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Ginkgolide A enhances cardiomyocyte differentiation from pluripotent stem cells by targeting cytochrome c to attenuate intrinsic apoptosis

Polymorphic Imidoylamidinato Platinum(II) Complex That Exhibits Inverse Symmetry Breaking Induced by Both Pressure and Temperature

Lifetime and acute risk of suicidality by profiles of early life adversity: an observational cohort study in a high-risk population

Abstract Early life adversity in the form of child maltreatment (CM) is a transdiagnostic risk factor for suicidal ideation and behavior (SIB), yet its heterogeneity and relevance for lifetime versus acute SIB and psychotherapy outcomes remain unclear. In an observational cohort of 240 high-risk adults with borderline personality disorder (42.5%) or persistent depressive disorder (57.5%), lifetime and acute SIB were assessed using the Columbia–Suicide Severity Rating Scale. CM profiles were derived using a data-driven clustering approach based on the Childhood Trauma Questionnaire. Associations between CM profiles, SIB, and symptom change during inpatient cognitive behavioral analysis system of psychotherapy (CBASP) or dialectical behavior therapy (DBT) were examined. Seven distinct CM profiles were identified. A profile characterized by physical and emotional abuse and emotional neglect was associated with elevated lifetime risk for active suicidal ideation with plan and intent and for potentially lethal suicide attempts, compared with minimal CM. CM profiles were not associated with acute SIB or their reduction during inpatient psychotherapy, although differential depressive symptom change by CM profile was observed following CBASP but not DBT. These findings suggest that CM profiling may inform lifetime SIB risk assessment and require replication in larger samples.

Structural basis for selective thymidine binding by the Borrelia burgdorferi substrate-binding protein BmpA

Multi-criteria evaluation of circular e-commerce shipping pack alternatives under a spherical fuzzy environment

Abstract This study presents a pure multi-criteria decision-making framework to select circular packaging alternatives for an e-commerce shipping pack that includes the outer box, void filler, sealing tape, and return handling. Packaging decisions in e-commerce are inherently multi-objective: they must protect products and reduce damage, keep total cost low, avoid dimensional-weight penalties, fit recovery infrastructure, and lower life-cycle emissions. These choices are often made with linguistic assessments, uncertain return rates, and heterogeneous customer behaviors across markets. To address this setting, we integrate Spherical Fuzzy Step-wise Weight Assessment Ratio Analysis (SF-SWARA) for criteria weighting and Spherical Fuzzy Combined Compromise Solution (SF-CoCoSo) for alternative ranking. A criteria system is defined to reflect operational and circularity priorities, including protective performance, total cost of ownership, compatibility with local collection and recycling systems, consumer acceptance and convenience, hygiene and contamination risk in returns, feasibility of implementing reverse logistics, and carbon footprint. An expert panel expresses relative importance and alternative performance using spherical fuzzy linguistic terms, and SF-SWARA yields a normalized weight vector. Five alternatives are assessed under the same spherical fuzzy environment: a single-use recyclable pack, a reusable pack, a compostable pack, a deposit-return pack, and a minimal-pack design. SF-CoCoSo generates compromise scores by combining additive and multiplicative principles, enabling balanced choices under conflicting objectives. Robustness is examined through sensitivity analysis that perturbs key weights and by benchmarking rankings against an alternative spherical fuzzy method. The framework provides a transparent, replicable decision aid for e-retailers, third-party logistics providers, and packaging designers, supporting context-specific adoption of circular packaging while safeguarding fulfillment performance and customer experience.

Structure Determination Reveals the Mechanistic Basis of Mannose-6-P Signal Generation by the Dimeric Lysosomal Uncovering Enzyme NAGPA

The Cytosolic Zinc Finger Domain Structure of the CCHFV Glycoprotein n Is Maintained in Its Membrane-Bound Form

Effects of microbial fertilizers on photosynthetic characteristics and enzyme activities of oil sunflower under combined saline–alkali stress

LeGenD: High-throughput N-glycan profiling using explainable AI and lectin profiling

Suppressing Phase Segregation and Improving Stability in Mixed-Halide Perovskites through Spinel Oxide-Directed Epitaxy

Correction: Associations of adverse childhood experiences and depressive symptoms among children and adolescents: the mediating effect of resilience and sleep quality

LATS kinase activity and tumor suppressor function are regulated by a second autophosphorylation site

Near‐100% Selective Photocatalytic Methane‐to‐Methanol Conversion Enabled by Synergistic Chlorine Radicals and Oxygen Vacancies

ABSTRACT The selective photocatalytic conversion of methane to a single product is a grand challenge, primarily due to uncontrollable over‐oxidation and inefficient reduction. Herein, we pioneer a radical/active‐site synergistic strategy to steer the reaction pathway exclusively toward methanol. This is realized by a dual‐functional Cl─TiO 2 ‐OV catalyst that integrates chlorine modification and oxygen vacancy (OV) engineering. Crucially, surface chlorine redirects the oxidation route: instead of generating non‐selective •OH radicals from H 2 O, photogenerated holes preferentially drive a Cl − /Cl• cycle. The resulting Cl• radicals activate the C─H bond of CH 4 to form •CH 3 , which combines with O 2 to yield the CH 3 OOH intermediate. Simultaneously, the engineered OV sites act as electron‐rich centers that efficiently reduce CH 3 OOH to CH 3 OH. This decoupling of selective oxidation (via Cl•) and efficient reduction (via OVs) suppresses all side‐reactions, delivering methanol with nearly 100% selectivity and a yield of 1242 µmol g −1 . In contrast, TiO 2 ‐OV suffers from •OH‐mediated sequential oxidation to HCHO/CO 2 , and Cl─TiO 2 lacks sufficient reduction power, resulting in a CH 3 OOH/CH 3 OH mixture. This work not only offers an effective approach for highly selective photocatalytic methane conversion but also deepens mechanistic insight into radical/active‐site cooperativity in synergistic catalysis.

Lightweight dual-backbone network with attentional fusion for wound image classification

SARS-CoV-2 5′-UTR stem-loops activate the antiviral protein oligoadenylate synthetase 1 (OAS1)

Fine-Tuning the Coordination Structure and Identifying Pt ₁ –O _v –Ce as the Active Site for Selective Hydrogenations over Pt ₁ /CeO ₂ Single-Atom Catalysts

Correction: Effect of microencapsulated sodium butyrate on abdominal symptoms and carbohydrate metabolism in patients with type 2 diabetes: a randomized placebo-controlled trial

Macrophage-specific targeting of histone demethylases with small-molecule inhibitors suppresses inflammatory response in vivo

Phototheranostic Sutures Integrated with NIR-II Emissive Photosensitizers for Postoperative Complication Prevention and Non-invasive Monitoring

Outside Front Cover: Toward Multi(radio)Metalated DNA: Enzymatic Polymerization of Metal‐Chelate‐Modified Deoxyribonucleoside Triphosphates (Angew. Chem. Int. Ed. 27/2026)