Nature Communications
Articles in this Issue
Multi-omics profiling reveals atypical sugar utilization and a key membrane composition regulator in Streptococcus pneumoniae
Abstract The human body comprises many different microenvironments, each with their own challenges for microorganisms to overcome in order to survive and possibl...
Author Correction: Ketamine activates adult-born immature granule neurons to rapidly alleviate depression-like behaviors in mice
Mechanism of cooperative strigolactone perception by the MAX2 ubiquitin ligase–receptor–substrate complex
Estimation of genome-wide coupling in rattlesnake hybrids provides insight into the process of speciation and its progress
Induction chemotherapy plus camrelizumab followed by concurrent chemoradiotherapy in unresectable locally advanced esophageal squamous cell carcinoma: a single-arm phase II trial
Abstract Concurrent chemoradiotherapy (CCRT) has remained the standard treatment for unresectable locally advanced esophageal squamous cell carcinoma (ESCC), yet survival remains poo...
Benchmarking informatics workflows for data-independent acquisition single-cell proteomics
Abstract Recent years have seen a rise of single-cell proteomics by data-independent acquisition mass spectrometry (DIA MS). While diverse data analysis strategies have been reported...
Multiscale red blood cell hitchhiking for targeted deep tissue gene delivery in lungs
Abstract The clinical impact of gene therapies is constrained by poor delivery to target tissues beyond the liver after intravenous administration. Current molecular targeting strate...
Chemical weathering of molecular single crystals to monoliths of quantum dots
A hindrance-plane-hindrance molecular engineering strategy towards self-assembled nanorods for enhanced photodynamic therapy
Serum Proteomics Reveals Diagnostic Biomarkers and Molecular Pathways in Cerebral Palsy
Abstract Cerebral palsy (CP), a prevalent non-progressive neurological disorder in children, lacks reliable biomarkers for early diagnosis, and its molecular mechanisms remain poorly...
Mapping of HOCl-oxidized RNA identifies abasic sites as major damage and oxidation product of oxo8G
Abstract RNA oxidation is an important yet understudied process, partly because methods to localize oxidized residues in RNA are lacking. We introduce OAbSeq, a...
A mass spectrometry-based strategy allows signature metabolite identification in tear fluid from people with diabetic cataracts
Replay without sharp wave ripples in a spatial memory task
Abstract Sharp-wave ripples and hippocampal replay are widely viewed as inseparable components of episodic memory consolidation, with ripples broadcasting the episodic content carrie...
Climate, air quality, and equity benefits from hydrogen substitution for fossil fuels used in process heat
Remodeling of the immune microenvironment is linked to adverse outcome in pediatric T cell acute lymphoblastic leukemia
Unifying regulatory motifs in endocrine circuits
Visible Brillouin-quadratic microlaser in a high-Q thin-film lithium niobate microdisk
Desaturase-dependent secretory functions of hepatocyte-like cells control systemic lipid metabolism during starvation in Drosophila
Abstract Similar to the mammalian hepatocytes, Drosophila oenocytes accumulate fat during fasting, but it is unclear how...
Spermine modulation of Alzheimer’s Tau and Parkinson’s α-synuclein: implications for biomolecular condensation and neurodegeneration
Abstract Spermine, a pivotal player in biomolecular condensation and diverse cellular processes, has emerged as a focus of investigation in aging, neurodegenerat...
Author Correction: Intensification of extreme cold events in East Asia in response to global mean sea-level rise
High-resolution national mapping of natural gas composition substantially updates methane leakage impacts
Gradient descent in materia through homodyne gradient extraction
Abstract Deep learning, a multilayered neural-network approach inspired by the brain, has revolutionized machine learning. Its success relies on backpropagation, which computes gradi...
Hidden in plain heat: anomalous Lorenz number in the thermoelectric alloy Bi0.4Sb1.6Te3
Cross-dataset pan-cancer detection by correlating cell-free DNA fragment coverage with open chromatin sites across cell types
Multi-scale Interaction Mechanism for Edge-Localized-Mode Suppression in the Tokamak Edge
Abstract A central challenge in fusion energy is reconciling the high-confinement mode required for reactor performance with the intense intermittent relaxation events it produces, k...