Nature
Articles in this Issue
Somatic mutation and selection at population scale
Abstract As we age, many tissues become colonized by microscopic clones carrying somatic driver mutations 1–7 . Some of t...
Ultra-sensitive DNA sequencing maps mutations that precede cancer
Sperm sequencing reveals extensive positive selection in the male germline
Abstract Mutations that occur in the cell lineages of sperm or eggs can be transmitted to offspring. In humans, positive selection of driver mutations during spe...
Sex and smoking bias in the selection of somatic mutations in human bladder
Abstract Men are at higher risk of several cancer types than women 1 . For bladder cancer the risk is four times higher f...
Electromagnetic interference shielding using metal and MXene thin films
Hotspots of human mutation point to clonal expansions in spermatogonia
Abstract In renewing tissues, mutations conferring selective advantage may result in clonal expansions 1–4 . In contrast...
Structural basis for mTORC1 activation on the lysosomal membrane
Abstract The mechanistic target of rapamycin complex 1 (mTORC1) integrates growth factor (GF) and nutrient signals to stimulate anabolic processes connected to c...
Retraction Note: sFRP2 in the aged microenvironment drives melanoma metastasis and therapy resistance
Atomically resolved edges and defects in lead halide perovskites
Selective presynaptic inhibition of leg proprioception in behaving Drosophila
Mechanical confinement governs phenotypic plasticity in melanoma
Abstract Phenotype switching is a form of cellular plasticity in which cancer cells reversibly move between two opposite extremes: proliferative versus invasive...
Three rising stars in ageing research
Is ageing a disease? The debate that could reshape medicine
Ultrathin films of a 2D polymer provide airtight seal
How much protein do you really need? What the science says
GREGoR: accelerating genomics for rare diseases
To reform universities, first tackle global rankings
Could humans live to 150? Why some researchers think we’re on the cusp of a major longevity breakthrough
A new paradigm for outer membrane protein biogenesis in the Bacteroidota
Abstract In Gram-negative bacteria, the outer membrane is the first line of defence against antimicrobial agents and immunological attacks 1...
Aligning machine and human visual representations across abstraction levels
Abstract Deep neural networks have achieved success across a wide range of applications, including as models of human behaviour and neural representations in vis...