Science
Articles in this Issue
Detention of U.S. seismologist by China alarms researchers
Youlin Chen analyzed earthquake data that can also aid nuclear test monitoring
Single-cell multiomics and chromatin structure reveal gene-regulatory dynamics in heart failure
Heart failure is a leading cause of morbidity and mortality, yet gene-regulatory mechanisms driving cell type–specific pathologic responses remain undefined. Here, we present the cell type–resolved tr...
No strain, no gain
A modular approach could expand the repertoire of spring-loaded covalent drugs
Single-cell multiomics connects 3D genome and transcriptome alterations in Alzheimer’s disease
Alzheimer’s disease (AD) disrupts brain function through cell type–specific transcriptomic and epigenomic alterations, yet the contribution of three-dimensional (3D) genome organization to AD remains...
Spatially resolving the cone of reaction for a single molecule
Collisions of atoms and molecules are required for bond formation and are thus key to any chemical reaction. Their outcome is determined by the collision energy, relative orientation, and impact param...
The rise and fall of language diversity through the Holocene
Characterizing the factors that have shaped linguistic diversity is fundamental for understanding human history, culture, and cognition. In this study, we combined statistical and social computational...
In Science Journals
Highlights from the Science family of journals
A tiny cone of reactivity
Colliding molecules react only when their orientations and point of impact fall within a narrow range
Alzheimer’s trial results lend momentum to drugs targeting tau
First drug to lower the protein and slow cognitive decline created buzz despite puzzling data
Contagious fish cancer overruns New England lake
Genetic studies reveal rare example of identical transmissible tumors
Prominent Salk Institute biologist to resign following sexual misconduct investigation
Staffers complain that Salk allowed circadian rhythms researcher Satchidananda Panda to depart quietly, while the allegations and findings remain under wraps
A 3D genome atlas of human tonsil and the role of loop extrusion in B cell somatic hypermutation
B cell maturation within the germinal center tissue microenvironment involves immunoglobulin gene diversification by somatic hypermutation (SHM). How three-dimensional (3D) genome architecture influen...