Nature
Articles in this Issue
Mysterious ‘little red dots’ could be black holes in disguise
Little red dots as young supermassive black holes in dense ionized cocoons
Abstract The James Webb Space Telescope (JWST) has uncovered many compact galaxies at high redshift with broad hydrogen and helium lines, including the enigmatic...
Credit in research goes hand in hand with responsibility
The asymmetric synthesis of an acyclic N-stereogenic amine
Abstract Most molecules in chemistry and biology are chiral, leading to mirror-image variants, so-called enantiomers. However, although the selective chemical sy...
Earliest evidence of making fire
Semantic design of functional de novo genes from a genomic language model
Abstract Generative genomic models can design increasingly complex biological systems 1 . However, controlling these mode...
Cross-regulation of [2Fe–2S] cluster synthesis by ferredoxin-2 and frataxin
LLMs behaving badly: mistrained AI models quickly go off the rails
Rewiring an olfactory circuit by altering cell-surface combinatorial code
Abstract Proper brain function requires the precise assembly of neural circuits during development. Despite the identification of many cell-surface proteins (CSP...
Enriching African genome representation through the AGenDA project
Six steps to protect researchers’ digital security
Repulsions instruct synaptic partner matching in an olfactory circuit
Abstract Neurons exhibit extraordinary precision in selecting synaptic partners. Although cell-surface proteins (CSPs) that mediate attractive interactions betwe...
Mutations in mitochondrial ferredoxin FDX2 suppress frataxin deficiency
Abstract Frataxin is a key component of an ancient, mitochondrial iron–sulfur cluster biosynthetic machinery, serving as an allosteric activator of the cysteine...
Structural basis of regulated N-glycosylation at the secretory translocon
Abstract Most human secretory pathway proteins are N-glycosylated by oligosaccharyltransferase (OST) complexes as they enter the endoplasmic reticulum (ER)...
Exciplex-enabled high-efficiency, fully stretchable OLEDs
Training large language models on narrow tasks can lead to broad misalignment
Abstract The widespread adoption of large language models (LLMs) raises important questions about their safety and alignment 1...
Direct observation of the Migdal effect induced by neutron bombardment
Abstract The search for dark matter focuses now on hypothetical light particles with masses ranging from MeV to GeV (refs. 1–12...