A Crystalline (Amino)(chloro)Carbene: A Platform for Nucleophilic Substitution at a Carbene Center
Abstract
ABSTRACT Halogenocarbenes have attracted significant interest for almost a century because they combine classical singlet carbene reactivity with the presence of a readily substituted halogen group. Before this work, no halogenocarbenes had been isolated and taming their instability remained a synthetic challenge. This report describes the preparation of room temperature stable (amino)(chloro)carbenes and examples of their substitution chemistry at the carbene center, unlocking access to a wide range of acyclic carbenes.
Article Details
Authors (8)
Wenyi Dong
UCSD‐CNRS Joint Research Chemistry Laboratory (IRL 3555) Department of Chemistry and Biochemistry University of California San Diego La Jolla USA
Mehdi Abdellaoui
UCSD‐CNRS Joint Research Chemistry Laboratory (IRL 3555) Department of Chemistry and Biochemistry University of California San Diego La Jolla USA
Daniel Chan
UCSD‐CNRS Joint Research Chemistry Laboratory (IRL 3555) Department of Chemistry and Biochemistry University of California San Diego La Jolla USA
François Vermersch
UCSD‐CNRS Joint Research Chemistry Laboratory (IRL 3555) Department of Chemistry and Biochemistry University of California San Diego La Jolla USA
Patrick Yorkgitis
UCSD-CNRS Joint Research Laboratory (IRL 3555), Department of Chemistry and Biochemistry
Mohand Melaimi
UCSD‐CNRS Joint Research Chemistry Laboratory (IRL 3555) Department of Chemistry and Biochemistry University of California San Diego La Jolla USA
Michèle Soleilhavoup
UCSD‐CNRS Joint Research Chemistry Laboratory (IRL 3555) Department of Chemistry and Biochemistry University of California San Diego La Jolla USA
Guy Bertrand
UCSD-CNRS Joint Research Laboratory (IRL 3555), Department of Chemistry and Biochemistry