Nature Communications
Articles in this Issue
G-quadruplex stabilization provokes DNA breaks in human PKD1, revealing a second hit mechanism for ADPKD
AbstractThe “secondhit” pathway is responsible for biallelic inactivation of many tumor suppressors, where a pathogenic germline allele is joined by somatic mutation of the remaining functional allele...
The transcriptional repressor HEY2 regulates mitochondrial oxidative respiration to maintain cardiac homeostasis
Limitation of switching sensory information flow in flexible perceptual decision making
Engineering ultra-strong electron-phonon coupling and nonclassical electron transport in crystalline gold with nanoscale interfaces
AbstractElectrical resistivity in good metals, particularly noble metals such as gold (Au), silver (Ag), or copper, increases linearly with temperature (T) for T > ΘD, where ΘD is the Debye tempera...
Modulation of glymphatic system by visual circuit activation alleviates memory impairment and apathy in a mouse model of Alzheimer’s disease
2.5-dimensional covalent organic frameworks
AbstractCovalently bonded crystalline substances with micropores have broad applications. Covalent organic frameworks (COFs) are representative of such substances. They have so far been classified int...
Polyolefin reweaved ultra-micropore membrane for CO2 capture
Experimental identification of topological defects in 2D colloidal glass
AbstractTopological defects are singularities within a field that cannot be removed by continuous transformations. The definition of these irregularities requires an ordered reference configuration, c...
Changing patterns of global nitrogen deposition driven by socio-economic development
Topolectrical space-time circuits
Rational engineering of minimally immunogenic nucleases for gene therapy
AbstractGenome editing using CRISPR-Cas systems is a promising avenue for the treatment of genetic diseases. However, cellular and humoral immunogenicity of genome editing tools, which originate from...
Artificial molecular communication network based on DNA nanostructures recognition
Revealing the excited-state mechanisms of the polymorphs of a hot exciton material
A stable and biocompatible shortwave infrared nanoribbon for dual-channel in vivo imaging
Monogamy relations for relativistically causal correlations
AbstractNon-signalling conditions encode minimal requirements that any (quantum) systems must satisfy in order to be consistent with special relativity. Recent works have argued that in scenarios invo...
Tracking the correlation between spintronic structure and oxygen evolution reaction mechanism of cobalt-ruthenium-based electrocatalyst
Author Correction: PatCID: an open-access dataset of chemical structures in patent documents
Towards non-blinking and photostable perovskite quantum dots
Magnetochiral charge pumping due to charge trapping and skin effect in chirality-induced spin selectivity
Molecular properties of the RmlT wall teichoic acid rhamnosyltransferase that modulates virulence in Listeria monocytogenes
Machine learning derived retinal pigment score from ophthalmic imaging shows ethnicity is not biology
AbstractFew metrics exist to describe phenotypic diversity within ophthalmic imaging datasets, with researchers often using ethnicity as a surrogate marker for biological variability. We derived a con...
MCM2-7 ring closure involves the Mcm5 C-terminus and triggers Mcm4 ATP hydrolysis
AbstractThe eukaryotic helicase MCM2-7, is loaded by ORC, Cdc6 and Cdt1 as a double-hexamer onto replication origins. The insertion of DNA into the helicase leads to partial MCM2-7 ring closure, while...
ATLAS-seq: a microfluidic single-cell TCR screen for antigen-reactive TCRs
E4F1 coordinates pyruvate metabolism and the activity of the elongator complex to ensure translation fidelity during brain development
AbstractPyruvate metabolism defects lead to severe neuropathies such as the Leigh syndrome (LS) but the molecular mechanisms underlying neuronal cell death remain poorly understood. Here, we unravel a...