Nature Communications
Articles in this Issue
Nucleophilic addition of bulk chemicals with imines using N-functionalized hydroxylamine reagents as precursors
Self-assembled hole-selective contact for efficient Sn-Pb perovskite solar cells and all-perovskite tandems
C–C bond coupling with sp3 C–H bond via active intermediates from CO2 hydrogenation
TOPS-speed complex-valued convolutional accelerator for feature extraction and inference
AbstractComplex-valued neural networks process both amplitude and phase information, in contrast to conventional artificial neural networks, achieving additive capabilities in recognizing phase-sensit...
In vivo spontaneous Ca2+ activity in the pre-hearing mammalian cochlea
AbstractThe refinement of neural circuits towards mature function is driven during development by patterned spontaneous calcium-dependent electrical activity. In the auditory system, this sensory-inde...
Probing SARS-CoV-2 membrane binding peptide via single-molecule AFM-based force spectroscopy
AbstractThe SARS-CoV-2 spike protein’s membrane-binding domain bridges the viral and host cell membrane, a critical step in triggering membrane fusion. Here, we investigate how the SARS-CoV-2 spike pr...
Immunoassay detection of multiphosphorylated tau proteoforms as cerebrospinal fluid and plasma Alzheimer’s disease biomarkers
Generation of perthiyl radicals for the synthesis of unsymmetric disulfides
Degradation bottlenecks and resource competition in transiently and stably engineered mammalian cells
Abstract Degradation tags, otherwise known as degrons, are portable sequences that can be used to alter protein stability. Here, we report that degron-tagged proteins compete for cel...
Dynamic representation of appetitive and aversive stimuli in nucleus accumbens shell D1- and D2-medium spiny neurons
Telomere-to-telomere DNA replication timing profiling using single-molecule sequencing with Nanotiming
Abstract Current temporal studies of DNA replication are either low-resolution or require complex cell synchronisation and/or sorting procedures. Here we introdu...
Integrating genetic subtypes with PET scan monitoring to predict outcome in diffuse large B-cell lymphoma
Multi-modal conditional diffusion model using signed distance functions for metal-organic frameworks generation
Pt/IrOx enables selective electrochemical C-H chlorination at high current
Single-cell data reveal heterogeneity of investment in ribosomes across a bacterial population
Generalized cue reactivity in rat dopamine neurons after opioids
AbstractCue reactivity is the maladaptive neurobiological and behavioral response upon exposure to drug cues and is a major driver of relapse. A widely accepted assumption is that drugs of abuse resul...
The global RNA-binding protein RbpB is a regulator of polysaccharide utilization in Bacteroides thetaiotaomicron
AbstractParamount to human health, symbiotic bacteria in the gastrointestinal tract rely on the breakdown of complex polysaccharides to thrive in this sugar-deprived environment. Gut Bacteroides are m...
Hypoxia-tolerant polymeric photosensitizer prodrug for cancer photo-immunotherapy
Intratumor heterogeneity of EGFR expression mediates targeted therapy resistance and formation of drug tolerant microenvironment
AbstractEpidermal growth factor receptor (EGFR) tyrosine kinase inhibitors are commonly used to treat non-small cell lung cancers with EGFR mutations, but drug resistance often emerges. Intratumor het...
Deciphering the effect of UM171 on human hematopoietic progenitor cell fate through clonal analysis
Dynamics of specialization in neural modules under resource constraints
AbstractThe brain is structurally and functionally modular, although recent evidence has raised questions about the extent of both types of modularity. Using a simple, toy artificial neural network se...