Nature Communications

Molecular basis of SLC19A1-mediated folate and cyclic dinucleotide transport

Photocatalytic deoxygenative Z-selective olefination of aliphatic alcohols

Stabilization mechanism accommodating genome length variation in evolutionarily related viral capsids

Anionic high-entropy doping engineering for electromagnetic wave absorption

Cross-ancestry genome-wide association study identifies implications of SORL1 in cerebral beta-amyloid deposition

Distinct ventral tegmental area neuronal ensembles are indispensable for reward-driven approach and stress-driven avoidance behaviors

Abstract Assigning valence to stimuli for adaptive behavior is an essential function, involving the ventral tegmental area (VTA). VTA cell types are often defined through neurotransm...

Neoadjuvant Aumolertinib for unresectable stage III EGFR-mutant non-small cell lung cancer: a single-arm phase II trial

Machine learning in point-of-care testing: innovations, challenges, and opportunities

Molecular insights into the α6β4 nicotinic acetylcholine receptor function and ligand recognition

Hydration-induced stiffness enabling robust thermal cycling of high temperature fuel cells cathode

Radiative pumping vs vibrational relaxation of molecular polaritons: a bosonic mapping approach

Abstract We present a formalism to study molecular polaritons based on the bosonization of molecular vibronic states. This formalism accommodates an arbitrary number of molecules N, excitati...

Structural mimicry of UM171 and neomorphic cancer mutants co-opts E3 ligase KBTBD4 for HDAC1/2 recruitment

Abstract Neomorphic mutations and drugs can elicit unanticipated effects that require mechanistic understanding to inform clinical practice. Recurrent indel mutations in the Kelch do...

A unique mechanism of snRNP core assembly

Anomalous transient enhancement of planetary ion escape at Mars

A deep learning framework for instrument-to-instrument translation of solar observation data

Bilateral in-situ functionalization towards Ah-scale aqueous zinc metal batteries

Effective extracellular payload release and immunomodulatory interactions govern the therapeutic effect of trastuzumab deruxtecan (T-DXd)

Inhibition of tau neuronal internalization using anti-tau single domain antibodies

Abstract In Alzheimer’s disease, tau pathology spreads across brain regions as the disease progresses. Intracellular tau can be released and taken up by nearby neurons. We evaluated single d...

Shigella effector IpaH1.4 subverts host E3 ligase RNF213 to evade antibacterial immunity

The greater role of Southern Ocean warming compared to Arctic Ocean warming in shifting future tropical rainfall patterns

Altermagnetic ground state in distorted Kagome metal CsCr3Sb5

Metavalent alloying and vacancy engineering enable state-of-the-art cubic GeSe thermoelectrics

Accurate eye tracking from dense 3D surface reconstructions using single-shot deflectometry

Intranasal influenza virus-vectored vaccine offers protection against clade 2.3.4.4b H5N1 infection in small animal models

Photoredox cobalt-catalyzed asymmetric desymmetric reductive coupling of cyclobutenes with alkynes