Nature
Articles in this Issue
Testosterone therapy is trending. Who really needs it, and why?
Marvellous microscopes impress guests at a London party
Exapted CRISPR–Cas12f homologues drive RNA-guided transcription
AI agents in research: when productivity comes at the cost of apprenticeship
Precision medicine without equity is just stratified inequality
Legal rights for insects: a global imperative for stingless-bee conservation
The molecular basis of force selectivity by PIEZO2
Abstract PIEZOs are mechanically gated ion channels that transduce force into electrochemical signals 1 . PIEZO1 responds...
These powerful tools reveal the ‘control knobs’ of the genome
Precancerous niche remodelling dictates nascent tumour persistence
Abstract Interactions between mutant cells and their environment have a key role in determining cancer susceptibility 1–3...
Lipid metabolism drives dietary effects on T cell ferroptosis and immunity
Structural basis of RNA-guided transcription by a dCas12f–σE–RNAP complex
European funder must increase capacity to meet the ambition of scientists
Forest pests hit trees hard as temperatures rise
Blood test hints at breast-tumour response to treatment
An electrifying test to find a good coffee
Algorithm that gets ‘under the hood’ of AI models could effectively steer their responses
Adaptive evolution of gene regulatory networks in mammalian neocortex
Synthetic super-enhancers enable precision viral immunotherapy
Abstract Cell-type-specific promoters are used in gene therapy to restrict expression of the therapeutic payload. However, these promoters often have suboptimal...
Biosynthesis of cinchona alkaloids
Abstract Cinchona alkaloids, which have been studied for more than 250 years, are plant-derived natural products that have collectively had a substantial impact...
Local agricultural transition, crisis and migration in the Southern Andes
Uncertain dynamic response of mid-latitude winter precipitation
Digital quantum magnetism on a trapped-ion quantum computer
Tumour trap: engineered enhancer sequences enlisted to kill cancer cells
Charge-dependent spectral softenings of primary cosmic rays below the knee
Single-cell spatiotemporal dissection of the human maternal–fetal interface
Abstract The human maternal–fetal interface is characterized by mosaic intermingling of maternal and fetal cells 1 . Yet...