A Hormone Cell Atlas maps the human endocrine system at cellular resolution
Abstract
Hormones act across tissues and organs to coordinate physiological functions. Drawing inspiration from the Human Cell Atlas, we analyzed the expression of 379 hormone and receptor genes in a transcriptomic dataset comprising 14 million single cells and nuclei across 47 human tissues. Using hormone2cell, we mapped putative hormone-producing and hormone-receiving cell types, defining tissue-specific and cross-tissue endocrine signatures. We predicted nonclassical sites of hormone expression, including secretin in plasmacytoid dendritic cells, inferred convergent hormone action and endocrine feedback loops, and implicated cell populations in monogenic endocrine disorders. In a cross-tissue integration of adipocyte datasets, we uncovered dynamic endocrine programs across depots, within adipocyte subtypes and through adipogenic differentiation. Cumulatively, the Hormone Cell Atlas ( hormonecellatlas.org.uk ) provides a comprehensive framework for dissecting hormonal impact on health and disease.
Article Details
Journal Info
Science
American Association for the Advancement of Science
Authors (23)
Lijiang Fei
Isabel Huang-Doran
Institute of Metabolic Science Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK.
Katherine Lawler
Institute of Metabolic Science Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK.
Yizhou Yu
Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Jan Patrick Pett
Kevin M. Méndez-Acevedo
Institute of Metabolic Science Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK.
Dinesh Shah
Institute of Metabolic Science Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK.
Jaume Margalef-Rieres
Institute of Metabolic Science Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK.
Joseph S. Pohlman
Institute of Metabolic Science Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK.
Batuhan Cakir
Madelyn R. Moy
Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Robert G. Legg
Institute of Metabolic Science Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK.
Chuan Xu
Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Ken To
Duy Pham
Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Alexander V. Predeus
Ruth Hanssen
Institute of Metabolic Science Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK.
Tessa M. Cacciottolo
Institute of Metabolic Science Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK.
Rakesh K. Kapuge
Cambridge Stem Cell Institute, University of Cambridge, Cambridge, UK.
Krzysztof Polanski
Amanda J. Oliver
Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge, UK.
Sarah A. Teichmann
I. Sadaf Farooqi
Institute of Metabolic Science Metabolic Research Laboratories and NIHR Cambridge Biomedical Research Centre, Addenbrooke’s Hospital, Cambridge, UK.