Design and application of synthetic 17B-HSD13 substrates reveals preserved catalytic activity of protective human variants

M Michelle R. Garnsey Y Yang Wang D David J. Edmonds M Matthew F. Sammons B Benjamin Reidich Y Youngwook Ahn Y Yotam Ashkenazi A Anthony Carlo M Matthew A. Cerny K Karen J. Coffman J Jeffrey A. Culver A Anne-Marie Dechert Schmitt H Heather Eng E Ethan L. Fisher J Jemy A. Gutierrez L Larry James S Samantha Jordan J Jeffrey T. Kohrt (Pfizer Medicine Design) M Melissa Kramer E Erik A. LaChapelle J Jack C. Lee J Jisun Lee D Dongmei Li Z Zhenhong Li S Shenping Liu J Jianhua Liu T Thomas V. Magee M Melissa R. Miller M Michael Moran D Deane M. Nason N Nicole L. Nedoma S Steven V. O’Neil M Mary A. Piotrowski J Jillian Racich R Ruth F. Sommese L Lucy M. Stevens A Ann S. Wright J Jun Xiao L Liying Zhang (Ministry of Education Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Department of Chemistry) D Dahui Zhou O Ornella Barrandon M Michelle F. Clasquin