Nature Communications
Articles in this Issue
Photoluminescent delocalized excitons in donor polymers facilitate efficient charge generation for high-performance organic photovoltaics
A noncanonical role of SAT1 enables anchorage independence and peritoneal metastasis in ovarian cancer
CodonTransformer: a multispecies codon optimizer using context-aware neural networks
Abstract Degeneracy in the genetic code allows many possible DNA sequences to encode the same protein. Optimizing codon usage within a sequence to meet organism-specific preferences...
Genetically regulated eRNA expression predicts chromatin contact frequency and reveals genetic mechanisms at GWAS loci
Abstract The biological functions of extragenic enhancer RNAs and their impact on disease risk remain relatively underexplored. In this work, we develop in silico models of genetically regul...
Pathogen infection induces sickness behaviors through neuromodulators linked to stress and satiety in C. elegans
Abstract When animals are infected by a pathogen, peripheral sensors of infection signal to the brain to induce adaptive behavioral changes known as sickness behaviors. While the pathways th...
Separate brainstem circuits for fast steering and slow exploratory turns
Abstract Locomotion requires precise tuning of descending commands to scale turning movements, such as rapid steering during prey pursuit or shallow turns during exploration. We show that th...
Lineage-specific microbial protein prediction enables large-scale exploration of protein ecology within the human gut
Abstract Microbes use a range of genetic codes and gene structures, yet these are often ignored during metagenomic analysis. This causes spurious protein predictions, preventing func...
Photon-efficient camera with in-sensor computing
Giant energy density nitride dielectrics enabled by a paraelectric-metaparaelectric phase transition
Ultrahigh-power-density flexible piezoelectric energy harvester based on freestanding ferroelectric oxide thin films
Integrated proteogenomic characterization of localized prostate cancer identifies biological insights and subtype-specific therapeutic strategies
Abstract Localized prostate cancer (PCa) is highly variable in their response to therapies. Although a fraction of this heterogeneity can be explained by clinical factors or genomic and tran...
Nitrous oxide activates layer 5 prefrontal neurons via SK2 channel inhibition for antidepressant effect
Abstract Nitrous oxide (N2O) induces rapid and durable antidepressant effects. The cellular and circuit mechanisms mediating this process are not known. Here we find that a single dose of in...
Robust super-structured porous hydrogel enables bioadaptive repair of dynamic soft tissue
Muscle fiber Myc is dispensable for muscle growth and its forced expression severely perturbs homeostasis
Abstract The oncogenic transcription factor Myc stimulates many growth processes including cell cycle progression and ribosome biogenesis. Myc expression is low in adult skeletal muscle, but...
Epigenetic mechanisms controlling human leukemia stem cells and therapy resistance
Editorial Expression of Concern: Ballistic superconductivity in semiconductor nanowires
Younger Dryas drought and IPO climate modulation during the Antarctic Cold Reversal in New Zealand
Comparative single-nucleus RNA-seq analysis revealed localized and cell type-specific pathways governing root-microbiome interactions
Abstract Roots can recognize and differentially respond to beneficial and pathogenic microbes, which are fundamental for maintaining root microbiome homeostasis, plasticity, and plant fitnes...
Emergence of an oceanic CO2 uptake hole under global warming
Cholangiocarcinoma PDHA1 succinylation suppresses macrophage antigen presentation via alpha-ketoglutaric acid accumulation
Author Correction: “Pink power”—the importance of coralline algal beds in the oceanic carbon cycle
Author Correction: Marine biogenic humic substances control iron biogeochemistry across the Southern Ocean
Intrapleural pressure-controlled piezo-catalytic nanozyme for the inhibition of malignant pleural effusion
Sulphostin-inspired N-phosphonopiperidones as selective covalent DPP8 and DPP9 inhibitors
Abstract Covalent chemical probes and drugs combine unique pharmacologic properties with the availability of straightforward compound profiling technologies via chemoproteomic platforms. The...
A novel PLpro inhibitor improves outcomes in a pre-clinical model of long COVID
Abstract The COVID-19 pandemic caused by the coronavirus SARS-CoV-2 has highlighted the vulnerability of a globally connected population to zoonotic viruses. The FDA-approved coronavirus ant...