Nature Communications
Articles in this Issue
Genomic and epigenomic maps of mouse centromeres and pericentromeres
Injectable bioresorbable conductive hydrogels for multimodal brain tumor electroimmunotherapy
Abstract Current electrode technologies are too rigid for safe and effective delivery of electrotherapy in the brain, and patients with glioblastoma continue to face a devastating pr...
Conservative port-to-port funneling of light in nonlinear photonic lattices
Observation of returning Thouless pumping
Rethinking infrastructure design from component failure to systemic resilience
Abstract Bridge design typically uses load-based design criteria focused on risk thresholds from engineering practice and standards, overlooking cascading effects on connected infras...
Development and validation of a clinical wearable deep learning based continuous inhospital deterioration prediction model
Unveiling the cut-and-repair cycle of designer nucleases in human stem and T cells via CLEAR-time dPCR
Abstract DNA repair mechanisms in human primary cells, including error-free repair, and, recurrent nuclease cleavage events, remain largely uncharacterised. We elucidate gene-editing...
Mitochondrial ABHD11 inhibition drives sterol metabolism to modulate T-cell effector function
Abstract α/β-hydrolase domain-containing protein 11 (ABHD11) is a mitochondrial hydrolase that maintains the catalytic function of α-ketoglutarate dehydrogenase (α-KGDH), and its exp...
Structure of the human astrovirus capsid spike in complex with the neonatal Fc receptor
Abstract Human astroviruses (HAstVs) are a leading cause of viral gastroenteritis in children worldwide. Recently the neonatal Fc receptor (FcRn) was identified as a receptor for HAs...
Genome-wide analysis of heart failure yields insights into disease heterogeneity and enables prognostic prediction in the Japanese population
Basal mantle structure regenerated through supercontinents
Direct ambient photopatterning of RGB quantum dots for light-emitting diodes with EQE exceeding 20%
Comparing the motion of dark matter and standard model particles on cosmological scales
Modeling and addressing on-target/off-tumor toxicity of claudin 18.2 targeted immunotherapies
On-target off-tumor toxicity of claudin18.2-directed CAR-T cells in preclinical models
Increasing wintertime cloud opacity increases surface longwave radiation at a long-term Arctic observatory
Abstract As the Arctic warms, winter clouds are known and expected to change. Yet the extent to which these cloud changes amplify or dampen warming (cloud feedba...
Damascus-style hierarchical microstructures enable a strong and ductile medium-entropy alloy
Light-adaptive interfacial solar steam evaporation enhanced by dynamic water gating
Hidden network preserved in Slide-tags data allows reference-free spatial reconstruction
Abstract Spatial transcriptomics technologies aim to spatially map gene expression in tissues and typically use oligonucleotide array surfaces that have undergone spatial indexing. T...
Engineering polar nanoclusters for enhanced microwave tunability in ferroelectric thin films
Abstract Microwave tunable thin films that can dynamically adjust dielectric properties are essential for next-generation communication and sensing technologies. However, achieving h...
Coupled strontium-calcium isotopes in Archean anorthosites reveal a late start for mantle depletion
Abstract Voluminous felsic continental crust is, as far as we know, unique to Earth, yet the timescales of its earliest growth remain debated. Archean mantle evo...
Surface mechanics and compressive stress impact mammalian follicle development
Bow shock oscillations of Mars under weakly disturbed solar wind conditions
Abstract Bow shock, where the solar wind first encounters the Martian environment, reflects the complex interplay between the solar wind and Martian upper atmosphere and crustal fiel...
Astrocytes distress triggers brain pathology through induction of δ secretase in a murine model of Alzheimer’s disease
Abstract The importance of astrocytes for Alzheimer’s disease (AD) pathology is increasingly appreciated, yet the mechanisms whereby this cell type impacts neurodegenerative processe...