Nature Communications
Articles in this Issue
Fructose and follistatin potentiate acute MASLD during complete hepatic insulin resistance
Motif-based models accurately predict cell type-specific distal regulatory elements
Abstract Deciphering how DNA sequence specifies cell-type-specific regulatory activity is a central challenge in gene regulation. We present Bag-of-Motifs (BOM),...
Observing growth of metallic crystals inside liquid metal solvents
Multi-ancestry investigation of the genomics of erectile dysfunction
Abstract Erectile dysfunction is attributable to numerous biological and psychological issues, and its prevalence increases with age. We conducted genome-wide as...
Structural basis of lipopolysaccharide assembly by the outer membrane translocon holo-complex
Abstract Lipopolysaccharide (LPS) assembly at the surfaces-exposed leaflet of the bacterial outer membrane (OM) is mediated by the OM LPS translocon. An essential transmembrane β-bar...
Targeted sequencing and iterative assembly of near-complete genomes
Interactions between motor cortical forelimb regions and their influence on muscles reorganize across behaviors
Strategic atomic trapping at heterointerfaces for protonic ceramic cells
Thinning Antarctic glaciers expose high-altitude nunataks delivering more bioavailable iron to the Southern Ocean
Abstract Glacial systems entrain and transfer sediment, rich in essential nutrients, from continental sources to the ocean, where they are released by meltwater....
Resonance-free Fabry-Pérot cavity via unrestricted orbital-angular-momentum ladder-up
Hundred-layer photonic deep learning
WEE1 inhibitors trigger GCN2-mediated activation of the integrated stress response
Efficient event-based delay learning in spiking neural networks
Abstract Spiking Neural Networks compute using sparse communication and are attracting increased attention as a more energy-efficient alternative to traditional Artificial Neural Net...
Functional synaptic connectivity of engrafted spinal cord neurons with hindlimb motor circuitry in the injured spinal cord
A ternary switch model governing ERα ligand binding domain conformation
Self-regulating and self-oscillating metal-organic framework hybrid plasmonic metasurfaces
Abstract Metal-organic frameworks (MOFs) offer remarkable chemical versatility, structural diversity, and, in some cases, stimuli-responsiveness. In the latter case, they typically r...
Hydrodynamic spin-pairing and active polymerization of oppositely spinning rotors
Single-nucleus and spatial transcriptomic profiling of human temporal cortex and white matter reveals key associations with AD pathology
Synthetic fascia for stiff and tough 4D printed multifunctional structures that detect and tolerate damage
Abstract Creating shape-morphing structures with time-responsive materials is a key goal of 4D printing, but combining high stiffness ( E...
Automated MRI system for clinically significant prostate cancer detection development validation and real-world implementation
Abstract Prostate MRI enables detection of clinically significant prostate cancer (csPCa), yet variability in PI-RADS scoring limits reproducibility and throughput. Here, we report t...
Efficient electrodynamic stripping for 12-inch wafer-scale freestanding ferroelectric oxide membranes
Disentangling the mechanistic role of loop-C capping in Cys-loop receptor activation
Abstract A comparison of atomic models of Cys-loop receptors reveals that the largest rearrangement upon agonist binding and gating is the contraction (“capping”) of the neurotransmi...