Nature Communications
Articles in this Issue
ACSS2 drives senescence-associated secretory phenotype by limiting purine biosynthesis through PAICS acetylation
GWAS meta-analysis of psoriasis identifies new susceptibility alleles impacting disease mechanisms and therapeutic targets
Abstract Psoriasis is a common, debilitating immune-mediated skin disease. Genetic studies have identified biological mechanisms of psoriasis risk, including tho...
Unraveling the molecular basis of substrate specificity and halogen activation in vanadium-dependent haloperoxidases
Abstract Vanadium-dependent haloperoxidases (VHPOs) are biotechnologically valuable and operationally versatile biocatalysts. VHPOs share remarkable active-site structural similarities yet d...
Nuclear retention of unspliced HIV-1 RNA as a reversible post-transcriptional block in latency
Abstract HIV-1 latency is mainly characterized at transcriptional level, and little is known about post-transcriptional mechanisms and their contribution to reactivation. The viral protein R...
Structural basis of error-prone DNA synthesis by DNA polymerase θ
Author Correction: BWC0977, a broad-spectrum antibacterial clinical candidate to treat multidrug resistant infections
Regulating cellular metabolism and morphology to achieve high-yield synthesis of hyaluronan with controllable molecular weights
CatPred: a comprehensive framework for deep learning in vitro enzyme kinetic parameters
Addendum: High economic costs of reduced carbon sinks and declining biome stability in Central American forests
Realization of a one-dimensional topological insulator in ultrathin germanene nanoribbons
Pupil size reveals arousal level fluctuations in human sleep
Abstract Recent animal research has revealed the intricate dynamics of arousal levels that are important for maintaining proper sleep resilience and memory consolidation. In humans,...
Pan-cancer multi-omic model of LINE-1 activity reveals locus heterogeneity of retrotransposition efficiency
Abstract Somatic mobilization of LINE-1 (L1) has been implicated in cancer etiology. We analyzed a recent TCGA data release comprised of nearly 5000 pan-cancer paired tumor-normal whole-geno...
NIR-triggering cobalt single-atom enzyme switches off-to-on for boosting the interactive dynamic effects of multimodal phototherapy
Observation of metal-organic interphase in Cu-based electrochemical CO2-to-ethanol conversion
Ligand efficacy shifts a nuclear receptor conformational ensemble between transcriptionally active and repressive states
Abstract Nuclear receptors (NRs) are thought to dynamically alternate between transcriptionally active and repressive conformations, which are stabilized upon ligand binding. Most NR...
Highly oxidized products from the atmospheric reaction of hydroxyl radicals with isoprene
Abstract Isoprene (C5H8) globally accounts for half of the non-methane hydrocarbon flux into Earth´s atmosphere. Its degradation is mainly initiated by the gas-phase reaction with OH radical...
Translational error in mice increases with ageing in an organ-dependent manner
Cryo-EM structure of the β-1,3-glucan synthase FKS1-Rho1 complex
Direct observation of ultrafast symmetry reduction during internal conversion of 2-thiouracil using Coulomb explosion imaging
Abstract The photochemistry of heterocyclic molecules plays a decisive role for processes and applications like DNA photo-protection from UV damage and organic photocatalysis. The photochemi...
Rare genetic associations with human lifespan in UK Biobank are enriched for oncogenic genes
Abstract Human lifespan is shaped by genetic and environmental factors. To enable precision health, understanding how genetic variants influence mortality is ess...
Organic photovoltaic mini-module providing more than 5000 V for energy autonomy of dielectric elastomer actuators
Abstract Dielectric elastomer actuators (DEAs) are widely used for soft robotics. The required voltages of over 1000 V are usually supplied by amplifiers with batteries or power grids which...
Advanced multi-modal mass spectrometry imaging reveals functional differences of placental villous compartments at microscale resolution
Abstract The placenta is a complex and heterogeneous organ that links the mother and fetus, playing a crucial role in nourishing and protecting the fetus throughout pregnancy. Integrative sp...
HBV-associated hepatocellular carcinomas inhibit antitumor CD8+ T cell via the long noncoding RNA HDAC2-AS2
Scalable preparation of perovskite films with homogeneous structure via immobilizing strategy for high-performance solar modules
Bone morphogenetic protein (BMP) signaling determines neuroblastoma cell fate and sensitivity to retinoic acid
Abstract Retinoic acid (RA) is a standard-of-care neuroblastoma drug thought to be effective by inducing differentiation. Curiously, RA has little effect on primary human tumors duri...