On-target off-tumor toxicity of claudin18.2-directed CAR-T cells in preclinical models

Filippo Birocchi; Antonio J. Almazan; Aiyana Parker; Amanda A. Bouffard; Sadie Goncalves; Christopher Kelly; Jessica Frank; Mark B. Leick; Nicholas J. Haradhvala; Shaw Kagawa; Gad Getz; Giulia Escobar; Diego Salas-Benito; Adele Mucci; Trisha R. Berger; Marcela V. Maus

doi:10.1038/s41467-025-61858-z

On-target off-tumor toxicity of claudin18.2-directed CAR-T cells in preclinical models

F Filippo Birocchi A Antonio J. Almazan A Aiyana Parker A Amanda A. Bouffard S Sadie Goncalves C Christopher Kelly (Centre for the Developing Brain, Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King’s College London) J Jessica Frank M Mark B. Leick N Nicholas J. Haradhvala S Shaw Kagawa G Gad Getz G Giulia Escobar D Diego Salas-Benito A Adele Mucci T Trisha R. Berger M Marcela V. Maus

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Article Details

Journal Nature Communications

Volume / Issue Vol. 16, Issue 1

Published November 01, 2025

DOI 10.1038/s41467-025-61858-z

ISSN 2041-1723

Publisher Nature Portfolio

Journal Info

Nature Communications

Nature Portfolio

ISSN: 2041-1723 Open Access Life Sciences

Authors (16)

F

Filippo Birocchi

A

Antonio J. Almazan

A

Aiyana Parker

A

Amanda A. Bouffard

S

Sadie Goncalves

C

Christopher Kelly

Centre for the Developing Brain, Research Department of Early Life Imaging, School of Biomedical Engineering and Imaging Sciences, King’s College London

J

Jessica Frank

M

Mark B. Leick

N

Nicholas J. Haradhvala

S

Shaw Kagawa

G

Gad Getz

G

Giulia Escobar

D

Diego Salas-Benito

A

Adele Mucci

T

Trisha R. Berger

M

Marcela V. Maus

On-target off-tumor toxicity of claudin18.2-directed CAR-T cells in preclinical models

Article Details

Journal Info

Authors (16)

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