Nature Communications

Swapping rice for alternative cereals can reduce climate-induced production losses and increase farmer incomes in India

Screening the human druggable genome identifies ABHD17B as an anti-fibrotic target in hepatic stellate cells

Multimodal histopathologic models stratify hormone receptor-positive early breast cancer

Molecular glues of the regulatory ChREBP/14-3-3 complex protect beta cells from glucolipotoxicity

HCN4 channels sense temperature and determine heart rate responses to heat

Genomically defined hypervirulent Klebsiella pneumoniae contributed to early-onset increased mortality

Two-photon absorption under few-photon irradiation for optical nanoprinting

Abstract Two-photon absorption (TPA) has been widely applied for three-dimensional imaging and nanoprinting; however, the efficiency of TPA imaging and nanoprinting using laser scann...

Strong charge-photon coupling in planar germanium enabled by granular aluminium superinductors

Abstract High kinetic inductance superconductors are gaining increasing interest for the realisation of qubits, amplifiers and detectors. Moreover, thanks to their high impedance, quantum bu...

Integrated device of luminescent solar concentrators and electrochromic supercapacitors for self-powered smart window and display

Pretrained transformers applied to clinical studies improve predictions of treatment efficacy and associated biomarkers

Abstract Cancer treatment has made significant advancements in recent decades, however many patients still experience treatment failure or resistance. Attempts to identify determinan...

Marine sulphate captures a Paleozoic transition to a modern terrestrial weathering environment

FLT1 and other candidate fetal haemoglobin modifying loci in sickle cell disease in African ancestries

Associations of prenatal metal exposure with child neurodevelopment and mediation by perturbation of metabolic pathways

Inverse melting and re-entrant transformations of the vortex lattice in amorphous Re6Zr thin film

In situ valence-transited arsenic nanosheets for multi-modal therapy of colorectal cancer

Dissecting tumor cell programs through group biology estimation in clinical single-cell transcriptomics

Visible-light-driven CO2 photoreduction over atomically strained indium sites in ambient air

Superstoichiometric reversible and manipulable copper-ion intercalation in niobium selenide

Next-generation water-saving strategies for greenhouses using a nexus approach with modern technologies

General lightweight framework for vision foundation model supporting multi-task and multi-center medical image analysis

Abstract The foundation model, trained on extensive and diverse datasets, has shown strong performance across numerous downstream tasks. Nevertheless, its application in the medical domain i...

Harnessing engineered symbionts to combat concurrent malaria and arboviruses transmission

Chenodeoxycholic acid modulates cholestatic niche through FXR/Myc/P-selectin axis in liver endothelial cells

Dissecting apicoplast functions through continuous cultivation of Toxoplasma gondii devoid of the organelle

Abstract The apicoplast, a relic plastid organelle derived from secondary endosymbiosis, is crucial for many medically relevant Apicomplexa. While it no longer performs photosynthesis, the o...

Systematic biotechnological production of isoprenoid analogs with bespoke carbon skeletons

Structure-based discovery of hydrocarbon-stapled paxillin peptides that block FAK scaffolding in cancer

Abstract The focal adhesion kinase (FAK) scaffold provides FAK-targeted cancer therapeutics with greater efficacy and specificity than traditional kinase inhibitors. The FAK scaffold functio...