Nature Communications
Articles in this Issue
Reading signatures of supermassive binary black holes in pulsar timing array observations
Abstract Constraining the origin of the nanohertz gravitational-wave background necessitates precise noise modelling to avoid parameter estimation biases. In thi...
Increasing temperatures affect thoracic muscle performance in Arctic bumblebees
Abstract Increasing temperature beyond a species’ optimum is a major threat to insect biodiversity, particularly in rapidly warming regions such as the Arctic. For cold-adapted polli...
Hypoxic-ischemic brain injury in neonatal mice sequentially recruits neutrophils with dichotomous phenotype and function
Abstract Neonatal encephalopathy caused by hypoxia-ischemia (HI) leads to a strong neutrophil infiltration. The long-held assumption that neutrophils act exclusively as tissue-damagi...
Self-referencing ultrafast wide-field pump-probe microscopy
High-throughput printing of functionally gradient material from self-propagation
Transposon invasion of primate genomes shaped human inflammatory enhancers and susceptibility to inflammatory diseases
Abstract Human inflammatory response reflects adaptive alteration of immune-cell regulatory elements during human evolution. Yet the impact of the deeper evolutionary history of thes...
Biomimetic self-reinforcing recyclable biomass-derived inherently-safe sustainable materials
AI-powered spatial cell phenomics enhances risk stratification in non-small cell lung cancer
Abstract Risk stratification remains a critical challenge in non-small cell lung cancer patients for optimal therapy selection. In this study, we develop an artificial intelligence-p...
Structural insights into context-specific inhibition of bacterial translation by macrolides
Systematic evidence grading evaluates multisystemic associations and risks of vitiligo
Neutralizing antibodies against Chikungunya virus and structural elucidation of their mechanism of action
Enhanced sensitivity for electron affinity measurements of rare elements
Abstract The electron affinity (EA), the energy released when a neutral atom binds an additional electron, is a fundamental property of atoms that is governed by...
Reference-based chemical-genetic interaction profiling to elucidate small molecule mechanism of action in Mycobacterium tuberculosis
Abstract We previously reported an antibiotic discovery screening platform that identifies whole-cell active compounds with high sensitivity while simultaneously...
Determination of key functional structures of an amorphous VHL-based SMARCA2 PROTAC
Abstract Proteolysis targeting chimeras (PROTACs) enable degradation of disease-related proteins via E3 ligase recruitment. PROTACs often do not easily crystallize, and they are usua...
Tuning relaxation and nonlinear upconversion of valley-exciton-polaritons in a monolayer semiconductor
Abstract Controlling exciton relaxation and energy conversion pathways via their coupling to photonic modes is a central task in cavity-mediated quantum material...
Elevating cytosolic NADPH metabolism in endothelial cells ameliorates vascular aging
Powerful one-dimensional scan to detect heterotic quantitative trait loci
Abstract To meet the growing global demand for food, increasing yields through heterosis in agriculture is crucial. A deep understanding of the genetic basis of heterosis has led to...
An enzymatic cascade enables sensitive and specific proximity labeling proteomics in challenging biological systems
Abstract Ascorbate peroxidase (APEX) is a proximity labeling enzyme used for subcellular proteomics at high spatial and temporal resolution. However, toxicity of...
Targeting cancer glutamine dependency with a first-in-class inhibitor of the mitochondrial glutamine transporter SLC1A5_var
Camrelizumab plus chemotherapy versus chemoradiotherapy as neoadjuvant therapy for resectable esophageal squamous cell carcinoma: Phase 2 randomized trial (REVO)
Antibiotic resistance selection and deselection in municipal wastewater from 47 countries
Abstract Wastewaters are plausible arenas for antibiotic resistance evolution and transmission, yet selection for resistance by municipal wastewater has rarely b...
Chiral supramolecular assembly to enhance the magneto-optical rotation of organic materials
Abstract Connections between magnetic field induced optical activity and chirality have a rich and complicated history. Although the broken inversion symmetry of...