart failure (HF) is a recognized comorbidity in leukemia patients, driven by cardiac dysfunction and tre...
Baseline COPD, mean lung dose, and longitudinal exhaled nitric oxide for predicting symptomatic radiation pneumonitis in esophageal squamous cell carcinoma: A prospective single-center pilot study.
120 Background: Symptomatic radiation pneumonitis (RP, ≥Grade 2) is a dose-limiting toxicity in esophageal squamous cell c...
<sup>68</sup> Ga-NODAGA-SNA009: A first-in-class single-domain antibody probe for rapid PET imaging of GPA33 in colorectal cancer.
101 Background: GPA33 is a cell-surface glycoprotein highly expressed in normal intestinal epithelium and over 95% of colo...
The University of New Mexico hepatobiliary ECHO: A scalable model for multidisciplinary cancer care.
7 Background: Multidisciplinary team (MDT)-based care is widely recognized as a best practice in management of complex can...
A prospective study comparing response and toxicity with or without nimotuzumab in concurrent chemoradiotherapy in locally advanced head and neck cancer.
224 Background: Head and neck is the second most common in India and seventh most common worldwide malignancy. In...
Multimodal prehabilitation and adherence to perioperative chemotherapy in localized gastroesophageal adenocarcinoma.
140 Background: Perioperative chemotherapy improves survival in resectable gastroesophageal adenocarcinoma (GEA), yet many...
Curcumin analogues and HMOX1-mediated ferroptosis in endometrial cancer.
215 Background: Advanced endometrial cancer remains challenging to treat due to limited therapeutic options and drug resis...