Nature Communications
Articles in this Issue
Structural basis for catalysis and selectivity of phospholipid synthesis by eukaryotic choline-phosphotransferase
Oriented wide-bandgap perovskites for monolithic silicon-based tandems with over 1000 hours operational stability
A simple model for Behavioral Time Scale Synaptic Plasticity (BTSP) provides content addressable memory with binary synapses and one-shot learning
Abstract Recent experimental studies in the awake brain have identified a rule for synaptic plasticity that is instrumental for the instantaneous creation of memory traces in area CA1 of the...
Overlapping qubits from non-isometric maps and de Sitter tensor networks
AbstractThe emergence of a local effective theory from a more fundamental theory of quantum gravity with seemingly fewer degrees of freedom is a major puzzle of theoretical physics. A recent approach...
Gene-editing in patient and humanized-mice primary muscle stem cells rescues dysferlin expression in dysferlin-deficient muscular dystrophy
AbstractDystrophy-associated fer-1-like protein (dysferlin) conducts plasma membrane repair. Mutations in the DYSF gene cause a panoply of genetic muscular dystrophies. We targeted a frequent loss-of-...
Development of small molecule non-covalent coronavirus 3CL protease inhibitors from DNA-encoded chemical library screening
Robust skin-integrated conductive biogel for high-fidelity detection under mechanical stress
Catalyst-controlled directing group translocation in the site selective C–H functionalization of 3-carboxamide indoles and metallocarbenes
Structural insights into distinct mechanisms of RNA polymerase II and III recruitment to snRNA promoters
Long non-coding RNAs direct the SWI/SNF complex to cell type-specific enhancers
AbstractThe coordination of chromatin remodeling is essential for DNA accessibility and gene expression control. The highly conserved and ubiquitously expressed SWItch/Sucrose Non-Fermentable (SWI/SNF...
Unusual violation of the Wiedemann–Franz law at ultralow temperatures in topological compensated semimetals
Nano-island-encapsulated cobalt single-atom catalysts for breaking activity-stability trade-off in Fenton-like reactions
The glycerol stabilized calcium phosphate cluster for rapid remineralization of tooth enamel by a water-triggered transformation
Molecular and spatial analysis of tertiary lymphoid structures in Sjogren’s syndrome
AbstractTertiary lymphoid structures play important roles in autoimmune and non-autoimmune conditions. While many of the molecular mechanisms involved in tertiary lymphoid structure formation have bee...
Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants
Mms22-Rtt107 axis attenuates the DNA damage checkpoint and the stability of the Rad9 checkpoint mediator
Ultra robust negative differential resistance memristor for hardware neuron circuit implementation
Wearable electrodriven switch actively delivers macromolecular drugs to fundus in non-invasive and controllable manners
Electronic structure formed by Y2O3-doping in lithium position assists improvement of charging-voltage for high-nickel cathodes
Intravenous liposomal irinotecan in metastatic triple-negative breast cancer after ≥ 2 prior lines of chemotherapy: a phase Ib study
Remodelling of the immune landscape by IFNγ counteracts IFNγ-dependent tumour escape in mouse tumour models
Abstract Loss of IFNγ-sensitivity by tumours is thought to be a mechanism enabling evasion, but recent studies suggest that IFNγ-resistant tumours can be sensiti...
Predicting thermodynamic stability of inorganic compounds using ensemble machine learning based on electron configuration
Structural insights into the mechanism of phosphate recognition and transport by XPR1
Liver-specific gene PGRMC1 blocks c-Myc-induced hepatocarcinogenesis through ER stress-independent PERK activation
The molecular reach of antibodies crucially underpins their viral neutralisation capacity
Abstract Key functions of antibodies, such as viral neutralisation, depend on high-affinity binding. However, viral neutralisation poorly correlates with antigen affinity for reasons that ha...