Browse Articles

A fuzzy multi-criteria decision-making framework for the comparative analysis of human and AI influencers

Control of the committed step in lipopolysaccharide biosynthesis

Photoswitchable Molecular Spur Gears: An Entry Point to Motorized Gearing

Nanoscale Spatial Engineering of Ligands Using DNA Origami for Precise Modulation of Membrane Receptor Signaling

ABSTRACT Dimerization or multimerization of surface membrane receptors is essential for transmitting extracellular recognition events across the plasma membrane, triggering intracellular signaling cascades, and regulating a wide range of cellular functions. Ligands typically act as inducers for these processes by binding to receptors, promoting their aggregation and subsequent dimerization or multimerization. The precise spatial arrangement of ligands is crucial for minimizing random collisions and non‐directed migration of receptors on the cell membrane, thereby enhancing signaling fidelity. DNA origami, a highly versatile self‐assembly technique, has emerged as a powerful tool for generating a wide variety of DNA nanostructures. Its exceptional programmability and spatial addressability enable fine‐tuned control over ligand spatial arrangement at the nanoscale, facilitating the precise modulation of surface membrane receptor signaling and enabling user‐defined biological investigations. In this review, we explore the methods used to engineer the spatial arrangement of ligands through DNA origami, highlighting its unique advantages in controlling ligand distance, valence, spatial configuration, and stoichiometry. We also present current applications of DNA origami for modulating membrane receptor signaling, while addressing the key challenges and future directions in achieving precise nanoscale spatial arrangements of ligands for biological and therapeutic purposes.

Efficacy of aminolevulinic acid photodynamic therapy plus CO₂ laser for cervical intraepithelial neoplasia grade 2: a retrospective study

LRRC71 is essential for sperm motility, fertilization, and male fertility

Uncovering and Engineering Mixed-Valence States in Blatter-Type Radicals on Au(111)

A large-scale benchmark shows lightweight models can distinguish matched from mismatched problem–solution pairs across diverse STEM disciplines

GRP75 chaperone-driven mitochondria–ER membrane coupling promotes Ca2+-dependent ROS accumulation and ferroptosis during hypoxic stress

Off–On–Off Probes for Precise Theranostics

Seed germination and seedling growth of spring bread wheat recombinant inbred lines (RILs) under PEG-induced drought stress

Abstract Wheat is one of the staple foods, and its importance is considerable on a global scale. Drought stress significantly affects wheat seed germination. The absence of drought-resistant wheat varieties affects wheat cultivation, especially in arid regions of the world. This study examined seed germination and seedling growth of 147 wheat genotypes subjected to moisture stress induced by polyethylene glycol (PEG). All studied traits showed significant reduction in stress environment in comparison to control (PEG-0%), while MGT and RSR showed increase under stressful condition. The genotype (G), PEG-Treatments (TPEG), and G × TPEG(T PEG ), and the G × T PEG interactions had significant effects on all studied traits ( p  < 0.01), implying considerable variation of genes among the RILs. PCA and cluster analysis revealed a good distinction between tolerant and susceptible genotypes. Elite RILs retained their high SVI, RL, and SHL even in severe osmotic stress conditions, which is a great opportunity for use of those lines in the development of drought tolerant varieties through breeding programs. Nevertheless, PEG osmotic stress is not similar to field drought conditions, and thus the results obtained are indicative of osmotic stress response only. The described genotypic variation represents a very good basis for further QTL and marker-assisted breeding work for improved drought resistance in bread wheat.

Sirtuin 5 knockdown induced the ferroptosis of hepatic stellate cells in hepatic fibrosis progression through de-succinylation modification of GPX4

Outer Membrane–Peptidoglycan Anchoring in <i>Pseudomonas aeruginosa</i>

FL-GQL: a fuzzy logic-guided Q-learning algorithm for global path planning of mobile robots in grid environments

Starvation-induced HSC70 O-GlcNAcylation activates chaperone-mediated autophagy

Correction to “Batch Discovery of Complex Metal Superhydrides via an Effective Machine Learning Method Structured by Chemical Template Concept”

Identifying predictors of mortality among the hospitalized road traffic injury patients: a retrospective case-control study (2022–2024)

microRNAs bidirectionally regulate FUT1 to modulate α-1,2-fucosylation and cancer-associated biology

Wurtzite InP/ZnSe/ZnS Core/Shell Semiconductor Quantum Dots with Bright Near-IR Emission

A Crystalline (Amino)(chloro)Carbene: A Platform for Nucleophilic Substitution at a Carbene Center

ABSTRACT Halogenocarbenes have attracted significant interest for almost a century because they combine classical singlet carbene reactivity with the presence of a readily substituted halogen group. Before this work, no halogenocarbenes had been isolated and taming their instability remained a synthetic challenge. This report describes the preparation of room temperature stable (amino)(chloro)carbenes and examples of their substitution chemistry at the carbene center, unlocking access to a wide range of acyclic carbenes.