Nature Communications
Articles in this Issue
Molecular basis for the calcium-dependent activation of the ribonuclease EndoU
A genotype-first approach identifies high incidence of NF1 pathogenic variants with distinct disease associations
Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis
Targeting CCNE1 amplified ovarian and endometrial cancers by combined inhibition of PKMYT1 and ATR
Abstract Ovarian cancers (OVCAs) and endometrial cancers (EMCAs) with CCNE1- amplification are often resistant to standar...
A clinically accessible small multimodal radiology model and evaluation metric for chest X-ray findings
A robust and omnidirectional-sensitive electronic antenna for tactile-induced perception
790,000 years of millennial-scale Cape Horn Current variability and interhemispheric linkages
Abstract Millennial-scale variations in the strength and position of the Antarctic Circumpolar Current exert considerable influence on the global meridional overturning circulation and the o...
Dynamic coding and sequential integration of multiple reward attributes by primate amygdala neurons
Abstract The value of visual stimuli guides learning, decision-making, and motivation. Although stimulus values often depend on multiple attributes, how neurons extract and integrate...
AI-based detection and classification of anomalous aortic origin of coronary arteries using coronary CT angiography images
Abstract Anomalous aortic origin of the coronary artery (AAOCA) is a rare cardiac condition that can lead to ischemia or sudden cardiac death, yet it is often overlooked or falsely classifie...
Th1 polarization in Bordetella pertussis vaccine responses is maintained through a positive feedback loop
Endosomal chloride/proton exchangers need inhibitory TMEM9 β-subunits for regulation and prevention of disease-causing overactivity
Abstract The function of endosomes critically depends on their ion homeostasis. A crucial role of luminal Cl−, in addition to that of H+, is increasingly recognized. Both ions are transporte...
Severe inflammation and lineage skewing are associated with poor engraftment of engineered hematopoietic stem cells in patients with sickle cell disease
Abstract In sickle cell disease (SCD), the β6Glu→Val substitution in the β-globin leads to red blood cell sickling. The transplantation of autologous, genetically modified hematopoietic stem...
Exercise-induced anti-obesity effects in male mice generated by a FOXO1-KLF10 reinforcing loop promoting adipose lipolysis
Perfect anomalous refraction metasurfaces empowered half-space optical beam scanning
Author Correction: A combined adjuvant and ferritin nanocage based mucosal vaccine against Streptococcus pneumoniae induces protective immune responses in a murine model
Analysis of allohexaploid wheatgrass genome reveals its Y haplome origin in Triticeae and high-altitude adaptation
Complete biosynthetic pathway of furochromones in Saposhnikovia divaricata and its evolutionary mechanism in Apiaceae plants
Kupffer cell and recruited macrophage heterogeneity orchestrate granuloma maturation and hepatic immunity in visceral leishmaniasis
Abstract In murine models of visceral leishmaniasis (VL), the parasitization of resident Kupffer cells (resKCs) drives early Leishmania infan...
Structure and inhibition mechanisms of Mycobacterium tuberculosis essential transporter efflux protein A
Abstract A broad chemical genetic screen in Mycobacterium tuberculosis (Mtb) identified compounds (BRD-8000.3 and BRD-9327) that inhibit the essential efflux pump EfpA. To understand the mec...
The future of antibiotic use in livestock
Abstract Governments worldwide have pledged to reduce antimicrobial use in the agri-food system. This study projects global livestock antibiotic use quantities through 2040 under various sce...
Mineralogical controls on PFAS and anthropogenic anions in subsurface soils and aquifers
Abstract Per- and polyfluoroalkyl substances (PFAS) migrate into the environment through various means, e.g., soil-amendment impurities and ambient atmospheric deposition, potentially result...